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Children and COVID-19 Research Library

UNDER DEVELOPMENT UNICEF Innocenti's curated library of COVID-19 + Children research

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31 - 45 of 54
The urgent need for research coordination to advance knowledge on COVID-19 in children

Florence T. Bourgeois; Paul Avillach; Mark A. Turner

Published: November 2020   Journal: Pediatric Research
The emergence of coronavirus disease 2019 (COVID-19) prompted a surge in research activity. Funding bodies swiftly allocated resources to establish research infrastructures and partnerships to study the novel virus. The scientific community realigned existing research and launched new studies to define the clinical course of COVID-19 and identify therapeutic candidates. Overall, comparatively fewer studies were initiated in children relative to adults, in part due to the lower prevalence and disease morbidity recorded in pediatric populations. However, characterizing the disease in pediatric patients is critical to elucidate transmission dynamics, inform public health measures, and generate evidence on best practices for clinical care and therapeutic interventions. The life-threatening multisystem inflammatory syndrome further underscores the need for natural history studies and drug development in pediatric populations.
The challenges of a children’s hospital during the COVID-19 pandemic: the pediatric surgeon’s point of view

Gloria Pelizzo; Sara Costanzo; Luciano Maestri (et al.)

Published: November 2020   Journal: Pediatric Reports
During the coronavirus disease of 2019 (COVID-19) emergency, in the pediatric surgical setting, it has been essential to avoid and contain infections as well as to protect both the patients and the surgical team. During this emergency, procedures and workflow were adapted to provide the safest possible environment for both the surgical team and the patients. Pediatric surgical activities were reorganized during the COVID-19 pandemic at the “Vittore Buzzi” Children’s Hospital, which is a pediatric/maternal hospital located in Milan (Lombardy Region), Italy. Resources were optimized in order to maintain high levels of care and quality of assistance. During the COVID-19 emergency, the pediatric surgical department at the “Vittore Buzzi” Children’s Hospital became an acute care surgical service.
Who should be prioritized for COVID-19 vaccination?

Fiona M. Russell; Brian Greenwood

Published: November 2020   Journal: Human Vaccines & Immunotherapeutics
The development of COVID-19 vaccines is occurring at a rapid pace, with the potential for a vaccine to be available within 6 months. So who should be prioritized for vaccination when in the first instance, there will be insufficient supply to meet demand? There is no doubt that health-care workers in all settings should be vaccinated first, but who comes next will be a complex decision based on local epidemiology, societal values, and the ability of the vaccines to prevent both severe disease and to reduce transmission thereby eliciting herd protection. The decision on who to vaccinate should be equitable, highly contextualized, and based on the property of each vaccine. In some settings, the elderly may be prioritized, in others, it may be the population most likely to get infected and responsible for community spread. To support decision-making on who to be prioritized for vaccination requires urgent additional research on the epidemiology of COVID-19; preexisting immunity and who is responsible for transmission in a variety of settings; the safety, immunogenicity, and efficacy of COVID-19 vaccines in children and pregnant women; and determining whether COVID-19 vaccines prevent asymptomatic infection and transmission.
Caregiver willingness to vaccinate their children against COVID-19: Cross sectional survey

Ran D. Goldman; Tyler D. Yan; Michelle Seiler (et al.)

Published: November 2020   Journal: Vaccine
More than 100 COVID-19 vaccine candidates are in development since the SARS-CoV-2genetic sequence was published in January 2020. The uptake of a COVID-19 vaccine among children will be instrumental in limiting the spread of the disease as herd immunity may require vaccine coverage of up to 80% of the population. Prior history of pandemic vaccine coverage was as low as 40% among children in the United States during the 2009 H1N1 influenza pandemic. This paper aims to investigate predictors associated with global caregivers’ intent to vaccinate their children against COVID-19, when the vaccine becomes available.
Cite this research | Open access | Vol.: 38 | Issue: 48 | No. of pages: 7668-7673 | Language: English | Topics: Health | Tags: COVID-19 response, disease control, disease transmission, vaccination | Countries: United States
The management of children with cancer during the COVID-19 pandemic: a rapid review

Matteo Amicucci; Angela Mastronuzzi; Italo Ciaralli (et al.)

