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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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1 - 15 of 197
Maternal outcomes and risk factors for COVID-19 severity among pregnant women

AUTHOR(S)
Manon Vouga; Guillaume Favre; Oscar Martinez‑Perez (et al.)

Published: July 2021   Journal: Scientific Reports
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9–9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0–7.0] and diabetes [aOR2.2, 95% CI 1.1–4.5].
Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

AUTHOR(S)
KatyA. M. Gaythorpe; Sangeeta Bhatia; Tara Mangal (et al.)

Published: July 2021   Journal: Scientific Reports
SARS-CoV-2 infections have been reported in all age groups including infants, children, and adolescents. However, the role of children in the COVID-19 pandemic is still uncertain. This systematic review of early studies synthesises evidence on the susceptibility of children to SARS-CoV-2 infection, the severity and clinical outcomes in children with SARS-CoV-2 infection, and the transmissibility of SARS-CoV-2 by children in the initial phases of the COVID-19 pandemic. A systematic literature review was conducted in PubMed. Reviewers extracted data from relevant, peer-reviewed studies published up to July 4th 2020 during the first wave of the SARS-CoV-2 outbreak using a standardised form and assessed quality using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.
Public health preventive measures and child health behaviours during COVID-19: a cohort study

AUTHOR(S)
Xuedi Li; Leigh M. Vanderloo; Jonathon L. Maguire (et al.)

Published: July 2021   Journal: Canadian Journal of Public Health

The primary objective was to determine the association between public health preventive measures and children’s outdoor time, sleep duration, and screen time during COVID-19. A cohort study using repeated measures of exposures and outcomes was conducted in healthy children (0 to 10 years) through The Applied Research Group for Kids (TARGet Kids!) COVID-19 Study of Children and Families in Toronto, Canada, between April 14 and July 15, 2020. Parents were asked to complete questionnaires about adherence to public health measures and children’s health behaviours.

Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: prospective cohort study

AUTHOR(S)
Dongli Song; Mary Prahl; Stephanie L. Gaw (et al.)

Published: July 2021   Journal: BMJ Open

This is a prospective observational study aiming toinvestigate maternal immunoglobulins’ (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterise neonatal antibody response to SARS-CoV-2 infection, and to longitudinally follow actively and passively acquired antibodies in infants. It was performed in the public healthcare system in Santa Clara County (California, USA).

Assessment of SARS-CoV-2 testing in children during a low prevalence period (VIGIL study 1)

AUTHOR(S)
Eleonore Eskander; Camille Jung; Corinne Levy (et al.)

Published: July 2021   Journal: Infectious Diseases Now

SARS-CoV-2 induces a broad spectrum of clinical manifestations, which overlap with other viral infections very common in children. This study aimed to describe the percentage of positive SARS-CoV-2 RT-PCR tests in symptomatic and asymptomatic ambulatory children and to determine the predictive factors for positivity. From June 1 to July 31, 2020,  a cross-sectional prospective, multicenter study (13 hospital emergency units and 59 ambulatory pediatricians) was conducted throughout France. Children under 15 years of age with a prescription of nasopharyngeal SARS-CoV-2 RT-PCR test were enrolled.

Presentation of a participatory approach to develop preventive measures to reduce COVID-19 transmission in child care

AUTHOR(S)
Mathias Diebig; Susan Gritzka; Nico Dragano (et al.)

Published: July 2021   Journal: Journal of Occupational Medicine and Toxicology volume
It can be suspected that work in child care facilities is associated with an elevated exposure risk towards SARS-CoV-2 infections. It is still unclear under which conditions employees in those facilities can safely pursue their work. Preventive workplace-related measures to reduce transmission dynamics in this work environment need to be developed. These measures need to build on a solid scientific foundation and be ready for practical use at the same time. Therefore, the aim of the study is to present a participatory approach to identify, minimize, and eliminate workplace-specific COVID-19 transmission within child care. The approach presented combines quantitative as well as qualitative elements and includes a screening of critical workplace conditions and the development of preventive measures to foster a safe workplace design.
School openings and the COVID-19 outbreak in Italy: a provincial-level analysis using the synthetic control method

AUTHOR(S)
Vincenzo Alfano; Salvatore Ercolano; Lorenzo Cicatiello

Published: July 2021   Journal: Health Policy
Schools have been central in the debate about COVID-19. On the one hand, many have argued that they should be kept open, given their importance to youngsters and the future of the country, and the effort many countries have made in establishing protocols to keep them safe. On the other hand, it has been argued that open schools further the spread of the virus, given that these are places with large-scale interaction between teenagers and adults accompanying their children, as well as a major source of congestion on public transportation. This study aims to identify the effect of school openings on the spread of COVID-19 contagion. Italy offers an interesting quasi-experimental setting in this regard due to the scattered openings that schools have experienced. By means of a quantitative analysis, employing a synthetic control method approach, we find that Bolzano, the first province in Italy to open schools after the summer break, had far more cases than its synthetic counterfactual, built from a donor pool formed from the other Italian provinces. Results confirm the hypothesis that despite the precautions, opening schools causes an increase in the infection rate, and this must be taken into account by policymakers.
Evaluation of changes in pediatric healthcare activity during the Covid-19 state of alarm in the Canary Islands

AUTHOR(S)
Valewska G. Wallis Gómez; María Hernández Apolinario; Pedro Saavedra Santana (et al.)

