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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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16 - 30 of 238
Emergency and disaster response strategies to support maternal-infant dyads in times of COVID

Felipe Aros-Vera; Ilana R. Azulay Chertok; Semyon Melnikov

Published: August 2021   Journal: International Journal of Disaster Risk Reduction
The COVID-19 pandemic has produced an unprecedented global health crisis. Vulnerable populations, such as breastfeeding mother-infant dyads, are in a particularly delicate situation. Before, during, and after birth mothers and their infants could be exposed to the virus. Due to fear of infection transmission, there has been an increase in separation of COVID-positive mothers and their infants and a decline in breastfeeding, despite research supporting the provision of mother's milk for her infant. During this crisis, evidence-based education counseling and resources can support healthful infant feeding which is necessary for short- and long-term infant growth and development. Using a framework of disaster preparedness and response, this study delineates operational guidelines and policy recommendations to support maternal-infant dyads during the COVID pandemic outbreak. Key recommendations include promotion of breastfeeding and milk expression, avoiding the use of formula, engaging healthcare providers in supporting lactation, and incorporating evidence-based breastfeeding and lactation protocols and practices in disaster preparedness and disaster response plans.
COVID-19 hospitalization rate in children across a private hospital network in the United States

Tommy Y. Kim; Esther C. Kim; Adrian Z. Agudelo (et al.)

Published: August 2021   Journal: Archives de Pédiatrie

There are limited studies with varying results evaluating the rate of hospitalizations of pediatric patients tested for COVID-19 in the United States. More information in the pediatric COVID-19 literature is needed. The objective of this study was to describe the rates of positive tests, hospitalization, severe disease, and mortality for COVID-19 in children. This study performed a retrospective analysis of data collected from a data warehouse from 184 hospitals across the United States. All cases of pediatric patients who were tested for COVID-19 were analyzed for test positivity, hospitalization, severe disease, and mortality. A separate subgroup analysis for ages < 1 year, 1–4 years, 5–8 years, 9–14 years, and 15–17 years was performed.

Socioeconomic inequalities in low birth weight risk before and during the COVID-19 pandemic in Argentina: a cross-sectional study

Eduardo Cuestas; Martha E. Gómez-Flores; María D. Charras (et al.)

Published: August 2021   Journal: The Lancet Regional Health - Americas

The coronavirus disease 2019 (COVID-19) pandemic may have exacerbated existing socioeconomic inequalities in health. In Argentina, public hospitals serve the poorest uninsured segment of the population, while private hospitals serve patients with health insurance. This study aimed to assess whether socioeconomic inequalities in low birth weight (LBW) risk changed during the first wave of the COVID-19 pandemic. This multicenter cross-sectional study included 15929 infants. A difference-in-difference (DID) analysis of socioeconomic inequalities between public and private hospitals in LBW risk in a pandemic cohort (March 20 to July 19, 2020) was compared with a prepandemic cohort (March 20 to July 19, 2019) by using medical records obtained from ten hospitals.

Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study

Sheena Mukkada; Nickhill Bhakta; Guillermo L. Chantada (et al.)

Published: August 2021   Journal: The Lancet Oncology

Previous studies have shown that children and adolescents with COVID-19 generally have mild disease. Children and adolescents with cancer, however, can have severe disease when infected with respiratory viruses. In this study, we aimed to understand the clinical course and outcomes of SARS-CoV-2 infection in children and adolescents with cancer. We did a cohort study with data from 131 institutions in 45 countries. We created the Global Registry of COVID-19 in Childhood Cancer to capture de-identified data pertaining to laboratory-confirmed SARS-CoV-2 infections in children and adolescents (<19 years) with cancer or having received a haematopoietic stem-cell transplantation. There were no centre-specific exclusion criteria. The registry was disseminated through professional networks through email and conferences and health-care providers were invited to submit all qualifying cases. Data for demographics, oncological diagnosis, clinical course, and cancer therapy details were collected.

Stigma, guilt and motherhood: experiences of pregnant women with COVID-19 in Brazil

Juliana Vasconcellos Freitas-Jesus; Odette Del Risco Sánchez; Larissa Rodrigues (et al.)

Published: August 2021   Journal: Women and Birth

The COVID-19 pandemic raises health issues worldwide. Infected pregnant women may have negative mental health outcomes, but little is known about their emotional experiences.This study aimed to understand the experience of women infected with COVID-19 during pregnancy, regarding their feelings, their relationships, and the influence of social media.

