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Alexander Joachim; Felix Dewald; Isabelle Suárez (et al.)
The extent to which children and adolescents contribute to SARS-CoV-2 transmission remains not fully understood. Novel high-capacity testing methods may provide real-time epidemiological data in educational settings helping to establish a rational approach to prevent and minimize SARS-CoV-2 transmission. This study investigated whether pooling of samples for SARS-CoV-2 detection by RT-qPCR is a sensitive and feasible high-capacity diagnostic strategy for surveillance of SARS-CoV-2 infections in schools. In this study, students and school staff of 14 educational facilities in Germany were tested sequentially between November 9 and December 23, 2020, two or three times per week for at least three consecutive weeks. Participants were randomized for evaluation of two different age adjusted swab sampling methods (oropharyngeal swabs or buccal swabs compared to saliva swabs using a ‘lolli method’).
Lei Chang; Yuan Yuan Liu; Hui Jing Lu (et al.)
Lisa J. Meltzer; Jared M. Saletin; Sarah M. Honaker (et al.)
This study aims to examine associations among instructional approaches, school start times, and sleep during the COVID-19 pandemic in a large, nationwide sample of U.S. adolescents. Cross-sectional, anonymous self-report survey study of a community-dwelling sample of adolescents (grades 6–12), recruited through social media outlets in October/November 2020. Participants reported on instructional approach (in-person, online/synchronous, online/asynchronous) for each weekday (past week), school start times (in-person or online/synchronous days), and bedtimes (BT) and wake times (WT) for each identified school type and weekends/no school days. Sleep opportunity was calculated as BT-to-WT interval. Night-to-night sleep variability was calculated with mean square successive differences.
Kaitlyn Howden; Camille Glidden; Razvan G. Romanescu (et al.)
Lise Boey; Mathieu Roelants; Joanna Merckx (et al.)
Tommy Y. Kim; Esther C. Kim; Adrian Z. Agudelo (et al.)
There are limited studies with varying results evaluating the rate of hospitalizations of pediatric patients tested for COVID-19 in the United States. More information in the pediatric COVID-19 literature is needed. The objective of this study was to describe the rates of positive tests, hospitalization, severe disease, and mortality for COVID-19 in children. This study performed a retrospective analysis of data collected from a data warehouse from 184 hospitals across the United States. All cases of pediatric patients who were tested for COVID-19 were analyzed for test positivity, hospitalization, severe disease, and mortality. A separate subgroup analysis for ages < 1 year, 1–4 years, 5–8 years, 9–14 years, and 15–17 years was performed.
Sheena Mukkada; Nickhill Bhakta; Guillermo L. Chantada (et al.)
Previous studies have shown that children and adolescents with COVID-19 generally have mild disease. Children and adolescents with cancer, however, can have severe disease when infected with respiratory viruses. In this study, we aimed to understand the clinical course and outcomes of SARS-CoV-2 infection in children and adolescents with cancer. We did a cohort study with data from 131 institutions in 45 countries. We created the Global Registry of COVID-19 in Childhood Cancer to capture de-identified data pertaining to laboratory-confirmed SARS-CoV-2 infections in children and adolescents (<19 years) with cancer or having received a haematopoietic stem-cell transplantation. There were no centre-specific exclusion criteria. The registry was disseminated through professional networks through email and conferences and health-care providers were invited to submit all qualifying cases. Data for demographics, oncological diagnosis, clinical course, and cancer therapy details were collected.
Bassam Abu Hamad; Sarah Baird; Nicola Jones (et al.)
The population of Jordan has increased rapidly over the past 10 years, with the country taking in more than a million Syrian refugees, of whom nearly half are below the age of 18 years. The Government of Jordan, supported by the international community, has made substantial efforts to provide basic services for its refugees, but the COVID-19 pandemic has put additional pressure on the country’s limited resources. Given that young people account for a relatively large proportion of the population, especially the refugee population, it is critical that we understand what impacts the pandemic is having on adolescent girls and boys in order to ensure that the national response by government, nongovernmental organizations (NGOs) and development partners including the United Nations (UN) are adolescent-friendly and equitable. This research brief draws on the findings of a questionnaire-based telephone survey involving nearly 3000 adolescent boys and girls, conducted as part of the Region-wide Gender and Adolescence: Global Evidence (GAGE) longitudinal research programme which is co-funded by the United Kingdom’s Foreign, Commonwealth & Development Office (FCDO) and the World Health Organization (WHO) Regional Office for the Eastern Mediterranean.
As elsewhere, in the State of Palestine, the burden of COVID-19 morbidity and mortality has overwhelmingly fallen on older people. There is, however, growing recognition that younger people, including adolescents aged 10–19 years who account for more than a fifth of the population (1), are also suffering negative impacts on their health because of the COVID-19 pandemic. Given that nearly 40% of the population in the State of Palestine are refugees it is important to distinguish between the experiences of the non-refugee and the refugee adolescent populations, and within the latter, those living in camp and non-camp settings. Such disaggregated evidence will help to inform national response plans by government and development partners to ensure that they are both adolescent-responsive and equitable. This policy brief draws on findings of a questionnaire-based telephone survey involving just over 1000 adolescent boys and girls which was conducted as part of the Gender and Adolescence: Global Evidence (GAGE) longitudinal research programme.
Daniel Munblit; Louise Sigfrid; John O. Warner
Increasing numbers of people with prolonged symptoms after recovery from COVID-19 infection (long COVID) have been reported, prompting calls for research. Symptoms of long COVID are poorly characterized, with several phenotypes described, and the causes, treatments, and outcomes are unknown. Calls for research fail to address long COVID in children and adolescents. Given the demand for appropriate care for patients with this condition, agencies have published guidelines on treatment. However, these guidelines inappropriately combine research requirements and services for the children and older adults. The long-term consequences of COVID-19 remain unknown, but prolonged symptom duration and disability are commonly reported among adults. National Institute for Health and Care Excellence guidelines classify infection sequalae by the duration of symptoms, providing interim definitions for long COVID based on limited evidence from small cohorts with short-term follow-up of adults. The paucity of high-quality studies is a barrier to a comprehensive definition of long COVID and postacute COVID. This definition and harmonization of research, diagnosis, and treatment of individuals with long COVID could allow for cohesive national and international data collection and better estimation of incidence, prevalence, and risk factors that are tailored to different age groups.
Brianne R. Coulombe; Tuppett M. Yates
Daniel Jamieson; Lee Kannis-Dymand; Denise A. Beaudequin (et al.)
Marco Solmi; Samuele Cortese; Christoph U. Correll
Thomas Radtke; Agne Ulyte; Milo A. Puhan; Milo A. Puhan (et al.)
Children can experience SARS-CoV-2 postviral syndromes, but it is unclear to what extent these individuals are affected by long COVID. Evidence is predominantly limited to select populations without control groups,1-4 which does not allow estimating the overall prevalence and burden in a general pediatric population. This study compared symptoms compatible with long COVID in children and adolescents (hereafter “children”) reported within 6 months after SARS-CoV-2 serologic testing. Ciao Corona is a longitudinal cohort study investigating SARS-CoV-2 seroprevalence in 55 randomly selected schools in the canton of Zurich in Switzerland,5,6 which has a linguistically and ethnically diverse population of 1.5 million residents in urban and rural settings. Schools were selected randomly from the 12 cantonal districts, with number of schools proportional to population size. In Switzerland, children attended schools in person (with protective measures) in 2020-2021, except during a 6-week nationwide lockdown (March 16 to May 10, 2020).
UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.
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COVID-19 & Children: Rapid Research Response