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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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31 - 45 of 143
Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease

Setareh Mamishi; Babak Pourakbari; Mehrzad Mehdizadeh (et al.)

Published: April 2022   Journal: BMC Infectious Diseases

The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (COVID-19) is still rising. The aim of this study was to describe the epidemiological, clinical, laboratory, and imaging features of hospitalized patients with COVID-19 at an Iranian referral pediatrics hospital and to compare these parameters between hospitalized patients with and without severe disease, multisystem inflammatory syndrome in children (MIS-C) and children with acute COVID-19, as well as deceased and discharged cases. This study included hospitalized children and adolescents (≤ 18 years) with suspected COVID-19 who had positive results for SARS-CoV-2.

Factors affecting COVID-19 vaccine hesitancy in parents of children with cancer

Micah A. Skeens; Kylie Hill; Anna Olsavsky (et al.)

Published: April 2022   Journal: Pediatric Blood & Cancer

Little research exists on coronavirus (COVID-19) vaccine hesitancy among caregivers of children with cancer. We aimed to (a) describe vaccine hesitancy in parents of children with cancer for both their child and self, and (b) examine the mediating role of parent-reported COVID impact on the association between COVID exposure and vaccine hesitancy. This study conducted a national survey of parents of children with cancer via Facebook and Momcology, a pediatric cancer community-based organization recruited February–May 2021. Parents completed standardized measures online. A series of mediation models assessed the role of COVID-19 impact (e.g., effects on parenting and well-being) on associations between COVID-19 exposure (e.g., direct/indirect exposure) and vaccine hesitancy. Moderation models examined the role of treatment status, COVID-19 exposure, impact, and vaccine hesitancy.

Influence of SARS-CoV-2 pandemic on sleep habits in a pediatric population

Sara Completo; Andreia Fiúza Ribeiro; Ana Rute Manuel (et al.)

Published: April 2022   Journal: Sleep Science
This study aims to describe the health characteristics of rotating shift mining workers that may be related to a worse course scenario for COVID-19, according to literature data. It is a cross-sectional from three studies with 1478 shift workers. Social, demographic, clinical, and biochemical variables were analyzed. Risk factors for COVID-19 analyzed: hyperglycemia, altered blood pressure, dyslipidemia, hypovitaminosis D, obesity, presence of pre-existing cardiovascular diseases, and smokers.
Acute symptoms in SARS-CoV-2 positive adolescents aged 15–18 years – Results from a Danish national cross-sectional survey study

Selina Kikkenborg Berg; Pernille Palm; Susanne Dam Nielsen (et al.)

Published: April 2022   Journal: The Lancet Regional Health - Europe

The purpose of this study was to investigate prevalence of self-reported symptom burden during the acute phase of SARS-CoV-2 infection and associated factors including sex differences. All Danish adolescents aged 15–18 years with laboratory confirmed SARS-CoV-2 infection between January 2020 and July 2021 were invited to participate. A survey covered the initial four weeks of SARS-CoV-2 infection and included questions regarding 17 symptoms associated with acute COVID-19, symptom burden and medical history. Statistical analyses included descriptive statistics and logistic regression.

Cite this research | Open access | Vol.: 16 | No. of pages: 10 | Language: English | Topics: Health | Tags: adolescent health, COVID-19, infectious disease, pandemic, respiratory diseases | Countries: Denmark
Risk of SARS-CoV-2 reinfections in children: a prospective national surveillance study between January, 2020, and July, 2021, in England

Anna A. Mensah; Helen Campbell; Julia Stowe (et al.)

Published: March 2022   Journal: DOI:https://doi.org/10.1016/S2352-4642(22)00059-1

Reinfection after primary SARS-CoV-2 infection is uncommon in adults, but little is known about the risks, characteristics, severity, or outcomes of reinfection in children. This study aimed to assess the risk of SARS-CoV-2 reinfection in children and compare this with the risk in adults, by analysis of national testing data for England. National surveillance study to assess reinfection of SARS-CoV-2 in children in England  used national SARS-CoV-2 testing data to estimate the risk of reinfection at least 90 days after primary infection from Jan 27, 2020, to July, 31, 2021, which encompassed the alpha (B.1.1.7) and delta (B.1.617.2) variant waves in England. Data from children up to age 16 years who met the criteria for reinfection were included. Disease severity was assessed by linking reinfection cases to national hospital admission data, intensive care admission, and death registration datasets.

