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Children and COVID-19 Research Library

UNDER DEVELOPMENT UNICEF Innocenti's curated library of COVID-19 + Children research

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Psychological burden of quarantine in children and adolescents: A rapid systematic review and proposed solutions

AUTHOR(S)
Nazish Imran; Irum Aamer; Muhammad Imran Sharif; et al.

Published: July 2020   Pakistan Journal of Medical Sciences
As COVID-19 grips the world, many people are quarantined or isolated resulting in adverse consequences for the mental health of youth. This rapid review takes into account the impact of quarantine on mental health of children and adolescents, and proposes measures to improve psychological outcomes of isolation. Three electronic databases including PubMed, Scopus, and ISI Web of Science were searched. Two independent reviewers performed title and abstract screening followed by full-text screening. This review article included 10 studies. The seven studies before onset of COVID 19 about psychological impact of quarantine in children have reported isolation, social exclusion stigma and fear among the children. The most common diagnoses were acute stress disorder, adjustment disorder, grief, and post-traumatic stress disorder. Three studies during the COVID-19 pandemic reported restlessness, irritability, anxiety, clinginess and inattention with increased screen time in children during quarantine. These adverse consequences can be tackled through carefully formulated multilevel interventions.
Cite this research | Open access | Vol.: 35 | Issue: 5 | No. of pages: 10 | Language: English | Tags: child mental health, children, mental health, psychological distress, COVID-19 response, COVID-19 | Topics: Mental Health, Child Protection
Coronavirus disease 2019 (COVID-19) in children and/or adolescents: a meta-analysis

AUTHOR(S)
Alessandro Mantovani; Elisabetta Rinaldi; Chiara Zusi; et al.

Published: June 2020   Nature Paediatric Research
This review systematically researched in PubMed, Scopus and Web of Science databases observational studies describing COVID-19 in children and/or adolescents until April 11, 2020. Data regarding clinical and radiological features were extracted from eligible studies and meta-analysis was performed using random-effects modeling. The study finds that children and/or adolescents tend to have a mild COVID-19 course with a good prognosis.
Compared to adults, children and/or adolescents tend to have a mild COVID-19 course with a good prognosis.
Rapid Systematic Review: The Impact of Social Isolation and Loneliness on the Mental Health of Children and Adolescents in the Context of COVID-19

AUTHOR(S)
Maria Elizabeth Loades DClinPsy; Eleanor Chatburn; Nina Higson-Sweeney

Published: June 2020   Journal of the American Academy of Child & Adolescent Psychiatry
The COVID-19 pandemic has resulted in governments implementing disease containment measures such as school closures, social distancing and home quarantine. Children and adolescents are experiencing a prolonged state of physical isolation from their peers, teachers, extended family and community networks. Quarantine in adults generally has negative psychological effects including confusion, anger, and post-traumatic distress. Duration of quarantine, infection fears, boredom, frustration, lack of necessary supplies, lack of information, financial loss, and stigma appear to increase the risk of negative psychological outcomes. Social distancing and school closures may, therefore, increase mental health problems in children and adolescents, already at higher risk of developing mental health problems compared to adults  at a time when they are also experiencing anxiety over a health threat and threats to family employment/income.
Impact of COVID-19 on children: special focus on the psychosocial aspect

AUTHOR(S)
Ritwik GHOSH Ghosh; Mahua J. Dubey; Subhankar Chatterje; et al.

Published: June 2020   Minerva Pediatrica
Although medical literature shows that children are minimally susceptible to 2019-Corona virus disease (COVID-19), they are hit the hardest by psychosocial impact of this pandemic. Being quarantined in homes and institutions may impose greater psychological burden than the physical sufferings caused by the virus. School closure, lack of outdoor activity, aberrant dietary and sleeping habits are likely to disrupt children’s usual lifestyle and can potentially promote monoto- ny, distress, impatience, annoyance and varied neuropsychiatric manifestations. Incidences of domestic violence, child abuse, adulterated online contents are on the rise. Children of single parent and frontline workers suffer unique problems. The children from marginalized communities are particularly susceptible to the infection and may suffer from extended ill-consequences of this pandemic, such as child labor, child trafficking, child marriage, sexual exploitation and death etc. Parents, pediatricians, psychologists, social workers, hospital authorities, government and non-governmental organizations have important roles to play to mitigate the psychosocial ill-effects of COVID-19 on children and adolescents. To provide the basic amenities, social security, medical care, and to minimize the educational inequities among the children of the different strata of the society are foremost priorities.
Cite this research | Open access | Vol.: 72 | Issue: 3 | No. of pages: 12 | Language: English | Tags: child psychology, psychology, pandemic, COVID-19 response, COVID-19, impact | Topics: Mental Health, Health
Coronavirus disease 2019 (COVID-19) in children: a systematic review of imaging findings

AUTHOR(S)
Susan C. Shelmerdine; Jovan Lovrenski; Pablo Caro-Domínguez; et al.

