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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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1 - 15 of 54
Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study

Sheena Mukkada; Nickhill Bhakta; Guillermo L. Chantada (et al.)

Published: August 2021   Journal: The Lancet Oncology

Previous studies have shown that children and adolescents with COVID-19 generally have mild disease. Children and adolescents with cancer, however, can have severe disease when infected with respiratory viruses. In this study, we aimed to understand the clinical course and outcomes of SARS-CoV-2 infection in children and adolescents with cancer. We did a cohort study with data from 131 institutions in 45 countries. We created the Global Registry of COVID-19 in Childhood Cancer to capture de-identified data pertaining to laboratory-confirmed SARS-CoV-2 infections in children and adolescents (<19 years) with cancer or having received a haematopoietic stem-cell transplantation. There were no centre-specific exclusion criteria. The registry was disseminated through professional networks through email and conferences and health-care providers were invited to submit all qualifying cases. Data for demographics, oncological diagnosis, clinical course, and cancer therapy details were collected.

Evaluation of predictors of severe-moderate COVID-19 infections at children: a review of 292 children

Aybüke A. Kara; Elif Böncüoğlu; Elif Kıymet

Published: July 2021   Journal: Journal of Medical Virology
Although the underlying disease is associated with a severe course in adults and laboratory abnormalities have been widely reported, there are not sufficient data on the clinical course of coronavirus disease 2019 (COVID-19) in children with pre-existing comorbid conditions and on laboratory findings. This study aimed to describe the independent risk factors for estimating the severity of the COVID-19 in children. All children between 1 month and 18 years old who were hospitalized during the period of March 11–December 31, 2020, resulting from COVID-19 were included in the study. Patients were categorized into mild (group 1) and moderate + severe/critically (group 2) severity based on the criteria. Demographic characteristics, comorbidities, and laboratory variables between the two groups were compared. A total of 292 children confirmed to have COVID-19 infection were included in the study.
SARS-CoV-2 antibodies started to decline just four months after COVID-19 infection in a paediatric population

Adin Breuer; Allon Raphael; Hagay Stern (et al.)

Published: July 2021   Journal: Acta Paediatrica

This study evaluated the prevalence of paediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections using antibody testing and characterised antibody titres by time from exposure. This was a single-centre, prospective, cross-sectional cohort study. Patients under 18 years old were eligible to participate if they attended the paediatric emergency department at the tertiary Shaare Zedek Medical Center, Jerusalem, Israel, from 18 October 2020 to 12 January 2021 and required blood tests or intravenous access. SARS-CoV-2 seropositivity and antibody levels were tested by a dual-assay model.

Impact of nonpharmacological COVID-19 interventions in hospitalizations for childhood pneumonia in Brazil

Frederico Friedrich; Laura de Castro e Garcia; Lucas Montiel Petry (et al.)

Published: July 2021   Journal: Pediatric Pulmonology

The knowledge about the impact of the nonpharmacological measures to control the COVID-19 pandemic can give insight into ways in which they can also be applied for other respiratory diseases. To assess the impact of containment measures of the COVID-19 pandemic on pneumonia hospitalizations in children from 0 to 14 years of age in Brazil. Data from hospital admissions for pneumonia were obtained from the Department of Informatics of Brazilian Public Health System database in the period of 2015–2020 and analyzed by macroregions and age groups. To evaluate the effect of containment measures, on the incidence of pneumonia, the absolute reduction and relative reduction were calculated by analyzing the subsets 2015-2019 vs. 2020.

Children and SARS-CoV-2

Dusan Bogunovic; Miriam Merad

Published: July 2021   Journal: Cell Host & Microbe
A previously immune-naive world population is experiencing natural infection with SARS-CoV-2. Severe COVID-19 predominantly impacts adults, yet multisystem inflammatory disorder primarily impacts children. Herein, this article discusses known clinical and biological features of SARS-CoV-2 in children and reflects on currently identified immune features and discusses what remains unknown.
Cite this research | Open access | Vol.: 29 | Issue: 7 | No. of pages: 1040-1042 | Language: English | Topics: Health | Tags: child health, COVID-19, disease transmission, infectious disease, medical research, respiratory diseases
Ongoing asthma management in children during the COVID-19 pandemic: to step down or not to step down?

Elissa Michele Abrams; Stanley Szefler

Published: July 2021   Journal: The Lancet Respiratory Medicine
A substantial reduction in asthma exacerbations in both children and adults has been seen in many countries worldwide during the COVID-19 pandemic. The cause of this reduction is likely to be multifactorial, but at least partly due to population-level public health measures, such as physical distancing, masking, and hand washing, which reduce broad viral transmission. This improvement in asthma control poses an interesting clinical dilemma: should clinicians consider tapering asthma medications in children during the pandemic in the face of good asthma control? Furthermore, if medicines are reduced during the COVID-19 pandemic, should clinicians return to the pre-COVID-19 schedule as respiratory precautions are gradually relaxed?
COVID-19 and the mental health of children with respiratory illness

Ian P. Sinha; Ruth Murphy; Holly Biffin (et al.)

Published: July 2021   Journal: The Lancet Respiratory Medicine
Children and young people have been deeply affected by the COVID-19 pandemic. Lockdowns and new ways of living have necessitated massive adjustments. Despite heroic efforts from teachers, there has been a huge impact on education, and children lost the psychosocial benefits of being in school. News coverage is incessant, and polarised narratives and opinions are amplified in social media echo-chambers. In this report, co-authored with an adolescent from our clinic, we discuss the psychological impact of the COVID-19 pandemic on children and young people with respiratory problems.
Knowledge and preventive practices towards COVID-19 among pregnant women seeking antenatal services in Northern Ghana

Maxwell Tii Kumbeni; Paschal Awingura Apanga; Eugene Osei Yeboah (et al.)

