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Children and COVID-19 Research Library

UNDER DEVELOPMENT UNICEF Innocenti's curated library of COVID-19 + Children research

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High rates of antibiotic prescriptions in children with COVID‐19 or multisystem inflammatory syndrome: a multinational experience in 990 cases from Latin America

AUTHOR(S)
Adriana Yock- Corrales; Jacopo Lenzi; Rolando Ulloa- Gutiérrez (et al.)

Published: March 2021   Journal: Acta Paediatrica

This study aims to assess rates of antibiotic prescriptions and its determinants in in children with COVID‐19 or Multisystem Inflammatory Syndrome (MIS‐C). Children <18 years‐old assessed in five Latin Americas countries with a diagnosis of COVID‐19 or MIS‐C were enrolled. Antibiotic prescriptions and factors associated with their use were assessed.


Cite this research | Open access | No. of pages: 9 | Language: English | Topics: Health | Tags: child health, COVID-19, multi-country, pharmaceuticals
The effects of opioids on female fertility, pregnancy and the breastfeeding mother‐infant dyad: a review

AUTHOR(S)
Daniel J. Corsi; Malia S. Q. Murphy

Published: February 2021
Rates of opioid use and opioid agonist maintenance treatment have increased substantially in recent years, particularly among women. Trends and outcomes of opioids use on fertility, pregnancy and breastfeeding, and longer‐term child developmental outcomes have not been well‐described. This paper reviews the existing literature on the health effects of opioid use on female fertility, pregnancy, breastmilk and the exposed infant. It finds that the current literature is primarily concentrated on the impact of opioid use in pregnancy and neonatal outcomes, with little exploration of effects on fertility. Studies are limited in number, some with small sample sizes, and many are hampered by methodological challenges related to confounding and other potential biases. Opioid use is becoming more prevalent due to environmental pressures such as COVID‐19.
Rates of opioid use and opi-
oid agonist maintenance treatment have increased substantially in recent years, par-
ticularly among women. Trends and outcomes of opioids use on fertility, pregnancy
and breastfeeding, and longer- term child developmental outcomes have not been
well- described. Here, we review the existing literature on the health effects of opioid
use on female fertility, pregnancy, breastmilk and the exposed infant. We find that
the current literature is primarily concentrated on the impact of opioid use in preg-
nancy and neonatal outcomes, with little exploration of effects on fertility. Studies
are limited in number, some with small sample sizes, and many are hampered by
methodological challenges related to confounding and other potential biases. Opioid
use is becoming more prevalent due to environmental pressures such as COVID- 19.
Safety of tocilizumab in COVID‐19 pregnant women and their newborn: a retrospective study

AUTHOR(S)
Inés Jiménez‐Lozano; José Manuel Caro‐Teller; Nuria Fernández‐Hidalgo (et al.)

Published: February 2021   Journal: Journal of Clinical Pharmacy and Therapeutics
Tocilizumab is an IL‐6 receptor inhibitor agent which has been proposed as a candidate to stop the inflammatory phase of infection by the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). However, safety data of tocilizumab in pregnant women and their newborn are scarce. This study aimed to describe maternal and neonatal safety outcomes associated with tocilizumab treatment in pregnant women with severe COVID‐19.
Serious infectious events and ibuprofen administration in pediatrics: a narrative review in the era of COVID-19 pandemic

AUTHOR(S)
Lucia Quaglietta; Massimo Martinelli; Annamaria Staiano

Published: January 2021   Journal: Italian Journal of Pediatrics
Despite its recognized efficacy and tolerability profile, during the last decade a rise of adverse events following ibuprofen administration in children has been reported, including a possible role in worsening the clinical course of infections. Our aim was to critically evaluate the safety of ibuprofen during the course of pediatric infectious disease in order to promote its appropriate use in children.
Changes in maternal substance use during the COVID-19 pandemic

AUTHOR(S)
Kayla M. Joyce; Emily Cameron; Julia Sulymka (et al.)

Published: September 2020
Mothers may be at risk for increasing substance use during the COVID-19 pandemic which could lead to negative health consequences for the mother herself as well as her developing child. This study aims to examine group differences between mothers reporting decreased, increased, or no change to their substance use and identify risk and protective factors that influence retrospectively-reported changes in substance use during the COVID-19 pandemic in a sample of mothers with young children.
COVID-19: a review of drugs and therapies for children

AUTHOR(S)
Patel Zeeshan Jameel; Amar M. Taksande

Published: September 2020   Journal: Sri Lanka Journal of Child Health
A review of drugs and therapy for children including: respiratory support, nutritional supplementation, immunotherapy, CoV specific therapy, chloroquine, antiviral therapy, antibiotics, anti-parasitic drugs
Cite this research | Open access | Vol.: 49 | Issue: 3 | No. of pages: 210-217 | Language: English | Topics: Health | Tags: child health, medical care, pharmaceuticals
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UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.

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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.