Published: June 2020   Pediatric radiology
COVID-19 is a novel coronavirus infection that can cause a severe respiratory illness and has been declared a pandemic by the World Health Organization (WHO). Because children appear to be less severely affected than adults, their imaging appearances have not been extensively reported.
COVID-19 in Children: An Ample Review

AUTHOR(S)
Ioana M Ciuca

Published: June 2020   Risk management and healthcare policy
The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. An extensive literature search was performed to identify papers on COVID-19 (SARS-CoV-2 infection) in children, published between January 1, 2020 and April 1, 2020. There were 44 relevant papers on COVID-19 in children. The results showed that COVID-19 occurs in 0.39–12.3% of children. Clinical signs and symptoms are comparable to those in adults, but milder forms and a large percentage of asymptomatic carriers are found among children. Elevated inflammatory markers are associated with complications and linked to various co-infections. Chest computed tomography (CT) scans in children revealed structural changes similar to those found in adults, with consolidations surrounded by halos being somewhat specific for children with COVID-19. The recommended treatment includes providing symptomatic therapy, with no specific drug recommendations for children. The prognosis is much better for children compared to adults. This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. The prognosis is much better for children compared to adults, but with the progression of the pandemic; the cases in children might change in the future.
Pediatric COVID-19: Systematic review of the literature

AUTHOR(S)
Patel Neha

Published: May 2020   American Journal of Otolaryngology
A systematic review of the literature was performed to gain insight into pediatric COVID-19 epidemiology. Specifically, Pubmed and Google Scholar databases were searched to identify any relevant article with a focus on Pediatric Covid 19, Pediatric Covid-19, Pediatric SARS-COV-2, and Pediatric Coronavirus 19. Results show that, in contrast to adults, most infected children appear to have a milder course and have better outcomes overall. Additional care may be needed for children with comorbidities and younger children. This review also suggests that unilateral CT chest imaging findings were seen in 36.4% pediatric COVID-19 patients. This is particularly concerning as the work-up of pediatric patients with cough may warrant a bronchoscopy to evaluate for airway foreign bodies. Extra precautions need to be taken with personal protective equipment for these cases, as aerosolizing procedures may be a method of viral transmission.
Cite this research | Open access | Vol.: 41 | Issue: 5 | Language: English | Tags: child health, respiratory diseases, COVID-19, epidemiology, multi-country | Topics: Health
Potential effectiveness and safety of antiviral agents in children with coronavirus disease 2019: a rapid review and meta-analysis

AUTHOR(S)
Qianling Shi; Qi Zhou; Xia Wang; et al.

Published: May 2020   Annals of Transnational Medicine
A novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected on December 8, 2019, when several cases of pneumonia of unknown etiology were reported in China (1-3). As of April 12, a total of 1,696,588 confirmed cases had been reported in more than 200 countries, and the number of cases was still rapidly increasing, creating global alarm and concerns about the impact on health care and economy of the affected areas. As the COVID-19 outbreak presents a new, life-threatening disease. Our aim was to assess the potential effectiveness and safety of antiviral agents for COVID-19 in children.
Cite this research | Open access | Vol.: 8 | Issue: 10 | No. of pages: 16 | Language: English | Tags: children, pandemic, COVID-19 response, COVID-19 | Topics: Health, Child Protection
Efficacy and safety of antibiotic agents in children with COVID-19: a rapid review

AUTHOR(S)
Jianjian Wang; Yuyi Tang; Yanfang Ma; et al.

Published: May 2020   ANNALS of TRANSNATIONAL MEDICINE
In December 2019, an unexplained pneumonia emerged in Wuhan, China, and has since then spread rapidly throughout the country and the world. On February 11, the International Committee on Taxonomy of Viruses (ICTV) named the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On the same day, the World Health Organization (WHO) named the disease caused by the virus as COVID-19. According to the latest data, by March 31, 2020, a total of 1,174,866 cases had been confirmed worldwide, with 36,405 deaths. The number of confirmed cases in children continues to increase, with the youngest infected person being diagnosed only several minutes after birth. The outbreak of COVID-19 is the third introduction of a highly pathogenic coronavirus into the human population in the twenty-first century, after the severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS) epidemics. The aim of this review was to evaluate the efficacy and safety of antibiotic agents in children with COVID-19, as well as to introduce the present situation of antibiotics use and bacterial coinfections in COVID-19 patients
Cite this research | Open access | Vol.: 8 | Issue: 10 | No. of pages: 12 | Language: English | Tags: children, pandemic, COVID-19 response, COVID-19, impact | Topics: Health
Systematic Review of COVID‐19 in Children Shows Milder Cases and a Better Prognosis Than Adults

AUTHOR(S)
Jonas F. Ludvigsson

Published: March 2020   Acta Paediatrica

The coronavirus disease 2019 (COVID‐19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare. A systematic literature review was carried out to identify papers on COVID‐19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), using the MEDLINE and Embase databases between January 1 and March 18, 2020.

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UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents. Learn more.

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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.