Sedentary time and fast-food Consumption Associated With Weight Gain During COVID-19 lockdown in children and adolescents with overweight or obesity

Sarah Woo; Heonil Yang; YoonMyung Kim (et al.)

Published: March 2022   Journal: Journal of Korean Medical Science

The coronavirus disease pandemic is predicted to have adverse health effects on children and adolescents who are overweight or obese due to restricted school activity and stay-at-home orders. The purpose of this observational study was to determine the factors associated with weight gain in children and adolescents with overweight and obesity during coronavirus disease 2019 (COVID-19) lockdown. Ninety-seven participants (sex- and age-specific body mass index (BMI) ≥ 85th percentile) were included. A baseline examination was conducted pre-COVID-19 (August 2019 to January 2020), and re-examination was performed post-lockdown (June to September 2020) and the results were compared. Correlation and regression analyses were conducted to investigate the association among changes in cardiometabolic markers and lifestyle behaviors with changes in BMI z-score.

COVID-19 vaccine hesitancy among low-income, racially and ethnically diverse US parents

Samantha Schilling; Colin J. Orr; Alan M. Delamater (et al.)

Published: March 2022   Journal: Patient Education and Counseling
This study aimed to examine factors impacting U.S. parents’ intention to vaccinate their children against COVID-19. Data were collected February-May 2021 from parents living in six geographically diverse locations. The COVID-19 Exposure and Family Impact Survey assessed perceived susceptibility and severity to adverse outcomes from the pandemic. Semi-structured interviews assessed perceptions about benefits and risks of vaccinating children..
COVID-19 vaccine hesitancy among adolescents: cross-ectional school survey in four Chinese cities prior to vaccine availability

Palizhati Rehati; Nubiya Amaerjiang; Liping Yang (et al.)

Published: March 2022   Journal: Vaccines
To address the novel coronavirus disease (COVID-19) pandemic, development and regulatory evaluations have been accelerated for vaccines, authorizing emergency use. To anticipate vaccine preparedness in adolescents, this study analyzed COVID-19 vaccination awareness and willingness to vaccinate before the vaccine became available. It conducted a cross-sectional survey among 9153 (4575 boys, 50%) students with a mean age of 14.2 years old in four cities in China to collect information on demographic characteristics and their COVID-19 vaccination concerns. Multinomial logistic regression was used to analyze the influencing factors of vaccine hesitancy (“not sure”) and resistance (“do not want it”).
Effectiveness and safety of SARS-CoV-2 vaccines among children and adolescents: a systematic review and meta-analysis

Peng Gao; Shan Cai; Qiao Liu (et al.)

Published: March 2022   Journal: Vaccines
The proportion of children and adolescents with COVID-19 had gradually increased according to data reported by WHO. However, there was no meta-analysis of effectiveness and safety of SARS-CoV-2 vaccines in children and adolescents. This paper aimed to provide investigationbased medical evidence and reference recommendations for children and adolescents in regard to SARS-CoV-2 vaccines. It systematically searched PubMed, Embase, and Web of Science from inception to 5 January 2022. RCTs and observational studies that examined the effectiveness and safety were included.
Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Anita Dileep; Sham ZainAlAbdin; Salah AbuRuz (et al.)

Published: February 2022   Journal: Scientific Reports
Pregnant women with COVID-19 require special attention and care, since the infection does not only affect the mother, but also her neonate and adversely affects pregnancy outcomes. The main goal of this retrospective cohort study is to investigate association between the maternal COVID-19 severity and risk of developing adverse neonatal outcomes. Patients were stratified into asymptomatic/mild and moderate to severe COVID-19. The following neonatal outcomes were assessed: gestational age at the time of delivery, birth weight, neonatal infection, neonatal intensive care unit (NICU) admission.
Socioeconomic disadvantages and vulnerability to the pandemic among children and youth: a macro-level investigation of American counties

Bocong Yuan; Xinting Huang; Jiannan Lic (et al.)

