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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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151 - 165 of 342
Immunologic response, efficacy, and safety of vaccines against COVID-19 infection in healthy and immunosuppressed children and adolescents aged 2–21 years old: a systematic review and meta-analysis

AUTHOR(S)
Sara Sadeghi; Yasamin Kalantari; Sima Shokri (et al.)

Published: July 2022   Journal: Journal of Clinical Virology
Children and adolescents form a large proportion of societies and play an important role in the transmission of COVID-19. On the other hand, their education, mental and physical wellness, and safety are compromised which makes vaccination a crucial step to return to normal life. In the current systematic review, the COVID-19 vaccination was evaluated in a total of 50,148 children and adolescents in 22 published studies and 5,279 participants in two ongoing clinical trials. The study was registered in the PROSPERO with the ID# CRD42022303615. Data were collected about multiple vaccines including BNT162b2 (Pfizer), mRNA-1273 (Moderna), JNJ-78436735 (Johnson and Johnson), CoronaVac (Sinovac), BBIBP-CorV (Sinopharm), adenovirus type-5-vectored vaccine, ZyCov-D, and BBV152 (COVAXIN). The immune response and efficacy of such vaccines were 96% – 100% in healthy children and adolescents and were also acceptable in those with underlying diseases and suppressed immune systems.
COVID-19 vaccine hesitancy and influential factors among Thai parents and guardians to vaccinate their children

AUTHOR(S)
Amornphat Kitro; Wachiranun Sirikul; Ekkamon Dilokkhamaruk (et al.)

Published: July 2022   Journal: Vaccine: X

The ongoing COVID-19 has had a huge worldwide influence. Vaccinations are a crucial component of illness prevention. Thailand's vaccination program for children above the age of five is in its initial stages. Many Thai parents are still unwilling to vaccinate their children with the COVID-19 vaccine. The purpose of this study was to analyze the rate of parental hesitancy and influential variables among Thai parents and guardians living in Thailand. This was a cross-sectional survey in Thailand during October and November of 2021. Through online social media networks, an online survey (REDcap) was distributed. Thai parents and guardians with at least one child under the age of 18 were invited to participate.

Parental COVID-19 vaccine hesitancy in diverse communities: a national survey

AUTHOR(S)
Annabelle de St Maurice; Ray Block; Gabriel Sanchez (et al.)

Published: June 2022   Journal: Academic Pediatrics
This study surveyed a diverse group of US participants to understand parental COVID-19 vaccine hesitancy. It administered a telephone and online survey from May 7-June 7, 2021 using stratified sampling to ensure robust sample sizes of racial and ethnic minorities. Of the 20,280 contacted, 12,288 respondents completed the survey (response rate 61%). It used chi-square tests and adjusted risk ratios to compare results by racial/ethnic group.
Safety and efficacy of COVID-19 vVaccines in children and adolescents: a systematic review of randomized controlled trials

AUTHOR(S)
Fangyuan Tian; Ruonan Yang; Zhaoyan Chen

Published: June 2022   Journal: Journal of Medical Virology
This paper aims to systematically review and synthesize the safety and efficacy of coronavirus disease-2019 (COVID-19) vaccines in children and adolescents. PubMed, EMBASE, Web of Science, Cochrane Library databases, the International Clinical Trials Registry Platform (ICTRP), the Chinese Clinical Trials Registry (ChiCTR), and ClinicalTrials.gov website were searched to collect accessible randomized controlled trials (RCTs) about the safety and efficacy of human COVID-19 vaccines in children and adolescents until May 1, 2022. Three steps, including duplicate removal, title and abstract screening, and full-text review, were used to screen the studies. The Cochrane risk-of-bias tool for RCTs was used to assess the bias risk of the included studies.
Anti-SARS-CoV-2 vaccination campaign: risk perception, emotional states, and vaccine hesitancy in a sample of adolescents' vaccinated parents in Southern Italy

AUTHOR(S)
Giulia Savarese; Luna Carpinelli; Anna De Chiara (et al.)

Published: June 2022   Journal: Vaccines
The international strategic plan for COVID-19 vaccines remains the practical option for the protection of health. However, vaccine hesitancy remains an obstacle to full population vaccination, with rapid developments in COVID-19 vaccines and concerns about efficacy acting as influencing factors. The present study investigated the perception of vaccine hesitancy among parents of adolescents in order to explore the reasons and related emotional states. In January–March 2022, an online questionnaire was administered to a sample of parents who brought their children to the vaccine center of a local health unit, ASL Salerno (Campania, Italy).
Measuring parents' acceptance of non-national immunization program vaccines for children and its influencing factors during the COVID-19 pandemic in Shanghai, China

AUTHOR(S)
Linlin Wu; Zhuoying Huang; Xiang Guo (et al.)

