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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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1 - 15 of 88
Comparison of the first and second waves of the COVID-19 pandemic in children and adolescents in a middle-income country: Clinical impact associated with SARS-CoV-2 gamma lineage

Eduardo A. Oliveira; Ana Cristina Simões e Silva; Maria Christina L. Oliveira (et al.)

Published: January 2022   Journal: The Journal of Pediatrics

To evaluate the severity and clinical outcomes of the SARS-CoV-2 gamma variant in children and adolescents hospitalized with COVID-19 in Brazil. In this observational retrospective cohort study, we performed an analysis of all 21,591 hospitalized patients aged < 20 years with confirmed SARS-CoV-2 infection registered in a national database in Brazil. The cohort was divided into two groups according to the predominance of SARS-CoV-2 lineages (WAVE1, n = 11,574 and WAVE2, n = 10,017). The characteristics of interest were age, sex, geographic region, ethnicity, clinical presentation, and comorbidities. The primary outcome was time to death, which was evaluated by competing-risks analysis, using cumulative incidence function. A predictive Fine-Gray competitive risks model was developed based on WAVE1 cohort with temporal validation in WAVE2 cohort.

Levels of uncertainty, fear and satisfaction with health professionals: experiences of parents whose children are hospitalized for COVID-19

Meryem Türkan Isik; Rana Can Özdemır; Elif Karadeniz (et al.)

Published: December 2021   Journal: Psychology, Health & Medicine
This study tried to determine the fear and tolerance of uncertainty levels of the parents of children hospitalized with COVID-19, and their satisfaction with the health care received during this time. Data were collected from 130 literate parents. A significant difference was found between the mean scores on the Intolerance of Uncertainty Scale (IUS-12) and the age of the parents and the presence of COVID-19 in other family members and the IUS-12. Also, a significant correlation was found between parents’ fear of COVID-19 and IUS-12 scores. Parents had good levels of satisfaction with health care received and moderate fear of COVID-19 and intolerance of uncertainty levels. As parents’ fear of COVID-19 increased, intolerance of uncertainty increased. The demographic characteristics, levels of fear of COVID-19, and intolerance of uncertainty did not affect the satisfaction levels.
When a child is hospitalized in a Covid-19 ward: an emotional roller coaster for parents

Michal Shteinbuk; Anat Moskovich; Vardit Shemesh-Mileguir (et al.)

Published: December 2021   Journal: Journal of Pediatric Nursing
This study aims to examine the emotions demonstrated by parents of children hospitalized in a pediatric Covid-19 ward. Although Covid-19 is mostly a mild disease in children, a small proportion develop severe disease requiring prolonged intensive care support. On October 1st, 2020, a unique ward for children with Covid-19 was established in a large hospital in Israel. Interviews were conducted with parents of children who had been hospitalized in a pediatric Covid-19 ward.
The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: a population-based study

Helen E. Groves; Jesse Papenburg; Kayur Mehta (et al.)

Published: December 2021   Journal: The Lancet Regional Health - Americas

The COVID-19 pandemic resulted in unprecedented implementation of wide-ranging public health measures globally. During the pandemic, dramatic decreases in seasonal influenza virus detection have been reported worldwide. Information on the impact on paediatric influenza-related hospitalisations is limited. This study describes influenza-related hospitalisation in children in Canada following the onset of the COVID-19 pandemic. Data on influenza-related hospitalisations, intensive care unit (ICU) admissions and in-hospital deaths in children across Canada were obtained from the Canadian Immunisation Monitoring Program, ACTive (IMPACT). This national active surveillance initiative comprises 90% of all tertiary care paediatric beds in Canada. The study period included eleven influenza seasons, from the 2010/2011 season until the 2020/2021 season inclusive. Time series modelling was used to compare the observed to predicted influenza-related hospitalisations following the COVID-19 pandemic.

Cite this research | Vol.: 7 | No. of pages: 8 | Language: English | Topics: Health | Tags: child health, COVID-19, hospitalization, infectious disease, respiratory diseases | Countries: Canada
SARS-CoV-2 testing, infections, and hospital admissions with COVID-19 in children and young people in Scotland: a birth cohort study

Graziella Favarato; Linda Wijlaars; Tom Clemens (et al.)

