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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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31 - 45 of 280
Safety, immunogenicity, and efficacy of COVID-19 vaccines in adolescents, children, and infants: a systematic review and meta-analysis

Yuxuan Du; Long Chen; Yuan Shi

Published: April 2022   Journal: Frontiers in Public Health

As the epidemic progresses, universal vaccination against COVID-19 has been the trend, but there are still some doubts about the efficacy and safety of COVID-19 vaccines in adolescents, children, and even infants. This study aims to evaluate the safety, immunogenicity, and efficacy of COVID-19 vaccines in the population aged 0–17 years. A comprehensive search for relevant randomized controlled trials (RCTs) was conducted in PubMed, Embase, and the Cochrane Library from inception to November 9, 2021. All data were pooled by RevMan 5.3 statistical software, with risk ratio (RR) and its 95% confidence interval as the effect measure. This study protocol was registered on PROSPERO (CRD42021290205).

Caregivers' attitudes toward COVID-19 vaccination in children and adolescents with a history of SARS-CoV-2 infection

Danilo Buonsenso; Piero Valentini; Marina Macchi (et al.)

Published: April 2022   Journal: Frontiers in Pediatrics

Limited data are available on the attitudes of caregivers toward COVID-19 vaccination in children and adolescents with a history of SARS-CoV-2 infection or Long Covid symptoms. The aim of this study was to investigate the vaccine hesitancy among caregivers of children and adolescents with a documented history of SARS-CoV-2 infection and to explore the possible associations between COVID-19 manifestations and the acceptance of the vaccine. Caregivers of children or adolescents with a microbiologically confirmed diagnosis of SARS-CoV-2 infection evaluated in two University Hospitals were interviewed.

Willingness toward COVID-19 vaccination, coadministration with other vaccines and receive a COVID-19 vaccine booster: a cross-sectional study on the guardians of children in China

Libing Ma; Jin Yang; Ting Zhang (et al.)

Published: April 2022   Journal: Human Vaccines & Immunotherapeutics
This study aimed to investigate the changes in the willingness of guardians to administer the COVID-19 vaccine to their children, allow the coadministration of other vaccines, and administer the COVID-19 vaccine booster dose. This was a follow-up study conducted 6 months after a similar previous study. The self-administered questionnaire was distributed through the “Xiao Dou Miao” app and 9424 guardians with access to this app participated in the survey that was conducted from September 15 to October 8, 2021. Of all the participating guardians, 86.68% were willing to vaccinate their children with the COVID-19 vaccine, which was approximately 16% more than those in our previous study. Guardians aged ≥40 years, healthcare workers, and those with children aged ≥3 years were more willing to vaccinate their children. Approximately 77% of the guardians were willing toward the coadministration of COVID-19 and influenza vaccines. Approximately 64% of the guardians were willing toward the coadministration of other nonimmunization program vaccines with the COVID-19 vaccine for their children.
Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study

Helene Kildegaard; Lars Christian Lund; Mikkel Højlund

Published: April 2022   Journal: BMJ
This study aims to assess the risk of acute and post-acute adverse events after SARS-CoV-2 infection in children and adolescents in Denmark and to evaluate the real world effectiveness of the BNT162b2 mRNA vaccine (Pfizer-BioNTech) among adolescents.
Awareness of Covid-19 and attitudes toward vaccination in parents of children between 0 and 18 years: a cross-sectional study

Elif Bilsin Kocamaz; Halil Kocamaz

Published: April 2022   Journal: Journal of pediatric nursing

Many countries are struggling with the covid-19 pandemic. Although many measures have been adopted to reduce the transmission of the virus, vaccination is the only solution for controlling and ending the pandemic. The purpose of this study is to evaluate the awareness of covid-19 and attitudes toward covid-19 vaccination in parents. The research is a descriptive and cross-sectional study. The online survey was conducted. The population of the study consisted of parents of children aged 0-18 who agreed to participate through the social media (Facebook and Instagram) between May 26 and July 7, 2021. With the community research model, the minimum sample size was determined as 384. A parent description form and the Coronavirus (Covid-19) Awareness Scale (CAS) were used for data collection.

