Children and COVID-19 Research Library

Obesity is a well-recognized risk factor for critical illness and death among adult patients with SARS-CoV-2 infection. This study aimed to characterize the clinical outcomes and risk factors of death related to obesity in a cohort of hospitalized paediatric patients with COVID-19. It performed an analysis of all paediatric patients with obesity and COVID-19 registered in SIVEP-Gripe, a Brazilian nationwide surveillance database, between February 2020 and May 2021. The primary outcome was time to death, which was evaluated by using cumulative incidence function.

Parents of the COVID -19 positive hospitalized children are facing different psychological stresses which are affecting child’s care and well-being.
This study aims to determine the psychological stress, anxiety and depression and to identify the associated influencing factors in mothers of hospitalized COVID-19 infected children. In this cross-sectional observational study, 150 mothers of COVID-19 positive hospitalized children in a paediatric tertiary care hospital were randomly selected and studied. Data collection tool was a two part questionnaire; the first part was based on ‘Perceived stress scale-10’ and ‘Hospital anxiety and depression scale’ and the second part included stressors related to COVID-19 pandemic selected based on previous researches. The incidence of these stressors and their significance in causing stress, anxiety and depression was assessed using standard statistical methods.

As the epidemic progresses, universal vaccination against COVID-19 has been the trend, but there are still some doubts about the efficacy and safety of COVID-19 vaccines in adolescents, children, and even infants. This study aims to evaluate the safety, immunogenicity, and efficacy of COVID-19 vaccines in the population aged 0–17 years. A comprehensive search for relevant randomized controlled trials (RCTs) was conducted in PubMed, Embase, and the Cochrane Library from inception to November 9, 2021. All data were pooled by RevMan 5.3 statistical software, with risk ratio (RR) and its 95% confidence interval as the effect measure. This study protocol was registered on PROSPERO (CRD42021290205).

In women affected by other coronavirus infections such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV), the mortality rate appeared higher in women affected in pregnancy compared with non-pregnant women. COVID-19 prompted implementation of public health protocols to control the transmission of the virus, many of them required social distancing, hand washing, and lockdown procedures, but has also resulted in creating public anguish and massive fear, especially among the unaffected persons. Objectives: To assess pregnant women's knowledge about who can protect the baby during Brest feeding when mother infected by corona virus before and after implementation of instruction program and to determine the effectiveness of instruction program on pregnant women knowledge about protection methods of neonate during pandemic.

Rapid Advice Guidelines (RAG) provide decision makers with guidance to respond to public health emergencies by developing evidence-based recommendations in a short period of time with a scientific and standardized approach. However, the experience from the development process of a RAG has so far not been systematically summarized. Therefore, this working group will take the experience of the development of the RAG for children with COVID-19 as an example to systematically explore the methodology, advantages, and challenges in the development of the RAG. It shall propose suggestions and reflections for future research, in order to provide a more detailed reference for future development of RAGs.

Limited data are available on the attitudes of caregivers toward COVID-19 vaccination in children and adolescents with a history of SARS-CoV-2 infection or Long Covid symptoms. The aim of this study was to investigate the vaccine hesitancy among caregivers of children and adolescents with a documented history of SARS-CoV-2 infection and to explore the possible associations between COVID-19 manifestations and the acceptance of the vaccine. Caregivers of children or adolescents with a microbiologically confirmed diagnosis of SARS-CoV-2 infection evaluated in two University Hospitals were interviewed.

Since viral infections are one of the most important factors affecting asthma control, various precautions and recommendations for asthma patients came to the fore at the beginning of the COVID-19 pandemic. This study, aimed to evaluate the effects of the COVID-19 pandemic on asthma control and treatment steps of children with asthma.

Whether long coronavirus disease pertains to children as well is not yet clear. The authors performed a survey in children suffering from persistent symptoms since initial infection. A total of 510 children infected between January 2020 and January 2021 were included.

The corona virus disease (SARS-CoV-2) has rapidly spread across the world and global population including children are facing unprecedented health crisis. The chance of vertical and perinatal transmission of SARS-CoV-2 virus in children is not proven yet. The effect of the virus on neonate and infant appears to be small. On the other hand, pregnant women suffering from corona virus disease may give birth to premature or IUGR babies who will need extra care. Breast feeding is considered as gold standard in almost all situation. Continuation of breast feeding along with other essential services have reduced the risk of transmission of corona virus.

There is a scarcity of population-level data of pediatric COVID-19 infection from Southeast Asia. This study aims to describe and compare epidemiological, clinical, laboratory and outcome data among pediatric COVID-19 cases versus controls in two neighboring countries, Singapore and Malaysia. It used a test-negative case–control study design recruiting all suspected COVID-19 cases (defined by either clinical or epidemiological criteria) from January 2020to March 2021 admitted to two main pediatric centers in Singapore and Malaysia. Data were collected using a standardized registry (Pediatric Acute and Critical Care COVID-19 Registry of Asia).

The effects of COVID-19 on children are still poorly understood. Considering the progressive increase in pediatric cases, we sought to gather evidence of the disease in children, to better understand its evolution, possible complications, and favor clinical practice. This is a review, whose search was carried out in the National Library of Medicine, Latin American & Caribbean Health Sciences Literature (LILACS), Medical Literature Analysis and Retrieval System Online, Virtual Health Library (BVS), PAHO and Cochrane Library. Eight articles were included, and the most common symptoms described were: cold-like symptoms, dry cough, respiratory difficulty, mild throat infection, loss of muscle strength, tonic and reflex changes in the lower limbs. However, there is still no clarity about the disease in children, requiring further research.

This study explores the link between regular grandparental childcare and SARS-CoV-2 infection rates at the level of German counties. This analysis suggests that a region’s infection rates are shaped by region-, household- and individual-specific parameters. It extensively draws on the latter, exploring the intra- and extra-familial mechanisms fuelling individual contact frequency to test the potential role of regular grandparental childcare in explaining overall infection rates.