Published: June 2022   Journal: Human Vaccines & Immunotherapeutics
This study aimed to understand the willingness of and affecting factors of non-national immunization program (non-NIP) vaccines among children’s parents during the COVID-19 era in Shanghai, China. A cross-sectional survey was conducted with parents who attended vaccination clinics in four out of 16 districts in Shanghai, China. Data was obtained using a self-administered structured questionnaire. A multivariate logistic regression model was used to analyze factors associated with vaccination acceptability. In total, 1691 valid questionnaires were obtained.
Cite this research | Open access | Vol.: 18 | Issue: 5 | No. of pages: 7 | Language: English | Topics: Health | Tags: COVID-19, immunization, immunization programmes, infectious disease, vaccination, vaccination policies | Countries: China
In whose best interest? Parental hesitancy toward the COVID-19 vaccine for children in Japan: a literature survey study

AUTHOR(S)
Shizuko Takahashi; Eisuke Nakazawa; Akira Akabayashi

Published: June 2022   Journal: COVID
In early February 2022, the Japanese government sent COVID-19 vaccine vouchers to children ages 5–11. Using keywords obtained from the voucher, the frequently asked questions section, and experts, this study descriptively analyzed the advantages and disadvantages of vaccination for children and their parents through a web-based literature survey of media articles and government homepage statements in Japan. For children, vaccination helps prevent severe symptoms and may be particularly beneficial for children in low-income families by lowering the rate of suicide and at-home child abuse. For parents, not vaccinating their child allows them to fulfill a more traditional role as a parent (mothers in particular), reduces the gender gap for mothers, and provides greater peace of mind about their child’s future fertility. This study also examined the governmental vaccination campaigns targeting children from public health perspectives.
Cite this research | Open access | Vol.: 2 | Issue: 7 | No. of pages: 10 | Language: English | Topics: Health | Tags: COVID-19, immunization, immunization programmes, infectious disease, pandemic, vaccination, vaccination policies | Countries: Japan
The impact of COVID-19 pandemic on inequity in routine childhood vaccination coverage: a systematic review

AUTHOR(S)
Nicholas Spencer; Wolfgang Markham; Samantha Johnson (et al.)

Published: June 2022   Journal: Vaccines
Routine childhood vaccination coverage rates fell in many countries during the COVID-19 pandemic, but the impact of inequity on coverage is unknown. This study synthesised evidence on inequities in routine childhood vaccination coverage (PROSPERO, CRD 42021257431). Studies reporting empirical data on routine vaccination coverage in children 0–18 years old during the COVID-19 pandemic by equity stratifiers were systematically reviewed. Nine electronic databases were searched between 1 January 2020 and 18 January 2022.
Pediatric and adolescent COVID‐19 vaccination side effects: a retrospective cohort study of Iranian teenage group in 2021

AUTHOR(S)
Nader Tavakoli; Nahid Nafissi; Sima Shokri (et al.)

Published: June 2022   Journal: Journal of Medical Virology
This study aimed to determine the safety and efficacy profile of teenager COVID-19 vaccination. In this retrospective cohort study, contact numbers of parents of teenagers under 18 years of age referred to a teenager vaccination centers in Tehran-Iran to receive the corona vaccine were collected, and the following information was obtained via the phones: demographic information, type of vaccine, and the number of doses received, as well as additional information like complications and required treatments. Eleven thousand forty-two subjects aged 10−18 years, mean age 14.55 ± 1.83 year  including 5374 boys and 5768 girls were investigated.
COVID-19 vaccine counseling and safety assessment in children and teenagers with underlying medical conditions in China: a single center study

AUTHOR(S)
Mei Zeng; Xiaowen Zhai; Hailing Chang (et al.)

Published: June 2022   Journal: Human Vaccines & Immunotherapeutics
Safety concerns about novel vaccines and necessity of COVID-19 vaccination for children, especially with underlying medical conditions, are the obstacle of COVID-19 vaccination program among pediatric population. The study was conducted to investigate the vaccine hesitancy reasons among the parents, and to monitor the adverse events of inactivated COVID-19 vaccines in children and teenagers with underlying medical conditions in China. Children with underlying medical conditions encountered to the Immunization Advisory Clinic for COVID-19 vaccine counseling were enrolled. They were given immunization recommendation and followed up at 72 h and 28 d after immunization to monitor the immunization compliance after consultation and adverse events. A total of 324 children aged 3–17 y were included. The top three primary medical conditions for counseling were allergy (33.6%), neurological diseases (31.2%) and rheumatic diseases (8.3%). COVID-19 vaccination was promptly recommended for 242 (74.7%) children. Seventy-one (65.7%) children who had allergy issues were recommend to take vaccination, which was significantly lower than that of other medical conditions (p < .05).
Factors influencing parents' willingness to vaccinate their preschool children against COVID-19: results from the mixed-method study in China

AUTHOR(S)
Mengmou Zheng; Wanzhen Zhong; Xiyue Chen (et al.)

