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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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16 - 30 of 121
A study to assess the risk factors contributing to psychological stress, anxiety and depression in mothers of Covid-19 positive hospitalized children in a tertiary care hospital

AUTHOR(S)
Nitu Malik; Abhishek Dutta; Satyabrata Roy Chowdhary (et al.)

Published: April 2022   Journal: Journal of Paediatrics and Nursing Science
Parents of the COVID -19 positive hospitalized children are facing different psychological stresses which are affecting child’s care and well-being.
This study aims to determine the psychological stress, anxiety and depression and to identify the associated influencing factors in mothers of hospitalized COVID-19 infected children. In this cross-sectional observational study, 150 mothers of COVID-19 positive hospitalized children in a paediatric tertiary care hospital were randomly selected and studied. Data collection tool was a two part questionnaire; the first part was based on ‘Perceived stress scale-10’ and ‘Hospital anxiety and depression scale’ and the second part included stressors related to COVID-19 pandemic selected based on previous researches. The incidence of these stressors and their significance in causing stress, anxiety and depression was assessed using standard statistical methods.
Caregivers' attitudes toward COVID-19 vaccination in children and adolescents with a history of SARS-CoV-2 infection

AUTHOR(S)
Danilo Buonsenso; Piero Valentini; Marina Macchi (et al.)

Published: April 2022   Journal: Frontiers in Pediatrics

Limited data are available on the attitudes of caregivers toward COVID-19 vaccination in children and adolescents with a history of SARS-CoV-2 infection or Long Covid symptoms. The aim of this study was to investigate the vaccine hesitancy among caregivers of children and adolescents with a documented history of SARS-CoV-2 infection and to explore the possible associations between COVID-19 manifestations and the acceptance of the vaccine. Caregivers of children or adolescents with a microbiologically confirmed diagnosis of SARS-CoV-2 infection evaluated in two University Hospitals were interviewed.

Factors associated with hospitalization or intensive care admission in children with COVID-19 in Latin America

AUTHOR(S)
Eduardo López-Medina; German Camacho-Moreno; Martin E. Brizuela (et al.)

Published: April 2022   Journal: Frontiers in Pediatrics

Limited data is available from low-middle and upper-middle income countries of the factors associated with hospitalization or admission to pediatric intensive care unit (PICU) for children with COVID-19. This study aims to describe the factors associated with hospitalization or PICU admission of children with COVID-19 in Latin America. Multicenter, analytical, retrospective study of children reported from 10 different Latin American countries to the Latin-American Society of Pediatric Infectious Diseases (SLIPE-COVID) research network from June 1, 2020, and February 28, 2021. Outpatient or hospitalized children <18 years of age with COVID-19 confirmed by polymerase chain reaction or antigen detection from the nasopharynx were included. Children with multisystem inflammatory syndrome in children (MIS-C) were excluded. Associations were assessed using univariate and multivariable logistic regression models.

Effect of the COVID-19 outbreak on the incidence of other respiratory and gastrointestinal infections in children in Thai Binh, Vietnam in 2020

AUTHOR(S)
Quoc Tien Nguyen; Thi Loi Dao; Thi Dung Pham (et al.)

Published: April 2022   Journal: Journal of Epidemiology and Global Health

This study aims to evaluate the impact of COVID-19 mitigation measures on the total number of consultations for respiratory and gastrointestinal infections among children under 16 years in Thai Binh Pediatric Hospital, Vietnam during the year 2020. A retrospective study was carried out to review consecutive consultations occurring in children admitted from January 01, 2016 to December 31, 2020. All medical records were collected from the central numeric database of the hospital. Diagnoses were documented according to the International Classification of Diseases 10 criteria.

Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease

AUTHOR(S)
Setareh Mamishi; Babak Pourakbari; Mehrzad Mehdizadeh (et al.)

Published: April 2022   Journal: BMC Infectious Diseases

The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (COVID-19) is still rising. The aim of this study was to describe the epidemiological, clinical, laboratory, and imaging features of hospitalized patients with COVID-19 at an Iranian referral pediatrics hospital and to compare these parameters between hospitalized patients with and without severe disease, multisystem inflammatory syndrome in children (MIS-C) and children with acute COVID-19, as well as deceased and discharged cases. This study included hospitalized children and adolescents (≤ 18 years) with suspected COVID-19 who had positive results for SARS-CoV-2.

Trends in pediatric hospitalizations and mortality during the Covid-19 pandemic in an urban setting in Cameroon

AUTHOR(S)
Andreas Chiabi; Mfie Nji Forgwei; Marie Bissong (et al.)

