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Children and COVID-19 Research Library

UNDER DEVELOPMENT UNICEF Innocenti's curated library of COVID-19 + Children research

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136 - 150 of 165
The clinical course of SARS-CoV-2 positive neonates

AUTHOR(S)
Giuseppe De Bernardo; Maurizio Giordano; Giada Zollo (et al.)

Published: October 2020   Journal: Journal of Perinatology
The COVID-19 pneumonia was firstly reported in Wuhan, China, in December 2019. The disease had a rapid spread all over the word becoming an international public health emergency. Limited data were available on COVID-19 positive neonates. We reviewed relevant literature to understand the clinical course of disease and transmission routes in affected neonates. The aim of the study was evaluating the clinical course and prognosis of SARS-CoV-2 positive neonates. Based on current literature, the hypothesis of vertical transmission of SARS-CoV-2, though conceivable, remains unproven. A research conducted on PubMed database from December 2019 to April 27, 2020 revealed that were reported 25 neonates affected by SARS-CoV-2. Main symptoms were fever, cough, or shortness of breath but often these neonates did not show other symptoms during length stay in hospital. No deaths occurred.
Cite this research | Open access | Vol.: 40 | No. of pages: 1462-1469 | Language: English | Topics: Health | Tags: child care, child health, COVID-19, disease transmission, infectious disease
Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

AUTHOR(S)
Roberto Raschetti; Alexandre J. Vivanti ; Christelle Vauloup-Fellous (et al.)

Published: October 2020   Journal: Nature Communications
A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. This survey aims to clarify the transmission route, clinical features and outcomes of these infections. It presents a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. This report shows that 70% and 30% of infections are due to environmental and vertical transmission, respectively.
Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children

AUTHOR(S)
Judith R. Glynn; Paul A. H. Moss

Published: October 2020   Journal: Scientific Data

The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis, this study identifies 142 datasets with information on severity of disease by age for 32 different infectious diseases, 19 viral and 13 bacterial. For almost all infections, school-age children have the least severe disease, and severity starts to rise long before old age. Indeed, for many infections even young adults have more severe disease than children, and dengue was the only infection that was most severe in school-age children. Together with data on vaccine response in children and young adults, the findings suggest peak immune function is reached around 5–14 years of age. Relative immune senescence may begin much earlier than assumed, before accelerating in older age groups. This has major implications for understanding resilience to infection, optimal vaccine scheduling, and appropriate health protection policies across the life course.

Age-structured model for COVID-19: Effectiveness of social distancing and contact reduction in Kenya

AUTHOR(S)
Mark Kimathi; Samuel Mwalili; Viona Ojiambo (et al.)

Published: October 2020   Journal: Infectious Disease Modelling
Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2. Kenya reported its first case on March 13, 2020 and by March 16, 2020 she instituted physical distancing strategies to reduce transmission and flatten the epidemic curve. An age-structured compartmental model was developed to assess the impact of the strategies on COVID-19 severity and burden. Contacts between different ages are incorporated via contact matrices. Simulation results show that 45% reduction in contacts for 60-days period resulted to 11.5–13% reduction of infections severity and deaths, while for the 190-days period yielded 18.8–22.7% reduction. The peak of infections in the 60-days mitigation was higher and happened about 2 months after the relaxation of mitigation as compared to that of the 190-days mitigation, which happened a month after mitigations were relaxed. Low numbers of cases in children under 15 years was attributed to high number of asymptomatic cases. High numbers of cases are reported in the 15–29 years and 30–59 years age bands. Two mitigation periods, considered in the study, resulted to reductions in severe and critical cases, attack rates, hospital and ICU bed demands, as well as deaths, with the 190-days period giving higher reductions.
COVID-19 trends among school-aged children — United States, March 1–September 19, 2020

AUTHOR(S)
Rebecca T. Leeb; Sandy Price; Sarah Sliwa (et al.)

