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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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661 - 675 of 1129
Children and SARS-CoV-2

AUTHOR(S)
Dusan Bogunovic; Miriam Merad

Published: July 2021   Journal: Cell Host & Microbe
A previously immune-naive world population is experiencing natural infection with SARS-CoV-2. Severe COVID-19 predominantly impacts adults, yet multisystem inflammatory disorder primarily impacts children. Herein, this article discusses known clinical and biological features of SARS-CoV-2 in children and reflects on currently identified immune features and discusses what remains unknown.
Cite this research | Open access | Vol.: 29 | Issue: 7 | No. of pages: 1040-1042 | Language: English | Topics: Health | Tags: child health, COVID-19, disease transmission, infectious disease, medical research, respiratory diseases
Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study

AUTHOR(S)
Stephen T. J. Ray; Omar Abdel-Mannan; Mario Sa (et al.)

Published: July 2021   Journal: The Lancet Child & Adolescent Health
The spectrum of neurological and psychiatric complications associated with paediatric SARS-CoV-2 infection is poorly understood. This study aimed to analyse the range and prevalence of these complications in hospitalised children and adolescents. It did a prospective national cohort study in the UK using an online network of secure rapid-response notification portals established by the CoroNerve study group. Paediatric neurologists were invited to notify any children and adolescents (age <18 years) admitted to hospital with neurological or psychiatric disorders in whom they considered SARS-CoV-2 infection to be relevant to the presentation. Patients were excluded if they did not have a neurological consultation or neurological investigations or both, or did not meet the definition for confirmed SARS-CoV-2 infection (a positive PCR of respiratory or spinal fluid samples, serology for anti-SARS-CoV-2 IgG, or both), or the Royal College of Paediatrics and Child Health criteria for paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Individuals were classified as having either a primary neurological disorder associated with COVID-19 (COVID-19 neurology group) or PIMS-TS with neurological features (PIMS-TS neurology group). The denominator of all hospitalised children and adolescents with COVID-19 was collated from National Health Service England data.
Prevalence and determinants of symptomatic COVID-19 infection among children and adolescents in Qatar: a cross sectional analysis of 11445 individuals

AUTHOR(S)
Omran A. H. Musa; Tawanda Chivese; Devendra Bansa (et al.)

Published: July 2021   Journal: Epidemiology and Infection
There is a paucity of evidence about the prevalence and risk factors for symptomatic infection among children. This study aimed to describe the prevalence of symptomatic COVID-19 and its risk factors in children and adolescents aged 0-18 years in Qatar.
Short-term outcome of pregnant women vaccinated by BNT162b2 mRNA COVID-19 vaccine

AUTHOR(S)
S. Bookstein Peretz; N. Regev; L. Novick (et al.)

Published: July 2021   Journal: Ultrasound in Obstetrics & Gynecology

This study aims to determine the immunogenicity and reactogenicity of Pfizer's BNT162b2 COVID-19 vaccine among pregnant women compared with non-pregnant women, and to evaluate the obstetric outcome following vaccination. An observational case-control study of pregnant women, who were vaccinated by a 2-dose regimen of BNT162b2 vaccine during gestation between January-February 2021 (study group) and were compared to age-matched non-pregnant women who received the vaccine during the same time period (control group).

Early influenza vaccination rates decline in children during the COVID-19 pandemic

AUTHOR(S)
Benjamin Fogel; Eric W. Schaefer; Steven D. Hicks

Published: July 2021   Journal: Vaccine

This investigation sought to determine whether early season rates of pediatric influenza vaccination changed in a season when there was a concurrent COVID-19 pandemic. This study used cohort and cross sectional data from an academic primary care division in Southcentral Pennsylvania that serves approximately 17,500 patients across 4 practice sites. Early season (prior to November 1) vaccination rates in 2018, 2019 and 2020 were recorded for children, age 6 months to 17 years.

