Global stakeholders have raised concerns about the implications of COVID-19 for violence against children (VAC). An increased risk of violence could result from a variety of compounding structural, interpersonal and individual-level risk factors, including the increased economic strain placed on families, stay-at-home orders, school closures and other COVID-19 response measures. Over 165 governments have urged the UN to “Protect our Children” and the leaders of 22 organizations have called for the need to integrate measures to protect children from violence in COVID-19 response plans. To guide action on preventing and responding to violence, eight UN agencies outlined a child rights and multi-sectoral framework agenda for action. Initial and preliminary evidence on COVID-19 and VAC suggests that the pandemic could affect not only the risks of violence, but also help-seeking behavior and access to violence-related services.