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AUTHOR(S) Judith Ju Ming Wong; Chin Seng Gan; Sanghvi Heli Kaushal (et al.)
There is a scarcity of population-level data of pediatric COVID-19 infection from Southeast Asia. This study aims to describe and compare epidemiological, clinical, laboratory and outcome data among pediatric COVID-19 cases versus controls in two neighboring countries, Singapore and Malaysia. It used a test-negative case–control study design recruiting all suspected COVID-19 cases (defined by either clinical or epidemiological criteria) from January 2020to March 2021 admitted to two main pediatric centers in Singapore and Malaysia. Data were collected using a standardized registry (Pediatric Acute and Critical Care COVID-19 Registry of Asia).
AUTHOR(S) Jacob Szeszulski; Ghadir Helal Salsa; Paula Cuccaro (et al.)
AUTHOR(S) Sarah Ciotti; Shannon A. Moore; Maureen Connolly (et al.)
AUTHOR(S) Deena Elkafrawi; Giovanni Sisti; Felipe Mercado (et al.)
There are limited studies on predisposing factors for COVID-19 positivity in asymptomatic pregnant women. The literature published to date on asymptomatic COVID-19 pregnant carriers does not focus on pregnancy or pre-pregnancy comorbidities. This study wanted to identify risk factors for COVID-19 in asymptomatic pregnant women. It performed a retrospective chart review of 263 asymptomatic pregnant women admitted to labour and delivery at New York City Health + Hospitals/Lincoln. It analysed the association between race, body mass index (BMI), smoking, indication for admission, gravidity, parity, pre-pregnancy comorbidity, pregnancy comorbidity via uni- and multivariate statistical tests. Only Hispanic race was significant in the univariate analysis (p = .049). At the post-hoc analysis, Hispanics had a higher proportion of COVID-19 cases compared to non-Hispanic Blacks (p = .019). No variables were significantly associated with COVID-19 positivity in the multivariate analysis.
AUTHOR(S) Chloe A. Teasdale; Luisa N. Borrell; Yanhan Shen (et al.)
Testing remains critical for identifying pediatric cases of COVID-19 and as a public health intervention to contain infections. This study surveyed US parents to measure the proportion of children tested for COVID-19 since the start of the pandemic, preferred testing venues for children, and acceptability of school-based COVID-19 testing. It conducted an online survey of 2074 US parents of children aged ≤12 years in March 2021. It applied survey weights to generate national estimates, and it used Rao-Scott adjusted Pearson χ2 tests to compare incidence by selected sociodemographic characteristics. It used Poisson regression models with robust SEs to estimate adjusted risk ratios (aRRs) of pediatric testing.
AUTHOR(S) Suzanna Awang Bono; Ching Sin Siau; Won Sun Chen (et al.)
AUTHOR(S) Jenny Bauer; Lena-Emilia Schenker; Jennifer Bellingtier
AUTHOR(S) Russell Viner; Claire Waddington; Oliver Mytton (et al.)
AUTHOR(S) Durray Shahwar A. Khan; La‑Raib Hamid; Anna Ali (et al.)
There is dearth of information on COVID-19’s impact on pregnant women. However, literature reported trends of COVID-19 differ, depending on the presence of clinical features upon presentation. This systematic review aimed to assess differences in risk factors, management, complications, and pregnancy and perinatal outcomes in symptomatic vs. asymptomatic pregnant women with confirmed SARS-CoV-2 infection. A search was run on electronic databases to identify studies reporting COVID-19 in pregnancy. Meta-analysis was performed and odds ratios and mean difference with 95% confidence intervals were calculated using Review Manager 5.4.
AUTHOR(S) S. A. Behnood; R. Shafran; S. D. Bennett (et al.)
AUTHOR(S) Jordana Vaz Hendler; Patricia Miranda do Lago; Gabriel Cardozo Müller (et al.)
AUTHOR(S) Takeshi Yoda; Hironobu Katsuyama
AUTHOR(S) Megan Swanson; Marisa Hast; Eleanor Burnett (et al.)
AUTHOR(S) V. Larcher; A. Caplan; J. Brierley
Safe, effective SARS-CoV-2 treatment has not yet been determined, though some drugs have favourable mortality and morbidity benefits in specific situations. No treatments have been explicitly tested in children, who are, therefore, once again therapeutic orphans. We echo calls to enrol patients, including children, into trials but note children recruited to date have been additions to adult studies. Few were recruited during the initial pandemic despite the emergence of PIMS-TS/MIS-C, which surely demanding paediatric-specific research.
AUTHOR(S) Jorge A. Huete-Pérez; Kacey C. Ernst; Cristiana Cabezas-Robelo (et al.)
This study aimed to capture key epidemiological data on SARS-CoV-2 infection in Nicaraguan children (≤18 years) seeking medical care, between 6 October and 16 November 2020. In this cross-sectional study, 418 children were recruited: 319 with symptoms characteristic of COVID-19 and 99 with no symptoms of illness. Children were tested for SARS-CoV-2 RNA using loop-mediated isothermal amplification. A questionnaire was employed to identify symptoms, risk factors, comorbidities and COVID-19 prevention measures. Research was carried out in four hospitals and two clinics in Managua, Nicaragua, where schools and businesses remained open throughout the COVID-19 pandemic.
UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.
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