Current status of COVID-19 vaccination: safety and liability concern for children, pregnant and lactating women

Swagat Kumar Das; Manish Paul; Bikash Chandra Behera (et al.)

Published: April 2022   Journal: Expert Review of Vaccines

Since its inception, Coronavirus disease-19 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has claimed a significant number of lives around the world. COVID-19 vaccine development involves several vaccine platforms, including traditional live-attenuated or killed viral particles, viral vectors or DNA, and mRNA-based vaccines. The efficacy and effectiveness (EV) of these vaccines must be assessed in order to determine the extent to which they can protect us against infection. Despite the fact that some affluent countries attempted to vaccinate the majority of their inhabitants, children and pregnant women were first excluded.

Factors affecting COVID-19 vaccine hesitancy in parents of children with cancer

Micah A. Skeens; Kylie Hill; Anna Olsavsky (et al.)

Published: April 2022   Journal: Pediatric Blood & Cancer

Little research exists on coronavirus (COVID-19) vaccine hesitancy among caregivers of children with cancer. We aimed to (a) describe vaccine hesitancy in parents of children with cancer for both their child and self, and (b) examine the mediating role of parent-reported COVID impact on the association between COVID exposure and vaccine hesitancy. This study conducted a national survey of parents of children with cancer via Facebook and Momcology, a pediatric cancer community-based organization recruited February–May 2021. Parents completed standardized measures online. A series of mediation models assessed the role of COVID-19 impact (e.g., effects on parenting and well-being) on associations between COVID-19 exposure (e.g., direct/indirect exposure) and vaccine hesitancy. Moderation models examined the role of treatment status, COVID-19 exposure, impact, and vaccine hesitancy.

Parental vaccine hesitancy and concerns regarding the COVID-19 virus

Teresa L. Salazar; Deborah L. Pollard; Deborah M. Pina-Thomas (et al.)

Published: April 2022   Journal: Journal of Pediatric Nursing
This study assessed parental vaccine hesitancy in a metropolitan area of the United States. The study aimed to determine what characteristics and contributing factors influenced parental vaccine hesitancy and concerns regarding COVID-19. An online survey was used to recruit 93 parents to answer demographic and vaccine hesitancy information. Vaccine hesitancy was measured using the Parent Attitudes about Childhood Vaccines survey. The study was conducted between June 2020 and September 2020 during the COVID-19 pandemic.
Survey data on the attitudes of adolescents in Hong Kong towards the COVID-19 vaccination

Wilfred Hing-Sang Wong; Daniel Leung; Gilbert T. Chua (et al.)

Published: April 2022   Journal: Data in Brief
This article presents a novel data set on Hong Kong's adolescents’ attitude towards the COVID-19 vaccination, excluding their parental opinions. This research used a cross-sectional questionnaire survey, which collects data from the population at a single point in time. Our questionnaire was designed in both English and Chinese for the adolescents’ convenience, using a self-designed, online questionnaire website, which was sent to 30 secondary schools across Hong Kong at the beginning of June 2021, to be completed by 31st June 2021.
Factors that differentiate COVID-19 vaccine intentions among Indiana parents: implications for targeted vaccine promotion

Katharine J. Head; Gregory D. Zimet; Constantin T. Yiannoutsos (et al.)