Published: February 2022   Journal: Children and Youth Services Review
This study intends to reveal the underlying structural inequity in vulnerability to infection of the novel coronavirus disease pandemic among children and youth. Using multi-source data from New York Times novel coronavirus disease tracking project and County Health Rankings & Roadmap Program, this study shows that children and youth in socioeconomically disadvantaged status are faced with disproportionate risk of infection in this pandemic. On the county level, socioeconomic disadvantages (i.e., single parent family, low birthweight, severe housing problems) contribute to the confirmed cases and death cases of the novel coronavirus disease. Policymakers should pay more attention to this vulnerable group to implement more targeted and effective epidemic prevention and control.
Association between risk perception and influenza vaccine hesitancy for children among reproductive women in China during the COVID-19 pandemic: a national online survey

Min Du; Liyuan Tao; Jue Liu (et al.)

Published: February 2022   Journal: BMC Public Health

In China, the national prevalence of parental influenza vaccine hesitancy (IVH) during the pandemic of coronavirus disease 2019 (COVID-19), and the association between risk perception and parental IVH are still unclear. This study aimed to explore the association between risk perception and IVH for children among reproductive women in China, a poorly studied area. From December 14, 2020, to January 31, 2021, we conducted a national anonymous online survey on IVH for children among reproductive women in China. We assessed risk perception including perceived susceptibility, severity, barriers, and benefits using the Health Belief Model and then classified each variable into three groups based on tertiles. Logistic regression models were used to calculate the adjusted odds ratio (aOR) of risk perception related to vaccine hesitancy after controlling for sociodemographic characteristics, health status, and knowledge of influenza, among other factors. Additionally, subgroup analysis was performed.

Infants hospitalized for acute COVID-19: disease severity in a multicenter cohort study

Joanna Merckx; Shaun K. Morris; Joan Robinson (et al.)

Published: February 2022   Journal: European Journal of Pediatrics
Age is the most important determinant of COVID-19 severity. Infectious disease severity by age is typically J-shaped, with infants and the elderly carrying a high burden of disease. This study reports on the comparative disease severity between infants and older children in a multicenter retrospective cohort study of children 0 to 17 years old admitted for acute COVID-19 from February 2020 through May 2021 in 17 pediatric hospitals. It compares clinical and laboratory characteristics and estimate the association between age group and disease severity using ordinal logistic regression.
Sanitary measures to contain COVID-19 spread decreased pediatric hospitalizations due to other respiratory infections in São Paulo, Brazil

Gabriela Marengone Altizani; Viviane da Mata Pasti Balbão; Gilberto Gambero Gaspar (et al.)

Published: February 2022   Journal: Jornal de Pediatria

After the Covid-19 pandemics hit Brazil and sanitary measures were adopted to contain its dissemination, pediatric hospital admissions were apparently fewer than usual. The authors aimed to describe the time trends of public hospital admissions of children and adolescents due to respiratory infections (RIs) in São Paulo State, Brazil, before and after the adoption of sanitary measures to contain the dissemination of Covid-19. Ecological, time-series study on the monthly average number of admissions per day of children and adolescents (< 16 years) admitted to public hospitals of São Paulo due to acute RIs between January 2008 and March 2021. Data from 2008 to 2019 were used to adjust the statistical model, while data from 2020 and 2021 were compared to the values predicted by the model.

Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study

Jeané Cloete; Annelet Kruger; Maureen Masha (et al.)

Published: February 2022   Journal: The Lancet Child & Adolescent Health

South Africa reported a notable increase in COVID-19 cases from mid-November, 2021, onwards, starting in Tshwane District, which coincided with the rapid community spread of the SARS-CoV-2 omicron (B.1.1.529) variant. This increased infection rate coincided with a rapid increase in paediatric COVID-19-associated admissions to hospital (hereafter referred to as hospitalisations). The Tshwane Maternal-Child COVID-19 study is a multicentre observational study which investigated the clinical manifestations and outcomes of paediatric patients (aged ≤19 years) who had tested positive for SARS-CoV-2 and were admitted to hospital for any reason in Tshwane District during a 6-week period at the beginning of the fourth wave of the COVID-19 epidemic in South Africa. It used five data sources, which were: (1) COVID-19 line lists; (2) collated SARS-CoV-2 testing data; (3) SARS-CoV-2 genomic sequencing data; (4) COVID-19 hospitalisation surveillance; and (5) clinical data of public sector COVID-19-associated hospitalisations among children aged 13 years and younger.

31 - 45 of 143

UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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