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Children and COVID-19 Research Library

UNDER DEVELOPMENT UNICEF Innocenti's curated library of COVID-19 + Children research

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16 - 30 of 352
Reduced inflammatory responses to SARS-CoV-2 infection in children presenting to hospital with COVID-19 in China

AUTHOR(S)
Guoqing Qian; Yong Zhang; Yang Xu (et al.)

Published: April 2021   Journal: EClinical Medicine
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children is associated with better outcomes than in adults. The inflammatory response to COVID-19 infection in children remains poorly characterised. This study retrospectively analysed the medical records of 127 laboratory-confirmed COVID-19 patients aged 1 month to 16 years from Wuhan and Jingzhou of Hubei Province. Patients presented between January 25th and March 24th 2020. Information on clinical features, laboratory results, plasma cytokines/chemokines and lymphocyte subsets were analysed.
Cite this research | Open access | No. of pages: 7 | Language: English | Topics: Health | Tags: child health, COVID-19, infectious disease, respiratory diseases | Countries: China
Sub-Saharan Africa: growing up in crisis in a world of opportunities: the lasting impact of Covid-19 on children
Institution: *UNICEF
Published: April 2021

The COVID-19 pandemic has had a profound effect on the world’s population. Although it has been established that children are at lower risk of falling seriously ill with COVID-19, the pandemic has had, and continues to have, far-reaching effects on them. The pandemic poses a health crisis that has become a child rights’ crisis. It is heightening the impact of conflict and climate change on children. In sub-Saharan Africa, COVID-19 is exacerbating not only existing threats to the future that 550 million children face, but also measures put in place to control and contain the disease. While the arrival of the first vaccines brings hope to put an end to the pandemic, it will take time before these vaccines can reach everyone who needs them. This report sheds light on the various ways children in sub-Saharan Africa have been affected by the ongoing pandemic and how UNICEF and partners have been supporting them. The report also is a call to action to governments and the international community to take concerted action to mitigate the effects of the COVID-19 pandemic and associated control measures, and build forward a better world fit for children.

Post-COVID-19 pediatric inflammatory multisystem syndrome: association of ethnicity, key worker and socioeconomic status with risk and severity

AUTHOR(S)
Jonathan Broad; Julia Forman; James Brighouse (et al.)

Published: April 2021   Journal: Archives of Disease in Childhood
Patients from ethnic minority groups and key workers are over-represented among adults hospitalised or dying from COVID-19. In this population based retrospective cohort, we describe the association of ethnicity, socioeconomic and family key worker status with incidence and severity of Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARSCoV-2 (PIMS-TS).
Changes in children’s surgical services during the COVID-19 pandemic at a tertiary-level government hospital in a lower middle-income country

AUTHOR(S)
Md. Abdullah Al Farooq; S M Humayun Kabir; Tanvir Kabir Chowdhury (et al.)

Published: March 2021   Journal: BMJ Paediatrics Open
The aim of this study was to quantify the changes that occurred in the surgical services of children during the COVID-19 pandemic from the perspective of a low/middle-income country. Design A case–control study was conducted at a large referral centre in Bangladesh among patients aged ≤12 years. Comparisons were made between cases admitted during a period of ‘April to September 2020’ (Pandemic period) and controls during a similar period in 2019 (Reference period). The number of admissions and outpatient department (OPD) attendances, age and sex distribution, diagnosis, number and types of surgeries performed (elective vs emergency), variations in treatment of acute appendicitis, types of anaesthesia and mortality were compared
Cite this research | Open access | Vol.: 5 | Issue: 1 | No. of pages: 6 | Language: English | Topics: Health | Tags: child care services, child health, COVID-19 response, hospitalization, low-income countries | Countries: Bangladesh
Lifestyle changes and determinants of children’s and adolescents’ body weight increase during the first COVID-19 lockdown in Greece: the COV-EAT study

AUTHOR(S)
Odysseas Androutsos; Maria Perperidi; Christos Georgiou; Christos Georgiou (et al.)

Published: March 2021   Journal: Nutrients
Previous studies showed that the coronavirus disease 2019 (COVID-19) lockdown imposed changes in adults’ lifestyle behaviors; however, there is limited information regarding the effects on youth. The COV-EAT study aimed to report changes in children’s and adolescents’ lifestyle habits during the first COVID-19 lockdown and explore potential associations between changes of participants’ lifestyle behaviors and body weight. An online survey among 397 children/adolescents and their parents across 63 municipalities in Greece was conducted in April–May 2020. Parents self-reported changes of their children’s lifestyle habits and body weight, as well as sociodemographic data of their family.
Digestive system symptoms and function in children with COVID-19

AUTHOR(S)
Jiajia Wang; Xiaofeng Yuan

Published: March 2021   Journal: Medicine
The prevalence of children exhibiting coronavirus disease 2019 (COVID-19) with digestive system involvement remains unknown. Therefore, this study aimed to quantify the impact of COVID-19 on the digestive system of children. This meta-analysis searched PubMed, Embase, and Web of Science from January 1, 2020, to June 31, 2020. It also searched for COVID-19 publications in specific journals for more comprehensive results. It included studies that reported the epidemiological and clinical characteristics of COVID-19, and it excluded duplicate publications, reviews, animal studies, case reports, publications without the full text, studies with incomplete information, and studies from which data extraction was impossible.
Cite this research | Vol.: 100 | Issue: 11 | No. of pages: 9 | Language: English | Topics: Health | Tags: adolescent health, child health, COVID-19, diseases
Screening of COVID-19 in outpatient children with cancer or solid organ transplantation: preliminary report

AUTHOR(S)
Thaís Lira Cleto-Yamane; Gustavo Rodrigues-Santos; Maria Clara de Magalhães-Barbosa

Published: March 2021   Journal: European Journal of Pediatrics
Clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric immunosuppressed patients is unknown. Emerging data describe a milder or asymptomatic course in children compared with adults in this scenario. This paper presents the seroprevalence and clinical features of coronavirus disease 2019 in a prospective cohort of 114 immunosuppressed children and adolescents from three groups: kidney transplantation, liver transplantation, and cancer patients.
COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study

AUTHOR(S)
Meera Shaunak; Ravin Patel; Corine Driessens (et al.)