Vaccine hesitancy towards childhood immunizations as a predictor of mothers’ intention to vaccinate their children against COVID-19 in Saudi Arabia

Haifa Aldakhil; Norah Albedah; Nouf Alturaiki (et al.)

Published: August 2021   Journal: Journal of Infection and Public Health

Despite the success of childhood immunization in reducing vaccine-preventable diseases, vaccine hesitancy is now a global health threat to this achievement. The current COVID-19 pandemic may change the picture of vaccine hesitancy toward childhood immunizations, which could influence the mothers’ intention to vaccinate their children against COVID-19. This study aims to measure the prevalence and related factors of vaccine hesitancy towards childhood immunization during the era of COVID-19 along with the prevalence of mothers’ intention to vaccinate their children the future COVID-19 and its association with childhood vaccine hesitancy.

COVID-19 in pregnancy: what we know from the first year of the pandemic

Anya Lara Arthurs; Tanja Jankovic-Karasoulos; Claire Trelford Roberts

Published: August 2021   Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

The COVID-19 pandemic has infected nearly 178 million people and claimed the lives of over 3.8 million in less than 15months. This has prompted a flurry of research studies into the mechanisms and effects of SARS-CoV-2 viral infection in humans. However, studies examining the effects of COVID-19 in pregnant women, their placentae and their babies remain limited. Furthermore, reports of safety and efficacy of vaccines for SARS-CoV-2 in pregnancy are limited. This review concisely summarises the case studies and research on COVID-19 in pregnancy, to date. It also reviews the mechanism of infection with SARS-CoV-2, and its reliance and effects upon the renin-angiotensin-aldosterone system.

Factors affecting parent health-promotion behavior in early childhood according to family cohesion: Focusing on the COVID-19 pandemic

Song I. Parka; In Young Chob

Published: August 2021   Journal: Journal of Pediatric Nursing

This study investigated and compared the factors influencing parents' promotion of healthy behavior in young children according to their family cohesion level during the COVID-19 pandemic in South Korea. This was a cross-sectional study involving 432 parents of young children (ages 1–6) in six South Korean cities (320 and 112 from the high and low family cohesion groups, respectively). We collected data using self-report questionnaires on parents' health promotion behavior, stress, risk perception due to COVID-19, positive psychological capital, and family cohesion, and analyzed it using stepwise multiple regressions with the SPSS program.

Vitamin D levels in children with COVID-19: a report from Turkey

Aysegul Alpcan; Serkan Tursun; Yaşar Kandur (et al.)

Published: August 2021   Journal: Epidemiology & Infection
Several studies have demonstrated that higher levels of vitamin D are associated with better prognosis and outcomes in infectious diseases. This study aimed to compare the vitamin D levels of paediatric patients with mild/moderate coronavirus disease 2019 (COVID-19) disease and a healthy control group. It retrospectively reviewed the medical records of patients who were hospitalised at our university hospital with the diagnosis of COVID-19 during the period between 25 May 2020 and 24 December 2020.
Cite this research | No. of pages: 4 | Language: English | Topics: Health | Tags: child health, COVID-19, hospitalization, infectious disease | Countries: Turkey
Willingness and influential factors of parents of 3-6-year-old children to vaccinate their children with the COVID-19 vaccine in China

Xiao Wan; Haitao Huang; Jia Shang (et al.)

Published: August 2021   Journal: Human Vaccines & Immunotherapeutics
The impact of Coronavirus disease 2019 (COVID-19) on children aged 3–6 can be severe. Vaccination for COVID-19 is one of the most important primary preventative measures to reduce disease transmission. Parents are hesitant to vaccinate their children against COVID-19 because it was reported in the news that some adults have had adverse reactions to the vaccine. This study aims to investigate the willingness of Chinese parents of 3–6 year old children to vaccinate them with the COVID-19 vaccine and identify what factors influence their decisions. A survey was conducted using a two-stage stratified random sampling method from December 2020 to February 2021. We used univariate analysis and multivariate binary logistic analysis to explore potential factors that may determine the acceptance of the COVID-19 vaccine.
Repurposing of the childhood vaccines: could we train the immune system against the SARS-CoV-2