Published: April 2022   Journal: Preventive Medicine
Given low rates of uptake of the COVID-19 vaccine for children 12–17 and 5–11 years old, research is needed to understand parental behaviors and behavioral intentions related to COVID-19 vaccination for their children. In the state of Indiana, this study conducted a non-random, online survey of parents or caregivers (N = 10,266) about their COVID-19 vaccine intentions or behaviors, demographic characteristics, and potential motivating reasons for getting the vaccine.
Why do Hong Kong parents have low intention to vaccinate their children against COVID-19? testing health belief model and theory of planned behavior in a large-scale survey

Jian-Bin Li; Eva Yi Hung Lau; Derwin King Chung Chan

Published: April 2022   Journal: Vaccine
COVID-19 vaccines have been authorized for use in children in some societies. Parents’ intention to vaccinate their children is context-specific. Drawing upon health belief model (HBM) and theory of planned behavior (TPB), this study contributed to a timely topic by examining the extent to which parents intended to vaccinate their children and its associated factors in Hong Kong, where the government announced children as young as five could take COVID-19 vaccines starting from 21 January 2022. A large-scale, online survey was conducted among 11,141 Hong Kong parents (86% mothers) of children aged 5–12 (N = 14,468, 49.5% girls).
Home vsitors and community health workers COVID-19 vaccination messaging guide

Tom Davis; Micah Branaman

Institution: World Vision
Published: March 2022

The fight against COVID-19 and new variants is not over. Vaccines have demonstrated an incredible effectiveness at preventing serious COVID-19 disease. The best way now to protect and build on the progress made so far is to help as many people as possible around the world to get COVID-19 vaccinations while ensuring an ability to act quickly in response to any future developments of the pandemic. This will be critical not only to protect the children and families we serve, but also to protect the entire world against continuing waves of virus variants. Building skills in the promotion of vaccines can also help us to prepare for the next pandemic.

Assessing the transition of COVID-19 burden towards the young population while vaccines are rolled out in China

Jun Cai; Juan Yang; Xiaowei Deng (et al.)

Published: March 2022   Journal: Emerging Microbes & Infections
SARS-CoV-2 infection causes most cases of severe illness and fatality in older age groups. Over 92% of the Chinese population aged ≥12 years has been fully vaccinated against COVID-19 (albeit with vaccines developed against historical lineages). At the end of October 2021, the vaccination programme has been extended to children aged 3–11 years. This study aimed to assess whether, in this vaccination landscape, the importation of Delta variant infections could shift COVID-19 burden from adults to children. It developed an age-structured susceptible-infectious-removed model of SARS-CoV-2 transmission to simulate epidemics triggered by the importation of Delta variant infections and project the age-specific incidence of SARS-CoV-2 infections, cases, hospitalizations, intensive care unit admissions, and deaths.
The cross-sectional survey on COVID-19 vaccine hesitancy and it predictors among Chinese parents of 3–17 years aged children in Shenzhen City

Ting Li; Xichenhui Qiu; Xue Gong (et al.)

Published: March 2022   Journal: Annals of Agricultural and Environmental Medicine
Vaccinations programs on 3–17 years aged children in China have been launched in some cities since July 2021; and comparative evaluations are important to push the programs forward. Therefore, this study is conducted to explore the COVID-19 vaccine hesitancy and it predictors among Chinese parents of 3–17 years aged children; and their willingness to vaccinate their child/children. A cross-sectional study was conducted based on the online survey; and 3484 participants were recruited in health centers of Shenzhen, China.
Parents’ attitudes, knowledge and practice towards vaccinating their children against COVID-19: a cross-sectional study

Walid Al-Qerem; Abdel Qader Al Bawab; Alaa Hammad (et al.)

Published: March 2022   Journal: Human Vaccines & Immunotherapeutics
The question of whether children should be vaccinated against COVID-19 is currently being argued. The risk-benefit analysis of the vaccine in children has been more challenging because of the low prevalence of acute COVID-19 in children and the lack of confidence in the relative effects of the vaccine and the disease. One of the most convincing arguments for vaccinating healthy children is to protect them from long-term consequences. The aim of this study was to assess Jordanian parents’ intention to vaccinate their children. This is an Internet-based cross-sectional survey. The researchers prepared a Google Forms survey and shared the link with a number of Jordanian Facebook generic groups. Data were gathered between September and November 2021. In this study, convenience sampling was used. Knowledge about COVID-19 and preventive practices against COVID-19 were calculated for each participant. A total of 819 participants completed the survey (female = 70.9%).
31 - 45 of 280

UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.