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Children and COVID-19 Research Library

UNDER DEVELOPMENT UNICEF Innocenti's curated library of COVID-19 + Children research

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1 - 15 of 31
An autopsy study of the spectrum of severe COVID-19 in children: From SARS to different phenotypes of MIS-C

AUTHOR(S)
Amaro Nunes Duarte-Neto; Elia Garcia Caldini; Michele Soares Gomes-Gouvea (et al.)

Published: May 2021   Journal: EClinicalMedicine
COVID-19 in children is usually mild or asymptomatic, but severe and fatal paediatric cases have been described. The pathology of COVID-19 in children is not known; the proposed pathogenesis for severe cases includes immune-mediated mechanisms or the direct effect of SARS-CoV-2 on tissues. We describe the autopsy findings in five cases of paediatric COVID-19 and provide mechanistic insight into the mechanisms involved in the pathogenesis of the disease. Children and adolescents who died with COVID-19 between March 18 and August 15, 2020 were autopsied with a minimally invasive method. Tissue samples from all vital organs were analysed by histology, electron microscopy (EM), reverse-transcription polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC).
A case series of children and young people admitted to a tertiary care hospital in Germany with COVID-19

AUTHOR(S)
Jonathan Remppis; Tina Ganzenmueller; Malte Kohns Vasconcelos (et al.)

Published: February 2021   Journal: BMC Infectious Diseases
While our knowledge about COVID-19 in adults has rapidly increased, data on the course of disease and outcome in children with different comorbidities is still limited. Prospective, observational study at a tertiary care children’s hospital in southern Germany. Clinical and virology data from all paediatric patients admitted with SARS-CoV-2 infection at our hospital were prospectively assessed.
Cite this research | Open access | No. of pages: 6 | Language: English | Topics: Health | Tags: child diseases, child health, COVID-19 response, hospitalization, lockdown | Countries: Germany
Serious infectious events and ibuprofen administration in pediatrics: a narrative review in the era of COVID-19 pandemic

AUTHOR(S)
Lucia Quaglietta; Massimo Martinelli; Annamaria Staiano

Published: January 2021   Journal: Italian Journal of Pediatrics
Despite its recognized efficacy and tolerability profile, during the last decade a rise of adverse events following ibuprofen administration in children has been reported, including a possible role in worsening the clinical course of infections. Our aim was to critically evaluate the safety of ibuprofen during the course of pediatric infectious disease in order to promote its appropriate use in children.
PTSD in parents of children with severe diseases: a systematic review to face Covid-19 impact

AUTHOR(S)
Martina Corsi; Alessandro Orsini; Virginia Pedrinelli (et al.)

Published: January 2021   Journal: Italian Journal of Pediatrics
The literature agrees on the impact of post-traumatic stress symptoms in parents of seriously ill children but there is less clarity about the real extent and gender differences of this psychopathological risk. The recent Covid-19 outbreak highlighted new burdens for researchers on Post Traumatic Stress Disorder (PTSD) and clear evidence-based knowledge on this issue is timely needed. This review aims to present a synthesis of the updated evidence on PTSD rates in parents of children with severe diseases. It also aims to try to understand if research in this field has been refined over time with the long-term intent to better face the new challenges of Covid-19 in the paediatric field.
Pediatric inflammatory bowel disease and the effect of COVID-19 pandemic on treatment adherence and patients’ behavior

AUTHOR(S)
Lev Dorfman; Raouf Nassar; Dalit Binjamin Ohana (et al.)

Published: January 2021   Journal: Pediatric Research
The coronavirus disease (COVID-19) pandemic affects medical care worldwide, including patients with inflammatory bowel disease (IBD). Thus, we aimed to assess its impact on health care provision, fear of infection, adherence to medical treatment, and compliance with preventative instructions in children and adolescents with IBD.
Impact of COVID-19 lockdown in children with neurological disorders in Italy

AUTHOR(S)
Stefania Maria Bova; Martina Basso; Marta Francesca Bianchi (et al.)