Cite this research | Open access | Vol.: 39 | Issue: 31 | No. of pages: 4291-4295 | Language: English | Topics: Health | Tags: child health, child immunization, COVID-19, vaccination, vaccination policies | Countries: United States
Should older adult pneumococcal vaccination recommendations change due to decreased vaccination in children during the pandemic? A cost-effectiveness analysis

AUTHOR(S)
Kenneth J. Smith; Angela R. Wateska; Mary Patricia Nowalk (et al.)

Published: July 2021   Journal: Vaccine
The COVID-19 pandemic is causing declines in childhood immunization rates. This study examined potential COVID-19-related changes in pediatric 13-valent pneumococcal conjugate vaccine (PCV13) use, subsequent impact on childhood and adult pneumococcal disease rates, and how those changes might affect the favorability of PCV13 use in non-immunocompromised adults aged ≥65 years.
Cite this research | Open access | Vol.: 39 | Issue: 31 | No. of pages: 4278-4282 | Language: English | Topics: Health | Tags: child health, COVID-19, disease transmission, immunization, infectious disease, vaccination, vaccination policies
Intentions of public school teachers in British Columbia, Canada to receive a COVID-19 vaccine

AUTHOR(S)
C. Sarai Racey; Robine Donken; Imogen Porter (et al.)

Published: July 2021   Journal: Vaccine X
To control the COVID-19 pandemic high vaccine acceptability and uptake will be needed. Teachers represent a priority population to minimize social disruption and ensure continuity in education, which is vital for the well-being and healthy development of youth during the pandemic. The objective of this analysis was to measure public school teachers’ intentions to receive a COVID-19 vaccine in British Columbia (BC), Canada.
Cite this research | Open access | No. of pages: 7 | Language: English | Topics: Health | Tags: COVID-19, infectious disease, teachers, vaccination, vaccination policies | Countries: Canada
Parents’ intentions to vaccinate their children against COVID-19

AUTHOR(S)
Kristine M. Ruggiero; John Wong; Casey Fryer Sweeney (et al.)

Published: July 2021   Journal: Journal of Pediatric Health Care

With the COVID-19 vaccine rollout is well underway now beginning in children ages 12 and over, it is unknown what percent of parents plan to vaccinate their children against COVID-19. The purpose of this descriptive correlational study was to examine parents’ attitudes, beliefs, and behaviors in administering a COVID-19 vaccine.

Association between race and COVID-19 outcomes among 2.6 million children in England

AUTHOR(S)
Defne Saatci; Tom A. Ranger; Cesar Garriga (et al.)

Published: June 2021   Journal: JAMA Pediatrics

Although children mainly experience mild COVID-19 disease, hospitalization rates are increasing, with limited understanding of underlying factors. There is an established association between race and severe COVID-19 outcomes in adults in England; however, whether a similar association exists in children is unclear. This article aims to investigate the association between race and childhood COVID-19 testing and hospital outcomes.

Continuing learning for the most vulnerable during COVID-19: Lessons from Let Us Learn in Afghanistan, Bangladesh, Liberia, Madagascar and Nepal

AUTHOR(S)
Cirenia Chávez; Marco Valenza; Annika Rigole; Thomas Dreesen

The COVID-19 pandemic has disrupted every aspect of society. In mid-April 2020, 192 countries had closed their schools, putting 9 out of 10 enrolled children out of school.

These closures disproportionately affected marginalized children, worsening existing inequities across education systems worldwide.

This brief draws on the experience of five UNICEF education country programmes supported by the Let Us Learn (LUL) initiative, to document tangible lessons in adapting education programmes to support the most marginalized children during school and learning centre closures.

The evidence in this brief stems from a series of semi-structured interviews with Education and Child Protection specialists, as well as a document review of available COVID-19 response studies, in the five LUL-supported UNICEF Country Offices.

Rapid Review Protocol - Life in Lockdown: Child and adolescent mental health and well-being in the time of COVID-19

While there has been a global rush to generate rapid evidence on COVID-19 mental health impacts among adults, limited evidence exists on the potential impacts on children.

This is the protocol for our rapid review that seeks to (i) understand the immediate impact of COVID-19’s first wave on the mental health of children and adolescents (0–19 years); and (ii) apply lessons learned from this pandemic to mitigate the impacts of future health crises.