Published: November 2021   Journal: The Lancet Journal
A strong association between deprivation and severe COVID-19 outcomes has been reported among adults. This study estimated population-based rates of SARS-CoV-2 testing, laboratory-confirmed infections, and hospital admissions with COVID-19 in children and young people (aged 0–23 years) in Scotland according to sociodemographic risk factors. It used a birth cohort of all children and young people born in Scotland in 1997–2020, consisting of linked vital registration, maternity, hospital admissions, and SARS-CoV-2 PCR testing data. Participants were followed from birth or Jan 1, 2020 (whichever occurred last) until Dec 31, 2020, death, or emigration. Admissions with COVID-19 were defined as participants with a positive SARS-CoV-2 test during or up to 28 days before admission to hospital, or a relevant International Classification of Diseases version 10 code recorded (U07.1/U07.2).
Cite this research | Open access | Vol.: 398 | Issue: Special issue S45 | No. of pages: 1 | Language: English | Topics: Health | Tags: adolescent health, child health, COVID-19, health services, hospitalization, infectious disease, pandemic, respiratory diseases | Countries: United Kingdom
Risk of COVID-19 hospital admission among children aged 5–17 years with asthma in Scotland: a national incident cohort study

Ting Shi; Jiafeng Pan; Srinivasa Vittal Katikireddi (et al.)

Published: November 2021   Journal: The Lancet Respiratory Medicine

There is an urgent need to inform policy deliberations about whether children with asthma should be vaccinated against SARS-CoV-2 and, if so, which subset of children with asthma should be prioritised. The authors were asked by the UK's Joint Commission on Vaccination and Immunisation to undertake an urgent analysis to identify which children with asthma were at increased risk of serious COVID-19 outcomes. This national incident cohort study was done in all children in Scotland aged 5–17 years who were included in the linked dataset of Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II).

Asthma as a risk factor for hospitalization in children with COVID-19: a nested case-control study

Kristina Gaietto; Megan Culler Freeman; Leigh Anne DiCicco (et al.)

Published: November 2021   Journal: Pediatric Allergy and Immunology

Most pediatric studies of asthma and COVID-19 to date have been ecological, which offer limited insight. This study evaluated the association between asthma and COVID-19 at an individual level. Using data from prospective clinical registries, it conducted a nested case-control study comparing three groups: children with COVID-19 and underlying asthma (“A+C” cases); children with COVID-19 without underlying disease (“C+” controls); and children with asthma without COVID-19 (“A+” controls).

Epidemiology, clinical features, and outcomes of coronavirus disease among children in Al-Madinah, Saudi Arabia: a retrospective study
Published: November 2021   Journal: International Journal of Pediatrics and Adolescent Medicine

Coronavirus disease (COVID-19) is milder with favorable outcomes in children than in adults. However, detailed data regarding COVID-19 in children from Saudi Arabia are scarce. This study aimed to describe COVID-19 among children in Al-Madinah, Saudi This retrospective observational study included children <14 years old hospitalized with COVID-19 between May 1, 2020 and July 31, 2020. Clinical data, COVID-19 disease severity, and outcomes were collected. The total number of presenting symptoms and signs were computed by counting those recorded upon presentation. The Kruskal-Wallis non-parametric test was used to compare the number of symptoms and signs across all levels of COVID-19 severity.

Risk factors for severe COVID-19 infection in Brazilian children

Jordana Vaz Hendler; Patricia Miranda do Lago; Gabriel Cardozo Müller (et al.)

Published: November 2021   Journal: The Brazilian Journal of Infectious Diseases
The aim of this study was to describe the epidemiological characteristics and clinical outcome of children hospitalized with COVID-19 and identify the risk factors for severe disease. All hospital admissions of pediatric patients between March and December 2020 in the southern region of Brazil were reviewed and the patients positive for RT-PCR for SARS-CoV-2 were identified. This region encompasses a population of over 2.8 million children and adolescents. Data were extracted from a national database that includes all cases of severe acute respiratory syndrome requiring hospitalization in Brazil.
Three months follow-up of children infected with COVID-19

O. Turunc; A. N. Emecen; S. Keskin (et al.)

Published: October 2021   Journal: European Journal of Public Health

There is limited research on children infected with Covid-19 after initial diagnosis. The aim of this study was to describe changes in symptoms in children infected by Covid-19 after 1st and 3rd months of diagnosis. Covid-19 patients age under 18 admitted to the Dokuz Eylul University Hospital, Izmir, Turkey during December 2020 (n = 144) and completed three months follow-up (n = 123) were included in this prospective cohort study. Data on age, sex, parents' educational status, perceived economic status, presence of Covid-19 patient at household, chronic diseases history, initial and existing symptoms and perception of recovery were collected via telephone interviews. Persistent symptom was defined as any symptom reported within a week of the interview. Chi-square and Mann-Whitney U Test were used for univariate analyses.