Published: December 2020

The costs and benefits of full lockdown measures are debated. Neurologically impaired children are a vulnerable population with specific needs in terms of protection against infection and access to health services. This study investigated the effects of lockdown on the health of children with neurological disorders and on their access to care during lockdown.

Pneumonia & diarrhea progress report 2020
Institution: Save the Children
Published: November 2020

Pneumonia and diarrhea are leading killers of children under the age of five, claiming the lives of more young children globally than any other infectious disease. The impacts of the impacts of the COVID-19 pandemic aggravate these heath risks. International Vaccine Access Center's (IVAC) annual Pneumonia & Diarrhea Progress Report evaluates the progress across 10 high-impact indicators outlined in the Global Action Plan for the Prevention and Control of Pneumonia and Diarrhea (GAPPD) in the 15 countries with the greatest burden of under-five pneumonia and diarrhea deaths.

What chances do children have against COVID-19? Is the answer hidden within the thymus?

AUTHOR(S)
Hatice Güneş; Serpil Dinçer; Can Acıpayam (et al.)

Published: October 2020   Journal: European Journal of Pediatrics
As with other types of coronaviruses, SARS-CoV-2 affects children less frequently, and it has been observed that the disease is mild. In the pathogenesis of a standard viral infection, the pathogen’s contact with the mucosa is initially followed by an innate immunity response. T cells are the primary decisive element in adaptive immunity capability. For this reason, the adaptive immune response mediated by the thymus is a process that regulates the immune response responsible for preventing invasive damage from a virus. Regulatory T cells (T-reg) are active during the early periods of life and have precise roles in immunomodulation. The thymus is highly active in the intrauterine and neonatal period; it begins to shrink after birth and continues its activity until adolescence. The loss of T-reg function by age results in difficulty with the control of the immune response, increased inflammation as shown in coronavirus disease (COVID-19) as an inflammatory storm. Also, the thymus is typically able to replace the T cells destroyed by apoptosis caused by the virus. Thymus and T cells are the key factors of pathogenesis of SARS-CoV-2 in children. Since thymus activity and T lymphocyte function in children protect them against the virus effects, stimulating and preventing the inhibition of the thymus can be possible treatment components against COVID-19.
Comparing Chinese children and adults with RT-PCR positive COVID-19: a systematic review

AUTHOR(S)
Yigang Pei; Wenguang Liu; Ismail Bilal Masokano (et al.)

Published: October 2020   Journal: Journal of Infection and Public Health
The various clinical manifestations of COVID-19 with RT-PCR positive patients have been reported. However, the differences in the clinical presentation between children and adults were unclear. Thus, this review aimes to investigate the differences in the clinical manifestations and imaging characteristics between Chinese children and adults with COVID-19 by systematically analyzing the data derived from some latest literatures. An extensive search of COVID-19 papers was conducted in PubMed and Chinese medical journal network, and relevant articles were selected based on some standard requirements. The included papers were analyzed for differences in clinical manifestation between children and adults with COVID-19 after the quality evaluation with the QUADAS-2 tool.
Cite this research | Open access | Vol.: 13 | Issue: 10 | No. of pages: 1424-1431 | Language: English | Topics: Health | Tags: child diseases, child health, COVID-19 | Countries: China
Duration of respiratory and gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and synthesis of data

AUTHOR(S)
Cecilia L. H. Xu; Manjri Raval; Jesse A. Schnall (et al.)