Published: March 2021   Journal: BMJ Open
This prospective observational cohort study aims to describe the frequency of symptoms compatible with SARS-CoV-2 infection in immunocompromised children and young people in the UK during the SARS-CoV-2 pandemic. To describe patient/ parent anxiety regarding SARS-CoV-2 infection in this cohort.
Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

AUTHOR(S)
Harriet Forbes; Caroline E. Morton; Seb Bacon (et al.)

Published: March 2021
This  population based cohort study, on behalf of NHS England, aimed to investigate whether risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outcomes of coronavirus disease 2019 (covid-19) differed between adults living with and without children during the first two waves of the UK pandemic.
Children during the COVID-19 pandemic: children and young people’s vulnerability and wellbeing in Indonesia

AUTHOR(S)
Santi Kusumaningrum; Clara Siagian; Harriot Beazley

Published: March 2021   Journal: Children's Geographies
This Viewpoint discusses the impact of the COVID-19 pandemic, and the Indonesian government’s response, on children and young people. By adopting a geographical and socio-spatial analysis the paper discusses the extent to which the response to the crisis has aggravated the detrimental impacts of the emergency on children. We argue that the government’s decision to transition to the ‘new normal’ was premature, endangering marginalized children who have less power, weaker voices, and a lack of access to the necessary resources to protect themselves. The paper focuses on children’s vulnerability and inequality during the crisis, and demands careful consideration for the governance of emergency response and recovery policies in the future.
Evaluation of the effect of the COVID‐19 pandemic on sleep disorders and nutrition in children

AUTHOR(S)
İzzet Fidancı; Hilal Aksoy; Duygu Yengil Taci (et al.)

Published: March 2021   Journal: The International Journal of Clinical Practice

The aim of the study was to evaluate the possible changes in sleep behavior and nutrition in children during the pandemic period. One hundred fourteen parents who accepted to participate in the study aged 18 and over and who had children between the ages of 6 and 16 were included in the study. A questionnaire was carried out after written consents were obtained. In the first part of the questionnaire, there were a total of 9 questions including socio‐demographic information and nutritional characteristics, and the second part included the “Sleep Disturbance Scale for Children” (SDSC). The data were analyzed with the SPSS 20 statistical program.

High rates of antibiotic prescriptions in children with COVID‐19 or multisystem inflammatory syndrome: a multinational experience in 990 cases from Latin America

AUTHOR(S)
Adriana Yock- Corrales; Jacopo Lenzi; Rolando Ulloa- Gutiérrez (et al.)

Published: March 2021   Journal: Acta Paediatrica

This study aims to assess rates of antibiotic prescriptions and its determinants in in children with COVID‐19 or Multisystem Inflammatory Syndrome (MIS‐C). Children <18 years‐old assessed in five Latin Americas countries with a diagnosis of COVID‐19 or MIS‐C were enrolled. Antibiotic prescriptions and factors associated with their use were assessed.


Cite this research | Open access | No. of pages: 9 | Language: English | Topics: Health | Tags: child health, COVID-19, multi-country, pharmaceuticals
Implications of the school-household network structure on SARS-CoV-2 transmission under school reopening strategies in England

AUTHOR(S)
James D. Munday; Katharine Sherratt; Sophie Meakin (et al.)

Published: March 2021   Journal: Nature Communications
In early 2020 many countries closed schools to mitigate the spread of SARS-CoV-2. Since then, governments have sought to relax the closures, engendering a need to understand associated risks. Using address records, this study construct a network of schools in England connected through pupils who share households. It evaluates the risk of transmission between schools under different reopening scenarios. It shows that whilst reopening select year-groups causes low risk of large-scale transmission, reopening secondary schools could result in outbreaks affecting up to 2.5 million households if unmitigated, highlighting the importance of careful monitoring and within-school infection control to avoid further school closures or other restrictions.
Model-based projections for COVID-19 outbreak size and student-days lost to closure in Ontario childcare centres and primary schools

AUTHOR(S)
Brendon Phillips; Dillon T. Browne; Madhur Anand (et al.)

Published: March 2021   Journal: Scientific Reports volume
There is a pressing need for evidence-based scrutiny of plans to re-open childcare centres during the COVID-19 pandemic. This study developed an agent-based model of SARS-CoV-2 transmission within a childcare centre and households. Scenarios varied the student-to-educator ratio (15:2, 8:2, 7:3), family clustering (siblings together versus random assignment) and time spent in class.
Risk profiles of severe illness in children with COVID-19: a meta-analysis of individual patients

AUTHOR(S)
Bo Zhou; Yuan Yuan; Shunan Wang (et al.)

Published: March 2021   Journal: Pediatric Research
We prepared a meta-analysis on case reports in children with COVID-19, aiming to identify potential risk factors for severe illness and to develop a prediction model for risk assessment. Literature retrieval, case report selection, and data extraction were independently completed by two authors. STATA software (version 14.1) and R programming environment (v4.0.2) were used for data handling.
Cite this research | Open access | No. of pages: 6 | Language: English | Topics: Health | Tags: at risk children, child health, COVID-19
16 - 30 of 352

UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.

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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.