Cite this research | Open access | Vol.: 31 | Issue: Supplement 3 | No. of pages: 1 | Language: English | Topics: Health | Tags: child health, COVID-19, disease transmission, hospitalization, infectious disease, respiratory diseases | Countries: Turkey
The impact of COVID-19 pandemic on access to treatment for children with cancer in India and treating center practices

Jyotsna Sharma; Amita Mahajan; Sameer Bakhshi (et al.)

Published: October 2021   Journal: Cancer

The coronavirus disease 2019 (COVID-19) pandemic led the Indian government to announce a nationwide lockdown on March 23, 2020. This study aimed to explore the impact of the pandemic on the accessibility of care for children with cancer and to view strategies adopted by hospitals for service delivery. Weekly average of childhood cancer (≤18 years) patient registrations during pre-lockdown period (January 1 to March 23, 2020) were compared with post-lockdown period (March 24 to May 31, 2020). The effect on the scheduled treatment was investigated for post-lockdown period. A survey of health care providers was conducted to determine centers' adopted strategies.

Parent perceptions of pediatric oncology care during the COVID-19 pandemic: an Australian study

Maria C. McCarthy; Jessica Beamish; Catherine M. Bauld (et al.)

Published: October 2021   Journal: Pediatric Blood & Cancer

This study examined parents’ perceptions of their child's oncology care during a period of significant COVID-19 restrictions in Australia. Parents of children, 0–18 years, receiving hospital-based cancer treatment, completed a survey examining their COVID-19 exposure and impact, information and knowledge, and perception of their child's medical care. Recruitment occurred between October and November 2020.

Impact of the COVID-19 pandemic on developmental care practices for infants born preterm

Melissa Scala; Virginia A. Marchman; Edith Brignoni-Pérez (et al.)

Published: October 2021   Journal: Early Human Development

This study aims to o assess the impact of the COVID-19 pandemic on rates of hospital visitation and rates and durations of developmental care practices for infants born preterm. It analyzed electronic medical record data from 129 infants born at less than 32 weeks gestational age (GA) cared for in the Lucile Packard Children's Hospital neonatal intensive care unit (NICU) in a COVID-19-affected period (March 8, 2020 to Nov 30, 2020, n = 67) and the analogous period in 2019 (n = 62). Rates of family visitation and of family- and clinical staff-delivered developmental care were compared across cohorts, adjusting for covariates.

Prevalence and risk factors for SARS-CoV-2 infection in children with and without symptoms seeking care in Managua, Nicaragua: results of a cross-sectional survey

Jorge A. Huete-Pérez; Kacey C. Ernst; Cristiana Cabezas-Robelo (et al.)

Published: September 2021   Journal: BMJ Open

This study aimed to capture key epidemiological data on SARS-CoV-2 infection in Nicaraguan children (≤18 years) seeking medical care, between 6 October and 16 November 2020. In this cross-sectional study, 418 children were recruited: 319 with symptoms characteristic of COVID-19 and 99 with no symptoms of illness. Children were tested for SARS-CoV-2 RNA using loop-mediated isothermal amplification. A questionnaire was employed to identify symptoms, risk factors, comorbidities and COVID-19 prevention measures. Research was carried out in four hospitals and two clinics in Managua, Nicaragua, where schools and businesses remained open throughout the COVID-19 pandemic.

Cite this research | Open access | Vol.: 11 | Issue: 9 | No. of pages: 11 | Language: English | Topics: Health | Tags: child health, COVID-19, disease control, disease transmission, hospitalization, infectious disease | Countries: Nicaragua
Covid-19 infection in pregnant women in Dubai: a case-control study
Published: September 2021   Journal: BMC Pregnancy and Childbirth

Whilst the impact of Covid-19 infection in pregnant women has been examined, there is a scarcity of data on pregnant women in the Middle East. Thus, the aim of this study was to examine the impact of Covid-19 infection on pregnant women in the United Arab Emirates population. A case-control study was carried out to compare the clinical course and outcome of pregnancy in 79 pregnant women with Covid-19 and 85 non-pregnant women with Covid-19 admitted to Latifa Hospital in Dubai between March and June 2020.

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UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.