Published: June 2022   Journal: Human Vaccines & Immunotherapeutics
During the COVID-19 pandemic, little is known about parental hesitancy to receive the COVID-19 vaccine for preschool children who are the potential vaccinated population in the future. The purpose of this mixed-method study was to explore the factors influencing Chinese parents’ decision to vaccinate their children aged 3–6 years old against COVID-19. In July 2021,  semi-structured interviews (n = 19) and a cross-sectional survey (n = 2605) were conducted with parents of kindergarten children in an urban-rural combination pilot area in China. According to the qualitative study, most parents were hesitant to vaccinate their children with the COVID-19 vaccine.
Awareness, barriers and concerns of adolescents toward the COVID-19 vaccine: a cross-sectional study in Singapore

AUTHOR(S)
Prawira Oka; Benecia Wan Qing Thia; Shyna Zhuoying Gunalan (et al.)

Published: June 2022   Journal: Frontiers in Public Health

COVID-19 vaccination is a key public health measure to mitigate the crippling effects of the pandemic. COVID-19 vaccination began in adults and targeted adolescents at a later stage. However, medical decision-making on its uptake among the latter was unknown, which could be affected by their literacy and concerns about the vaccine. The study aimed to elucidate the awareness, concerns and barriers of adolescents toward the COVID-19 vaccine. A cross-sectional online survey using a self-developed questionnaire was conducted between June to November 2021. The adolescent participants were students from institutes of post-secondary education who were recruited via convenience sampling. The data were collated from an officially approved electronic platform, audited and analyzed. Continuous and categorical variables were expressed as mean (standard deviation) and percentages, respectively.

The willingness of parents to vaccinate their children younger than 12 years against COVID-19: a cross-sectional study in Malaysia

AUTHOR(S)
Diana-Leh-Ching Ng; Gin-Gin Gan; Chee-Shee Chai (et al.)

Published: June 2022   Journal: BMC Public Health volume

The initiation of a new drug, for instance, the coronavirus disease 2019 (COVID-19) vaccine in children could be a source of major concern for parents. This study aims to determine the willingness of parents in Malaysia to vaccinate their children younger than 12 years against COVID-19. An online cross-sectional survey was conducted nationwide in Malaysia from August 29, 2021, to October 17, 2021. Parents with children younger than 12 years were enrolled via the snowball sampling method.

Short-term side effects and SARS-CoV-2 infection after COVID-19 Pfizer–BioNTech vaccine in children aged 5–11 years: an Italian real-world study

AUTHOR(S)
Martina Capponi; Federica Pulvirenti; Bianca Laura Cinicola (et al.)

Published: June 2022   Journal: Vaccines
Vaccination against COVID-19 is the most effective tool to protect both the individual and the community from this potentially life-threatening infectious disease. Data from phase-3 trials showed that two doses of the BNT162b2 vaccine were safe, immunogenic, and effective against COVID-19 in children aged 5–11 years. However, no surveys in real-life settings have been carried out in this age range. This is a cross-sectional study which aims to evaluate the short-term adverse reactions (ARs) and the rate of protection against infection of the BNT162b2 vaccine in children aged 5–11 years by the compilation of two surveillance questionnaires conceived using Google Forms.
Safety monitoring of COVID-19 vaccination among adolescents aged 12 to 17 years old in the Republic of Korea

AUTHOR(S)
Seontae Kim; Insob Hwang; Mijeong Ko (et al.)

Published: June 2022   Journal: Osong Public Health and Research Perspectives

This study aimed to disseminate information on coronavirus disease 2019 (COVID-19) vaccine safety among adolescents aged 12 to 17 years in the Republic of Korea. Two databases were used to assess COVID-19 vaccine safety in adolescents aged 12 to 17 years who completed the primary Pfizer-BioNTech vaccination series. Adverse events reported to the web-based COVID-19 vaccination management system (CVMS) and collected in the text message-based system were analyzed.

151 - 165 of 342

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UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.