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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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Long-term effect of COVID-19 on lung imaging and function, cardiorespiratory symptoms, fatigue, exercise capacity, and functional capacity in children and adolescents: a systematic review and meta-analysis

Catherine Campos; Samantha Prokopich; Hal Loewen (et al.)

Published: December 2022   Journal: Healthcare
The long-term sequela of COVID-19 on young people is still unknown. This systematic review explored the effect of COVID-19 on lung imaging and function, cardiorespiratory symptoms, fatigue, exercise capacity and functional capacity in children and adolescents ≥ 3 months after infection. A systemic search was completed in the electronic databases of PubMed, Web of Science and Ovid MEDLINE on 27 May 2022. Data on the proportion of participants who had long-term effects were collected, and one-group meta-analysis were used to estimate the pooled prevalence of the outcomes studied.
Cite this research | Open access | Vol.: 10 | Issue: 12 | No. of pages: 11 | Language: English | Topics: Health | Tags: child health, COVID-19, health services, Heart diseases, respiratory diseases
Experiences of siblings of children with congenital heart disease during Coronavirus disease 2019; a qualitative interview study

Elizabeth Bichard; Stephen McKeever; Suzanne Bench (et al.)

Published: January 2022   Journal: Journal of Pediatric Nursing

This study aimed to explore siblings' perceptions of having a brother or sister with congenital heart disease in the UK during the COVID-19 pandemic. Siblings of children with congenital heart disease aged 8–17 years old were interviewed via video call technology between September 2020 and February 2021.  A reflexive thematic analysis of these interviews to generate themes was conducted.

Activity during the COVID-19 pandemic in children with cardiac rhythm management devices

Robert Przybylski; Molly Craig; Matthew Lippmann (et al.)

Published: December 2021   Journal: Pediatric Cardiology
Decreased physical activity is associated with cardiovascular, metabolic and mental health disease. While decreases in physical activity during the COVID-19 pandemic have been described in the general population, there is a paucity of data regarding children with underlying cardiovascular disease. This study hypothesized there would be a decrease in physical activity at the onset of the COVID-19 pandemic. Performed a single-center, retrospective cohort study of children aged < 19 years with cardiac rhythm management devices. Patients were included if they had device-measured physical activity data from > 80% of dates from February 3, 2020 through June 30, 2020. Patients with significant neurologic/neuromuscular disease were excluded.
Predictive value of cardiac markers in the prognosis of COVID-19 in children

Ufuk Utku Güllü; Şükrü Güngör; Sevcan İpek

Published: July 2021   Journal: The American Journal of Emergency Medicine
Occasionally, children with COVID-19 may develop arrhythmia, myocarditis, and cardiogenic shock involving multisystemic inflammatory syndrome in children (MIS-C). This study aimed to identify the laboratory parameters that may predict early cardiovascular involvement in these patients.
Cite this research | Open access | Vol.: 43 | No. of pages: 307-311 | Language: English | Topics: Health | Tags: child health, COVID-19, Heart diseases, infectious disease
Impact of COVID-19 on pediatric clinical research

Nhu N. Tran; Michelle Tran; Jeraldine Lopez (et al.)

Published: June 2021   Journal: Journal of Pediatric Nursing
Many public institutions and settings have taken action to limit exposure to and slow the spread of the novel coronavirus (COVID-19). This paper sought to characterize the impact of stay-at-home orders on the study of cerebral autoregulation and its association with developmental delays in infants with congenital heart disease compared with healthy controls.
COVID-19 disease during pregnancy and peripartum period: a cardiovascular review

Sedighe Hantoushzadeh; Seyedeh Maedeh Nabavian; Zahra Soleimani (et al.)

Published: May 2021   Journal: Current Problems in Cardiology
Pregnancy with various physiological effects on cardiovascular system, makes mothers with borderline cardiovascular reserve at significant risk for adverse events during labor and early postpartum period. Cardiac imaging modalities, have shown that COVID-19 disease is associated with subclinical myocardial injury in significant numbers of infected people, even in mild or asymptomatic disease and previous healthy ones. Herein, this study have discussed the cardiovascular aspects of prepartum pregnant women with COVID-19 disease, especially patients with moderate to severe illness. Also, it has proposed how to handle the hemodynamic load during labor and the first 48 hours postpartum in the hypoxemic overloaded parturients with possible subclinical myocardial injury.
Responding to non-communicable diseases during and beyond the COVID-19 pandemic

This brief provides guidance for governments, policymakers, UN agencies and development partners to address non-communicable diseases (NCDs) as an integral part of the COVID-19 response and in broader efforts for achieving the 2030 Agenda for Sustainable Development. NCDs, such as cardiovascular disease, cancer, diabetes and chronic respiratory disease, are amplifying the impacts of COVID-19, and COVID-19 is exacerbating the burden of NCDs, particularly in already disadvantaged communities. Almost one fourth (22%) of the global population is estimated to have an underlying condition that increases their vulnerability to COVID-19, and most of these conditions are NCDs. Urgent action across sectors is needed to address the root causes of NCDs and increase access to affordable and quality treatments and prevention.

Children’s heart and COVID-19: up-to-date evidence in the form of a systematic review

Giulia Sanna; Pier Paolo Bassareo

Published: May 2020   Journal: European Journal of Pediatrics

The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and potentially life-threatening arrhythmias are the main aftermaths. A few studies showed that myocardial injury in adult patients is often linked with a fatal outcome. Conversely, scientific evidence in children is sparse, although several reports were published with the description of a cardiac involvement in COVID-19 paediatric patients. In these young subjects, a background of surgically treated congenital heart disease seems to be a predisposing factor. This systematic review is aimed at summarizing all COVID-19 cases with a cardiac involvement published in paediatric age and trying to explain the underlying mechanisms responsible for COVID-19-related myocardial damage.

Cite this research | Open access | Vol.: 179 | No. of pages: 1079-1087 | Language: English | Tags: child diseases, child health, COVID-19, Heart diseases
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UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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Check our quarterly thematic digests on children and COVID-19

Each quarterly thematic digest features the latest evidence drawn from the Children and COVID-19 Research Library on a particular topic of interest.
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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.