Published: July 2021   Journal: Public Health in Practice

During the SARS-CoV-2 state of alarm (SoA), a 30–70% reduction was observed in the number of visits to Pediatric Emergency Departments (ED), as well as frequent delay in diagnosis or difficulty accessing healthcare services. This study evaluates modifications observed in pediatric healthcare activity during the SoA. This is a descriptive retrospective observational study of the hospital pediatric activity.

The Covid-19 pandemic teaching modalities in Turkey: an evaluation of school gardens and classes

AUTHOR(S)
Murat Başeğmez; Cevdet Coşkun Aydın

Published: July 2021   Journal: Health Policy and Technology

The main scientific contribution of this study is to design an approach that can regulate school safety and student health in gardens and classes during the pandemic period using GIS. The method of this study is based on the use of school areas and building data, the creation of 4m2 social distance areas for students, and the evaluation of these areas in terms of health measures. To this aim, first, the relevant guidelines issued by the government institutions in Turkey during the COVID-19 process were examined, in relation to how they will reflect on education policies regarding the sanitary safety of schools. This data was obtained from open-source data sets. Then, in the application stage, 20 schools were selected in order to analyse the sustainability of education in the Balgat district. In addition, the sanitary conditions of classrooms and garden areas were evaluated within the framework of educational policies, taking into account the capabilities of geographical information systems (GIS).

Factors associated with preventive behaviors for COVID-19 among adolescents in South Korea

AUTHOR(S)
Sunhee Park; Sumi Oh

Published: July 2021   Journal: Journal of Pediatric Nursing
COVID-19's infection rate among adolescents is increasing; hence, it is important to prevent it as it can spread in the community through transmission in schools. It is crucial to determine the extent to which adolescents follow COVID-19 preventive measures and identify factors relating to such behaviors to implement more effective health education. This study aimed to understand factors related to COVID-19 preventive behaviors using the theory of planned behavior (TPB) and the health belief model (HBM) among adolescents in South Korea.
Children and SARS-CoV-2

AUTHOR(S)
Dusan Bogunovic; Miriam Merad

Published: July 2021   Journal: Cell Host & Microbe
A previously immune-naive world population is experiencing natural infection with SARS-CoV-2. Severe COVID-19 predominantly impacts adults, yet multisystem inflammatory disorder primarily impacts children. Herein, this article discusses known clinical and biological features of SARS-CoV-2 in children and reflects on currently identified immune features and discusses what remains unknown.
Cite this research | Open access | Vol.: 29 | Issue: 7 | No. of pages: 1040-1042 | Language: English | Topics: Health | Tags: child health, COVID-19, disease transmission, infectious disease, medical research, respiratory diseases
Prevalence and determinants of symptomatic COVID-19 infection among children and adolescents in Qatar: a cross sectional analysis of 11445 individuals

AUTHOR(S)
Omran A. H. Musa; Tawanda Chivese; Devendra Bansa (et al.)

Published: July 2021   Journal: Epidemiology and Infection
There is a paucity of evidence about the prevalence and risk factors for symptomatic infection among children. This study aimed to describe the prevalence of symptomatic COVID-19 and its risk factors in children and adolescents aged 0-18 years in Qatar.
Anxious and traumatised: users’ experiences of maternity care in the UK during the COVID-19 pandemic

AUTHOR(S)
Julia Sanders; Rebecca Blaylock

Published: July 2021   Journal: Midwifery
The COVID-19 pandemic saw universal, radical, and ultra-rapid changes to UK National Health Services (NHS) maternity care. At the onset of the pandemic, NHS maternity services were stripped of many of the features which support woman and family centred care. In anticipation of unknown numbers of pregnant women and maternity staff potentially sick with COVID-19, services were pared back to the minimum level considered to be required to keep women and their babies safe. The aim of this survey was to understand the impact of COVID-19 public health messaging and pandemic-related service changes on users of maternity care in the UK during the pandemic.
Should older adult pneumococcal vaccination recommendations change due to decreased vaccination in children during the pandemic? A cost-effectiveness analysis

AUTHOR(S)
Kenneth J. Smith; Angela R. Wateska; Mary Patricia Nowalk (et al.)

Published: July 2021   Journal: Vaccine
The COVID-19 pandemic is causing declines in childhood immunization rates. This study examined potential COVID-19-related changes in pediatric 13-valent pneumococcal conjugate vaccine (PCV13) use, subsequent impact on childhood and adult pneumococcal disease rates, and how those changes might affect the favorability of PCV13 use in non-immunocompromised adults aged ≥65 years.
Cite this research | Open access | Vol.: 39 | Issue: 31 | No. of pages: 4278-4282 | Language: English | Topics: Health | Tags: child health, COVID-19, disease transmission, immunization, infectious disease, vaccination, vaccination policies
ISIDOG consensus guidelines on COVID-19 vaccination for women before, during and after pregnancy

AUTHOR(S)
Gilbert G. G. Donders; Svitrigaile Grinceviciene; Kai Haldre (et al.)

Published: June 2021   Journal: Journal of Clinical Medicine
Sars-CoV-2 infection poses particular problems in pregnancy, as the infection more frequently causes severe complications than in unaffected pregnant women or nonpregnant women with SARS-CoV-2 infection. Now that vaccination is available and rapidly being implemented worldwide, the question arises whether pregnant women should be vaccinated, and if so, whether they should receive priority. Available scientific data and available guidelines about vaccination against SARS-CoV-2 were collected by the Guideline Committee of the International Society of Infectious Diseases in Obstetrics and Gynecology (ISIDOG) and were analyzed, discussed and summarized as guidelines for healthcare workers caring for pregnant women. Concluding statements were graded according to the Oxford evidence-based medicine grading system.
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UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.

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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.