Published: April 2022   Journal: Journal of Tropical Pediatrics

The first case of coronavirus disease 2019 (COVID-19) in Cameroon was recorded in March 2020. In response to the pandemic, most countries like Cameroon instituted a number of control measures to curb its spread accross the country. These COVID-19 control measures added to the fear of this disease within the population may have led to other detrimental health effects like: the pattern of hospitalizations and hospital outcomes. This is a cross-sectional study with data from in-patient admission records of children admitted to the pediatric ward of the Regional Hospital Bamenda over a 24 months period (1st of March 2019 to the 28th of February 2021). The pre-pandemic period in Cameroon (that is, the first 12 months, from March 2019 to February 2020) and the pandemic period (that is, the last 12 months, from March 2020 to February 2021) were compared.

Cite this research | Open access | Vol.: 68 | Issue: 3 | No. of pages: 8 | Language: English | Topics: Health | Tags: child health, child mortality, COVID-19, hospitalization, infectious disease, pandemic, urban areas | Countries: Cameroon
Risk factors for COVID-19-related mortality in hospitalized children and adolescents with diabetes mellitus: an observational retrospective cohort study

AUTHOR(S)
Eduardo A. Oliveira; Robert H. Mak; Enrico A. Colosimo (et al.)

Published: March 2022   Journal: Pediatric Diabetes

Diabetes has been recognized as a major comorbidity for COVID-19 severity in adults. This study aimed to characterize the clinical outcomes and risk factors for COVID-19-related death in a large cohort of hospitalized pediatric patients with diabetes. It performed an analysis of all pediatric patients with diabetes and COVID-19 registered in SIVEP-Gripe, a Brazilian nationwide surveillance database, between February 2020 and May 2021. The primary outcome was time to death, which was evaluated considering discharge as a competitive risk by using cumulative incidence function.

Cite this research | Open access | Vol.: 23 | Issue: 3 | No. of pages: 10 | Language: English | Topics: Health | Tags: adolescent health, child health, COVID-19, diabetes, hospitalization, infectious disease, mortality rate, pandemic | Countries: Brazil
Risk factors for SARS-CoV-2 infection and hospitalisation in children and adolescents in Norway: a nationwide population-based study

AUTHOR(S)
Ketil Størdal; Paz Lopez-Doriga Ruiz; Margrethe Greve-Isdahl (et al.)

Published: March 2022   Journal: BMJ Open

This study aims to determine risk factors for SARS-CoV-2 infection and hospitalisation among children and adolescents. It is a nationwide, population-based cohort study which was conducted in Norway from 1 March 2020 to 30 November 2021 and included all Norwegian residents<18 years of age.

Cite this research | Open access | Vol.: 12 | Issue: 3 | No. of pages: 8 | Language: English | Topics: Health | Tags: adolescent health, child health, COVID-19, disease transmission, hospitalization, infectious disease, pandemic, risk | Countries: Norway
Incidence of child abuse with subdural hemorrhage during the first year of the COVID-19 pandemic: a nationwide study in France

AUTHOR(S)
Fiorella Caron; Pierre Tourneux; Hyppolite Tchidjou Kuekou (et al.)

Published: March 2022   Journal: European Journal of Pediatrics
The global COVID-19 pandemic prompted governments to impose unprecedented sanitary measures, such as social distancing, curfews, and lockdowns. In France and other countries, the first COVID-19 lockdown raised concerns about an increased risk of child abuse. Abusive head trauma (AHT) is one of the most serious forms of child abuse in children aged 0–24 months and constitutes the leading cause of death in children under 2 years of age. Subdural hemorrhage (SDH) is present in 89% of cases of AHT and constitutes one of the most specific, objective clinical presentations in the diagnosis of child abuse. This French nationwide study sought to evaluate the potential impact of the first year of the COVID-19 pandemic on the incidence of hospital admissions for child abuse with SDH, relative to the two previous years. This study conducted a nationwide, retrospective study of data in the French national hospital discharge summary database by applying the International Classification of Diseases (10th Revision) codes for SDH and for child abuse.
Spectrum of COVID-19 disease in children: a retrospective analysis comparing wave 1 and wave 2 from a tertiary hospital in South India

AUTHOR(S)
T. P. Murugan; Ghosh Urmi; Julia Rajan Roshni (et al.)

Published: March 2022   Journal: Indian Journal of Pediatrics

The electronic medical records of children younger than 16 y of age with laboratory-confirmed COVID-19 infection between June 1st 2020 and May 31st 2021 at Christian Medical College, Vellore were retrospectively reviewed. Demographic, clinical, and laboratory data were collected on a predesigned case record form and analyzed. A total of 988 children were diagnosed with confirmed COVID-19 during the study period. Of these, there were 585 children diagnosed during the 1st wave (June 2020–Feb 2021) and 403 children during the 2nd wave (March 2021–May 2021).

Behavioral problems of pediatric patients recovered from COVID-19 in Wuhan, China

AUTHOR(S)
Han Xiao; Qi Liu; Hong Mei (et al.)