Published: September 2020   Journal: The Pediatric Infectious Disease Journal
Children with coronavirus disease 2019 (COVID-19) are more likely to have mild or no symptoms compared with adults and may represent important vectors for transmitting the virus. Little is known about the duration of respiratory and gastrointestinal viral shedding in children with COVID-19. This study  performed a systematic search of Ovid MEDLINE, Embase and Cochrane CENTRAL databases for studies reporting real-time reverse transcriptase polymerase chain reaction (rt-PCR) results in children with COVID-19, then extracted and synthesized data on duration of viral shedding from symptom onset in respiratory and gastrointestinal samples.
Cite this research | Open access | Vol.: 39 | Issue: 9 | No. of pages: 249-256 | Language: English | Topics: Health | Tags: child diseases, child health, COVID-19
COVID-19 and child neurology care

AUTHOR(S)
Sheffali Gulati; Juhi Gupta; Priyanka Madaan

Published: September 2020   Journal: Neurology India
The escalating pandemic of coronavirus disease 2019 (COVID-19) has posed a multitude of challenges for pediatric neurologists. These range from managing children with COVID-19 presenting with neurological involvement to diagnosing COVID-19 in children presenting with isolated neurological manifestations and providing a continuum of care to children with pre-existing or newly diagnosed neurological disorders during this difficult time.
Cite this research | Open access | Vol.: 68 | Issue: 4 | No. of pages: 952-954 | Language: English | Topics: Health | Tags: child care services, child diseases, disabled children
Social distancing for COVID-19 and diagnoses of other infectious diseases in children

AUTHOR(S)
Jonathan Hatoun; Emily Trudell Correa; Sara Mary Alice Donahue (et al.)

Published: September 2020   Journal: Pediatrics
Social distancing (SD) during the coronavirus disease 2019 (COVID-19) pandemic has largely removed children from school, day care, and other contact with peers. In addition to reducing transmission of severe acute respiratory syndrome coronavirus 2, these changes would be expected to reduce the transmission of other infectious diseases among children. This study aims to determine the effect of SD on 12 infectious diseases commonly diagnosed in pediatric primary care that are contagious to various extents.
Cite this research | Open access | Vol.: 146 | Issue: 4 | Language: English | Topics: Health | Tags: child diseases, child health, infectious disease | Countries: United States
Definitely mixed feelings: the effect of COVID-19 on bereavement in parents of children who died from cancer

AUTHOR(S)
Gabrielle Helton; Joanne Wolfe; Jennifer M. Snaman

Published: September 2020   Journal: Journal of Pain and Symptom Management
This study aims to examine ways in which COVID-19 has affected the bereavement experiences of parents whose children died of cancer before the pandemic.
Cite this research | Open access | Vol.: 60 | Issue: 5 | No. of pages: 15-20 | Language: English | Tags: child diseases, child health
Children with cancer during COVID-19 pandemic: early experience in Mexico

AUTHOR(S)
Enrique López-Aguilar; Rocío Cárdenas-Navarrete; Alfredo Simental-Toba (et al.)

Published: September 2020   Journal: Pediatric Blood & Cancer
Recommendations were published for the attention and care of children and adolescents with cancer or leukemia during the pandemic,1 and an invitation and call for sharing experiences was requested by Eric Bouffet on March 2020.2 Reports of children with cancer from United States and Italy had informed that most of the affected patients had a mild disease and very few of them required critical care. The aim of this report is to share the experience with cancer patients cared for in a tertiary care level hospital in Mexico City.
Cite this research | Open access | No. of pages: 1 | Language: English | Topics: Health | Tags: child diseases, child health | Countries: Mexico
Decrease of respiratory diseases in one social children welfare institute in Shanxi Province during COVID-19

AUTHOR(S)
B. Liu; Q. F. Han; W. P. Liang

Published: September 2020   Journal: Journal of Public Health
This study surveyed and analyzed common diseases among children under the age of 14 in one social children welfare institute in Shanxi Province from January to May in 2018–2020 by the year-on-year method. In view of the above anti-epidemic measures, it indicates that the children gathering institutions should strengthen effective personal protection and public health management to reduce infectious disease among children.
Cite this research | Open access | No. of pages: 5 | Language: English | Topics: Health | Tags: child diseases, institutionalized children, respiratory diseases | Countries: China
1 - 15 of 31

UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.

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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.