Published: October 2020   Journal: Morbidity and Mortality Weekly Report

Children aged <10 years can transmit SARS-CoV-2 in school settings, but less is known about COVID-19 incidence, characteristics, and health outcomes among school-aged children (aged 5–17 years) with COVID-19. Since March, 277,285 COVID-19 cases in children have been reported. COVID-19 incidence among adolescents aged 12–17 years was approximately twice that in children aged 5–11 years. Underlying conditions were more common among school-aged children with severe outcomes related to COVID-19. Weekly incidence, SARS-CoV-2 test volume, and percentage of tests positive among school-aged children varied over time and by region of the United States. It is important for schools and communities to monitor multiple indicators of COVID-19 among school-aged children and layer prevention strategies to reduce COVID-19 disease risk for students, teachers, school staff, and families. These results can provide a baseline for monitoring trends and evaluating mitigation strategies.

Cite this research | Vol.: 69 | No. of pages: 1410-1415 | Language: English | Topics: Health | Tags: child health, COVID-19, disease control, disease transmission, schools | Countries: United States
Coronavirus-2019 disease (COVID-19) in children

AUTHOR(S)
Fahri Ovali

Published: September 2020   Journal: Medeniyet Medical Journal
COVID-19 disease affects all ages, but severe cases of the disease and mortality are very rarely seen among children. In most cases, they acquire the virus from their parents or from an another infected person. The exact reasons why the disease has a milder course in children is unknown but high numbers of Angiotensin Converting Enzyme-2 (ACE2) receptors, underdeveloped immune responses, cross-reaction with other viruses, protective effect of fetal hemoglobin and fewer outdoor activities as well as journeys, and nonexposure to air pollution, and smoking. Although many cases are asymptomatic, they can still shed the virus. Materno-fetal vertical transmission has not been shown so far. In symptomatic cases, clinical findings include fever and respiratory symptoms, followed by diarrhea and vomiting. There are signs indicating a possible association between Kawasaki disease and COVID-19. Clinical findings and diagnostic procedures in newborns, and older children are similar
Adapting HIV services for pregnant and breastfeeding women, infants, children, adolescents and families in resource‐constrained settings during the COVID‐19 pandemic

AUTHOR(S)
Alexandra C. Vrazo; Rachel Golin; Nimasha B. Fernando (et al.)

Published: September 2020   Journal: Journal of the International AIDS Society
Protecting pregnant and breastfeeding women, infants, children and adolescents from acquiring SARS‐CoV‐2 while sustaining essential HIV services is an immense global health challenge. Tailored, family friendly programme adaptations for case‐finding, ART delivery and viral load monitoring for these populations have the potential to limit SARS‐CoV‐2 transmission while ensuring the continuity of life‐saving HIV case identification and treatment efforts.
Considerations for school-related public health measures in the context of COVID-19
Institution: *UNICEF, UNESCO, WHO - World Health Organization
Published: September 2020

This Annex is intended to help policy makers and educators with making decisions on running schools as safely as possible during the COVID-19 pandemic. At the forefront of all considerations and decisions should be the continuity of education for children for their  overall  well-being,  health  and  safety.  Nonetheless,  all  decisions  will  have  implications  for  children,  parents  or  caregivers,  teachers and other staff and more broadly, their communities and societies. This document was developed with input from the Technical Advisory Group (TAG) of Experts on Educational Institutions and COVID-19 and experts from WHO, UNICEF, and UNESCO, who jointly reviewed the latest evidence to develop this interim guidance, which considers equity, resource implications, and feasibility.

Susceptibility to SARS-CoV-2 infection among children and adolescents compared with adults

AUTHOR(S)
Russell M. Viner; Oliver T. Mytton; Chris Bonell (et al.)

Published: September 2020   Journal: JAMA Pediatrics

In this systematic review and meta-analysis including 32 studies, children and adolescents younger than 20 years had 44% lower odds of secondary infection with SARS-CoV-2 compared with adults 20 years and older; this finding was most marked in those younger than 10 to 14 years. Data were insufficient to conclude whether transmission of SARS-CoV-2 by children is lower than by adults. Preliminary evidence suggests that children have a lower susceptibility to SARS-CoV-2 infection compared with adults, but the role that children and adolescents play in transmission of this virus remains unclear.

The wide spectrum of COVID-19 clinical presentation in children

AUTHOR(S)
Nadia Nathan; Blandine Prevost; Chiara Sileo (et al.)