Published: June 2021   Journal: Plos One
COVID-19 is a novel respiratory disease associated with severe morbidity and high mortality in the elderly population and people with comorbidities. Studies have suggested that pregnant women are more susceptible to COVID-19 compared to non-pregnant women. However, it’s unclear whether pregnant women in Ghana are knowledgeable about COVID-19 and practice preventive measures against it. This study sought to assess the knowledge and preventive practices towards COVID-19 among pregnant women seeking antenatal services in Northern Ghana
Impact of COVID-19 lockdown on children with asthma in Jordan: a parental questionnaire

Montaha Al-Iede; Karen Waters; Shereen M Aleidi (et al.)

Published: June 2021   Journal: BMJ Paediatrics Open

This paper aims to evaluate the impact of a 10-week lockdown on children with asthma aged 4–17 years in terms of presentations to the emergency department (ED), frequency of admissions, compliance with medications and changes in pulmonary function testing results. It is a questionnaire-based cross-sectional study using Google Forms to collect parents’ and caregivers’ responses after they consented to participation.

Cite this research | Open access | Vol.: 5 | Issue: 1 | No. of pages: 6 | Language: English | Topics: Health | Tags: child health, COVID-19, health services, infectious disease, respiratory diseases | Countries: Jordan
Comparative study of hospitalized children with acute respiratory distress syndrome caused by SARS-CoV-2 and influenza virus

Xinghua Liu; Wei Li; Bo Zhang (et al.)

Published: May 2021   Journal: BMC Infectious Diseases
Since the outbreak of coronavirus disease 2019 in December 2019, more than 8 million cases have occurred worldwide as of June 16, 2020. However, it is important to distinguish COVID-19 from other respiratory infectious diseases, such as influenza. Here, we comparatively described the clinical characteristics of children with COVID-19 and paediatric patients with influenza.
Relationship of COVID-19 with pregnancy

Umme Salma

Published: May 2021   Journal: Taiwanese Journal of Obstetrics and Gynecology
COVID-19 a pandemic disease caused by the SARS-CoV2 virus, which has been emerged in Wuhan city China from early December 2019 which subsequently spreading globally. As a consequence of the physiological adaptive changes and immunosuppressive condition during pregnancy are more susceptible to respiratory tract infection and pneumonia that perhaps makes them more at risk to COVID-19.There is scarce information available on COVID-19 pregnancy and no reliable evidence for vertical transmission. It is a concern that newborns are risk from postpartum contamination. Meanwhile, there was no vaccine and specific therapeutic drugs for COVID19.
Cite this research | Open access | Vol.: 60 | No. of pages: 405-411 | Language: English | Topics: Health | Tags: COVID-19, disease transmission, pregnancy, pregnant women, respiratory diseases
Pediatric TB detection in the era of COVID-19

Javeed A. Golandaj

Published: May 2021   Journal: Indian Journal of Tuberculosis
The effect of COVID-19 and measures in response to it on human lives was enormous, including healthcare. The necessary healthcare services including communicable diseases, such as Tuberculosis (TB) were badly affected. Here an attempt has been made to trace the number of notified Pediatric TB cases during and after COVID-19 lockdown and unlock period, and then compared with same period of previous year.
COVID-19 and pregnancy: risk, symptoms, diagnosis, and treatment

Vera Hapshy; Daniel Aziz; Payal Kahar (et al.)

Published: April 2021   Journal: SN Comprehensive Clinical Medicine
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus responsible for causing an infection known as COVID-19. Several pulmonary and systemic manifestations of the illness have been described since the discovery of this virus. However, there have been higher-risk populations in which this infection has not been well studied nor documented. One of these populations includes the pregnant cohort. The purpose of this article is to describe the clinical manifestations of COVID-19 infection in the pregnant population and review the implications and sequelae of the infection throughout pregnancy and outcomes of live births. Also, we summarize the understanding and safety of current treatments and vaccination in pregnancy. This comprehensive review article comprises several case reports, case series, cohort studies, retrospective studies, and randomized clinical trials.
Psychosocial impact of Covid-19 outbreak on Italian asthmatic children and their mothers in a post lockdown scenario
Published: April 2021   Journal: Scientific Reports
Italy was the first European country to fight the Covid-19 outbreak. To limit the transmission of the virus, the Italian Government imposed strict domestic quarantine policies and temporary closure of non-essential businesses and schools from March 10th,2020. Although more and more literature is exploring the impact of the pandemic on non-referred children and families, only a few studies are focused on the psychosocial impact of Covid-19 in chronically ill children and their caregivers. The present study investigates asthma control and children and mothers’ psychological functioning (i.e.: psychological well-being, fear of contagion, and mothers’ Covid-19 related fears) in 45 asthmatic children aged 7-to-14, compared to a control sample. The subjects were administered an online survey after the lockdown (from 28th May to 23rd August 2020).
Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C

Hilary Whitworth; Sarah E. Sartain; Riten Kumar (et al.)

Published: April 2021   Journal: 75 Blood
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is associated with thrombotic complications in adults, but the incidence of COVID-19 related thrombosis in children and adolescents is unclear. Most children with acute COVID-19 have mild disease, but coagulopathy has been associated with multisystem inflammatory syndrome in children (MIS-C), a post-infectious complication. This study conducted a multicenter retrospective cohort research to determine the incidence of thrombosis in children hospitalized with COVID-19 or MIS-C and to evaluate associated risk factors.
Cite this research | Open access | Vol.: 137 | Issue: 18 | No. of pages: 22 | Language: English | Topics: Health | Tags: adolescent health, child health, child mortality, COVID-19, infectious disease, respiratory diseases
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UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.