Divakar Sharma

Published: August 2021   Journal: Expert Review of Vaccines

The COVID-19 pandemic is a globalized health concern caused by a beta-coronavirus named Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Since December 2019, when this outbreak flared in Wuhan, China, COVID-19 cases have been continuously rising all over the world. Due to the emergence of SARS-CoV-2 mutants, subsequent waves are flowing in a faster manner as compared to the primary wave, which is more contagious and causing higher mortality. Recently, India has emerged as the new epicenter of the second wave by mutants of SARS-CoV-2. After almost eighteen months of this outbreak, some COVID-19 dedicated therapeutics and vaccines are available, and a few are under trial, but the situation is still uncontrolled. This perspective article covers the repurposing of childhood vaccines like Bacille Calmette–Guerin (BCG), Measles, Mumps, Rubella (MMR), and Oral Polio Vaccine (OPV), which are live attenuated vaccines and have been shown the protective effect through ‘trained immunity and ‘crossreactivity.'

Determinants of parental hesitancy to vaccinate their children against COVID-19 in China

Mei-Xian Zhang; Xiao-Qing Lin; Yan Chen (et al.)

Published: August 2021   Journal: Expert Review of Vaccines

Vaccine hesitancy seriously hinders herd immunity. This study explored the determinants of parental hesitancy to vaccinate children against Coronavirus Disease 2019 (COVID-19) in China. A population-based self-administered online questionnaire evaluating parental hesitancy in vaccinating their children against COVID-19 was conducted in Taizhou, China. Of the 2463 parents who received the invitation, 1788 (72.6%) responded to the survey.

Breastfeeding in the era of COVID-19: a narrative review

Rozeta Sokou; Aikaterini Konstantinidi; Theodora Boutsikou (et al.)

Published: August 2021   Journal: Journal of Obstetrics and Gynaecology
Human milk is the best possible nutrition for infants, as it supplies them with nutrients, bioactive molecules as well as antibodies, which contribute to immune maturation, organ development, and healthy microbial colonisation. Few situations are considered definitive contraindications for breastfeeding. The disastrous Coronavirus Disease-2019 (COVID-19) pandemic raised many health issues, including the safety of breastfeeding for infants born to affected mothers. To date relevant data are limited. This review will make an account of the published data so far, regarding the transmission risk of SARS-CoV-2 via human milk; it will also present the current feeding recommendations, issued by several international boards, though not always in agreement, for infants born to mothers suspected or positive for SARS-CoV-2. In most studies existing so far on women with COVID-19, the virus was not detected in breastmilk. Based on currently available data, it seems that breastfeeding and human milk are not contraindicated for infants born to mothers suspected or confirmed with COVID-19.
Acceptance and willingness to pay for COVID-19 vaccines among pregnant women in Vietnam

Long Hoang Nguyen; Men Thi Hoang; Lam Duc Nguyen (et al.)

Published: August 2021   Journal: Tropical Medicine & International Health

The aim of this study was to assess acceptance of COVID-19 vaccination and the willingness to pay (WTP) for it, and investigate associated factors among pregnant women in Vietnam.Cross-sectional survey of pregnant women in two obstetric hospitals in Hanoi and Ca Mau provinces, Vietnam. Data on acceptance and WTP for COVID-19, demographic characteristics, maternal characteristics, and risk perceptions toward COVID-19 were collected. Multivariate logistic and linear regression models were performed to identify factors associated with the acceptance and WTP for the vaccine.

Pediatric and parents' attitudes towards COVID-19 vaccines and intention to vaccinate for children

Soo-Han Choi; Yoon Hee Jo; Kyo Jin Jo (et al.)

Published: August 2021   Journal: Journal of Korean Medical Science

Coronavirus disease 2019 (COVID-19) vaccination is necessary to reach herd immunity and essential for mitigating the spread of the pandemic. In May 2021, the US FDA and the EU have expanded the emergency use authorization for a COVID-19 vaccine to children aged 12 to 15. The aim of this study was to investigate parental acceptability of COVID-19 vaccination for their children, factors affecting their acceptability, and children's perceptions of COVID-19 vaccines in Republic of Korea. A questionnaire survey at two tertiary hospitals was conducted from May 25, 2021 to June 3, 2021. Subjects were parents having children under 18 years and children aged 10–18 years.

16 - 30 of 238

UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.