Published: September 2020   Journal: Journal of Clinical Medicine
 Ten months after its appearance in December 2019, SARS-CoV-2 has infected more than 25 million patients worldwide. Because children were first identified as potential spreaders of the virus, schools were closed in several countries. However, it rapidly became evident that the number of hospitalized children infected by SARS-CoV-2 was dramatically lower than that of adults. To date, only hypotheses have been raised to explain this difference, so it is of great importance to describe the presentation of this disease among children. This study describes a wide spectrum of COVID-19 manifestation in children in a dedicated pediatric unit in France.
A citizen science facemask experiment and educational modules to improve coronavirus safety in communities and schools

AUTHOR(S)
Sarah E. Eichler; Austin P. Hopperton; Juan José Alava (et al.)

Published: September 2020   Journal: Frontiers in Medicine
There is need to support facemask citizen science and experiential education among children and families as the globe exits from the current lockdown, and teachers and students desire and seek for safe strategies to return to densely-attended schools. COVID-19 is a pandemic respiratory disease that disseminates as infectious respiratory or saliva droplets are released into the environment as people talk, sneeze, and cough. Currently the most publicized methods to prevent local transmission of COVID-19 and promote “droplet safety” in hospitals and communities include hand washing, social distancing, and stay-at-home strategies. In contrast to established benefits for medical masks in hospitals, the benefits of wearing masks or face covers/coverings (hereafter, “facemask”) in the community have been inconsistently debated by the media, creating confusion, and misinformation. Furthermore, high-profile political leaders in countries heavily affected by the pandemic have given misleading signs regarding containment measures associated with COVID-19 increasingly polarizing local communities around arguments on the value of facemasks in promoting public health, which is critically important to incentivize during the emergence of citizens from their lockdowns and during the phase of reopening local economies.
An analysis of child-care and school outbreak data and evidence-based recommendations for opening schools & keeping them open

AUTHOR(S)
Fiona Russell; Kathryn Snow; Margie Danchin (et al.)

Published: September 2020
This report is an analysis of the global literature and available Early Childhood Education and Care (ECEC) and school outbreak data, 25 January 2020 – 31 August 2020. It aims to explore the role of ECEC and schools in transmission of SARS-CoV-2.
Surveillance of COVID-19 school outbreaks, Germany, March to August 2020

AUTHOR(S)
Eveline Otte im Kampe; Ann-Sophie Lehfeld; Silke Buda (et al.)

Published: September 2020   Journal: Eurosurveillance
Mitigation of the coronavirus disease (COVID-19) pandemic in Germany included school closures in early March 2020. After reopening in April, preventive measures were taken in schools. This paper analyses national surveillance system data on COVID-19 school outbreaks during different time periods. After reopening, smaller outbreaks (average: 2.2/week) occurred despite low incidence in the general population. School closures might have a detrimental effect on children and should be applied only cautiously and in combination with other measures.
Ethics of COVID-19-related school closures

AUTHOR(S)
Michael Silverman; Robert Sibbald; Saverio Stranges

Published: August 2020   Journal: Canadian Journal of Public Health
COVID-19 mitigation strategies have led to widespread school closures around the world. Initially, these were undertaken based on data from influenza outbreaks in which children were highly susceptible and important in community-wide transmission. An argument was made that school closures were necessary to prevent harm to vulnerable adults, especially the elderly. Although data are still accumulating, the recently described complication, pediatric multisystem inflammatory syndrome, is extremely rare and children remain remarkably unaffected by COVID-19. We also do not have evidence that children are epidemiologically important in community-wide viral spread. Previous studies have shown long-term educational, social, and medical harms from school exclusion, with very young children and those from marginalized groups such as immigrants and racialized minorities most affected. The policy and ethical implications of ongoing mandatory school closures, in order to protect others, need urgent reassessment in light of the very limited data of public health benefit.
Parents’ knowledge and attitude towards COVID‐19 in children: a Jordanian study

AUTHOR(S)
Sawsan Abuhammad

Published: August 2020   Journal: The International Journal of Clinical Practice

The coronavirus disease 2019 (COVID-19) has had a rapid global spread.  All individuals of all age groups are at risk of COVID-19. This study aims to describe the knowledge and attitude of Jordanian parents regarding COVID-19 in children, including clinical signs of the disease, modes of transmission and protection measures. A cross-section study among Jordanian parents was conducted. The size of the sample was 810. Information regarding the clinical signs of the disease, modes of transmission, protection measures against COVID-19 and satisfaction with governmental measures was collected.


136 - 150 of 165

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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.