The key research questions of this review are: 

  • What has been the immediate impact of COVID-19 and associated containment measures on the mental health and psychosocial well-being of children and adolescents?
  • How and which risk and protective factors have affected mental health during COVID-19 and have they varied across subgroups of children and adolescents?

Children and COVID-19 vaccines

AUTHOR(S)
Lindsay A. Thompson; Sonja A. Rasmussen

Published: June 2021   Journal: JAMA Pediatrics

Nearly 4 million children in the US have been infected with COVID-19 as of May 2021. While most children have had mild or no symptoms, thousands have been hospitalized and several hundred have died. Children with underlying conditions are more likely to experience severe effects of COVID-19, but even healthy children can be severely affected. Children can spread COVID-19 to others and also can have long-term effects that last months. For these reasons, children need to be protected from COVID-19. Currently, 3 vaccines are authorized for adults in the United States. In studies of tens of thousands of people, these vaccines were safe and effective. The vaccine made by Pfizer was recently authorized for children 12 years and older. Two doses of this vaccine are recommended to be given 3 weeks apart. The other 2 vaccines were authorized for persons 18 years and older but are expected to be available for teenagers soon. Studies in younger children as young as age 6 months are ongoing and if these studies show that they are safe and effective, vaccines could be available for children 6 months and older by late 2021 or early 2022.

 

ISIDOG consensus guidelines on COVID-19 vaccination for women before, during and after pregnancy

AUTHOR(S)
Gilbert G. G. Donders; Svitrigaile Grinceviciene; Kai Haldre (et al.)

Published: June 2021   Journal: Journal of Clinical Medicine
Sars-CoV-2 infection poses particular problems in pregnancy, as the infection more frequently causes severe complications than in unaffected pregnant women or nonpregnant women with SARS-CoV-2 infection. Now that vaccination is available and rapidly being implemented worldwide, the question arises whether pregnant women should be vaccinated, and if so, whether they should receive priority. Available scientific data and available guidelines about vaccination against SARS-CoV-2 were collected by the Guideline Committee of the International Society of Infectious Diseases in Obstetrics and Gynecology (ISIDOG) and were analyzed, discussed and summarized as guidelines for healthcare workers caring for pregnant women. Concluding statements were graded according to the Oxford evidence-based medicine grading system.
Determinant of intention to receive COVID-19 vaccine among school teachers in Gondar City, Northwest Ethiopia

AUTHOR(S)
Simegnew Handebo; Maereg Wolde; Kegnie Shitu

Published: June 2021   Journal: Plos One

Scientists across the world are working on innovating a successful vaccine that will save lives and end COVID-19 pandemic. World Health Organization (WHO) is working to make sure COVID-19 vaccines can be safely delivered to all those who need them. Indeed, the successful deployment and a sufficient uptake of vaccines is equally important. Acceptance and accessibility of such vaccine is a key indicator of vaccination coverage. This study aimed to assess the determinants of intention to receive COVID-19 vaccine among school teachers in Gondar City.

Parental acceptability of COVID-19 vaccination for children under the age of 18 years among Chinese doctors and nurses: a cross-sectional online survey

AUTHOR(S)
Zixin Wang; Rui She; Xi Chen (et al.)

Published: June 2021   Journal: Human Vaccines & Immunotherapeutics
This study investigated parental acceptability of COVID-19 vaccination for children under the age of 18 years among Chinese parents who are healthcare workers. A closed online survey among full-time doctors or nurses employed by the five collaborative hospitals who had access to smartphones was conducted. Facilitated by the hospital administrators, prospective participants received an invitation sent by the research team via the existing WeChat/QQ groups to complete an online questionnaire. A total of 2,281 participants completed the survey. This study was a sub-analysis of 1332 participants who had at least one child under the age of 18 years. Among the participants, 44.5% reported that they would likely or very likely to have their children under the age of 18 years take up COVID-19 vaccination in the next six months.
661 - 675 of 1129

UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.

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Check our quarterly thematic digests on children and COVID-19

Each quarterly thematic digest features the latest evidence drawn from the Children and COVID-19 Research Library on a particular topic of interest.
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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.