Published: March 2022   Journal: Acta Psychologica
Coronavirus disease 2019 (COVID-19) is profoundly affecting lives around the globe. Previous studies on COVID-19 mainly focused on epidemiological, clinical, and radiological features of patients with confirmed infection. Little attention has been paid to the follow-up of recovered patients. As a vulnerable population to adverse events, the health status of the COVID-19 recovered pediatric patients is of great concern. This study aimed to investigate the prevalence of behavioral problems among pediatric patients recovered from the COVID-19 in Wuhan, China.
Infants hospitalized for acute COVID-19: disease severity in a multicenter cohort study

AUTHOR(S)
Joanna Merckx; Shaun K. Morris; Joan Robinson (et al.)

Published: February 2022   Journal: European Journal of Pediatrics
Age is the most important determinant of COVID-19 severity. Infectious disease severity by age is typically J-shaped, with infants and the elderly carrying a high burden of disease. This study reports on the comparative disease severity between infants and older children in a multicenter retrospective cohort study of children 0 to 17 years old admitted for acute COVID-19 from February 2020 through May 2021 in 17 pediatric hospitals. It compares clinical and laboratory characteristics and estimate the association between age group and disease severity using ordinal logistic regression.
Sanitary measures to contain COVID-19 spread decreased pediatric hospitalizations due to other respiratory infections in São Paulo, Brazil

AUTHOR(S)
Gabriela Marengone Altizani; Viviane da Mata Pasti Balbão; Gilberto Gambero Gaspar (et al.)

Published: February 2022   Journal: Jornal de Pediatria

After the Covid-19 pandemics hit Brazil and sanitary measures were adopted to contain its dissemination, pediatric hospital admissions were apparently fewer than usual. The authors aimed to describe the time trends of public hospital admissions of children and adolescents due to respiratory infections (RIs) in São Paulo State, Brazil, before and after the adoption of sanitary measures to contain the dissemination of Covid-19. Ecological, time-series study on the monthly average number of admissions per day of children and adolescents (< 16 years) admitted to public hospitals of São Paulo due to acute RIs between January 2008 and March 2021. Data from 2008 to 2019 were used to adjust the statistical model, while data from 2020 and 2021 were compared to the values predicted by the model.

Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study

AUTHOR(S)
Jeané Cloete; Annelet Kruger; Maureen Masha (et al.)

Published: February 2022   Journal: The Lancet Child & Adolescent Health

South Africa reported a notable increase in COVID-19 cases from mid-November, 2021, onwards, starting in Tshwane District, which coincided with the rapid community spread of the SARS-CoV-2 omicron (B.1.1.529) variant. This increased infection rate coincided with a rapid increase in paediatric COVID-19-associated admissions to hospital (hereafter referred to as hospitalisations). The Tshwane Maternal-Child COVID-19 study is a multicentre observational study which investigated the clinical manifestations and outcomes of paediatric patients (aged ≤19 years) who had tested positive for SARS-CoV-2 and were admitted to hospital for any reason in Tshwane District during a 6-week period at the beginning of the fourth wave of the COVID-19 epidemic in South Africa. It used five data sources, which were: (1) COVID-19 line lists; (2) collated SARS-CoV-2 testing data; (3) SARS-CoV-2 genomic sequencing data; (4) COVID-19 hospitalisation surveillance; and (5) clinical data of public sector COVID-19-associated hospitalisations among children aged 13 years and younger.

Which children and young people are at higher risk of severe disease and death after hospitalisation with SARS-CoV-2 infection in children and young people: a systematic review and individual patient meta-analysis

AUTHOR(S)
Rachel Harwood; Helen Yan; Nishanthi Talawila Da Camara (et al.)

Published: February 2022   Journal: EClinicalMedicine
This study aimed to describe pre-existing factors associated with severe disease, primarily admission to critical care, and death secondary to SARS-CoV-2 infection in hospitalised children and young people (CYP), within a systematic review and individual patient meta-analysis. It searched Pubmed, European PMC, Medline and Embase for case series and cohort studies published between 1st January 2020 and 21st May 2021 which included all CYP admitted to hospital with ≥ 30 CYP with SARS-CoV-2 or ≥ 5 CYP with PIMS-TS or MIS-C. Eligible studies contained (1) details of age, sex, ethnicity or co-morbidities, and (2) an outcome which included admission to critical care, mechanical invasive ventilation, cardiovascular support, or death. Studies reporting outcomes in more restricted groupings of co-morbidities were eligible for narrative review. It used random effects meta-analyses for aggregate study-level data and multilevel mixed effect models for IPD data to examine risk factors (age, sex, comorbidities) associated with admission to critical care and death. Data shown are odds ratios and 95% confidence intervals (CI).
16 - 30 of 121

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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.