Published: October 2020   Journal: Journal of Clinical Medicine
Despite the fact that cancer patients seem to be at a higher risk of being infected with SARS-CoV-2, limited data are available in the pediatric oncology setting. A systematic rapid review was conducted to analyze scientific literature regarding the management, interventions, and strategies adopted to prevent the spread of COVID-19 in the pediatric cancer population. Our search on PubMed, Scopus, Cochrane, and EMBASE databases yielded 505 articles.
Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children

Judith R. Glynn; Paul A. H. Moss

Published: October 2020   Journal: Scientific Data

The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis, this study identifies 142 datasets with information on severity of disease by age for 32 different infectious diseases, 19 viral and 13 bacterial. For almost all infections, school-age children have the least severe disease, and severity starts to rise long before old age. Indeed, for many infections even young adults have more severe disease than children, and dengue was the only infection that was most severe in school-age children. Together with data on vaccine response in children and young adults, the findings suggest peak immune function is reached around 5–14 years of age. Relative immune senescence may begin much earlier than assumed, before accelerating in older age groups. This has major implications for understanding resilience to infection, optimal vaccine scheduling, and appropriate health protection policies across the life course.

The right to education and ICT during COVID-19: an international perspective

Luis Miguel Lázaro Lorente; Ana Ancheta Arrabal; Cristina Pulido-Montes

Published: October 2020   Journal: Sustainability
There is a lack of concluding evidence among epidemiologists and public health specialists about how school closures reduce the spread of COVID-19. Herein, we attend to the generalization of this action throughout the world, specifically in its quest to reduce mortality and avoid infections. Considering the impact on the right to education from a global perspective, this article discusses how COVID-19 has exacerbated inequalities and pre-existing problems in education systems around the world. Therefore, the institutional responses to guaranteeing remote continuity of the teaching–learning process during this educational crisis was compared regionally through international databases.
Age-structured model for COVID-19: Effectiveness of social distancing and contact reduction in Kenya

Mark Kimathi; Samuel Mwalili; Viona Ojiambo (et al.)

Published: October 2020   Journal: Infectious Disease Modelling
Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2. Kenya reported its first case on March 13, 2020 and by March 16, 2020 she instituted physical distancing strategies to reduce transmission and flatten the epidemic curve. An age-structured compartmental model was developed to assess the impact of the strategies on COVID-19 severity and burden. Contacts between different ages are incorporated via contact matrices. Simulation results show that 45% reduction in contacts for 60-days period resulted to 11.5–13% reduction of infections severity and deaths, while for the 190-days period yielded 18.8–22.7% reduction. The peak of infections in the 60-days mitigation was higher and happened about 2 months after the relaxation of mitigation as compared to that of the 190-days mitigation, which happened a month after mitigations were relaxed. Low numbers of cases in children under 15 years was attributed to high number of asymptomatic cases. High numbers of cases are reported in the 15–29 years and 30–59 years age bands. Two mitigation periods, considered in the study, resulted to reductions in severe and critical cases, attack rates, hospital and ICU bed demands, as well as deaths, with the 190-days period giving higher reductions.
Risk factors for re‐detectable positivity in recovered COVID‐19 children

Denggao Peng; Jing Zhang; Yiling Ji (et al.)

Published: October 2020   Journal: Pediatric Pulmonology

This paper aims to identify the risk factors for redetectable positivity, and to provide a basis for prevention and control of coronavirus disease‐2019 (COVID‐19) in children. A retrospective study was performed on all pediatric patients diagnosed with COVID‐19. Redetectable positivity was defined as the positive result of real‐time reverse transcriptase polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) after symptom resolution and discharge. Children were defined as being less than 18 years old.

Cite this research | Open access | Vol.: 55 | Issue: 12 | No. of pages: 3602-3609 | Language: English | Topics: Health | Tags: child health, COVID-19, disease control, disease prevention
What chances do children have against COVID-19? Is the answer hidden within the thymus?

Hatice Güneş; Serpil Dinçer; Can Acıpayam (et al.)

Published: October 2020   Journal: European Journal of Pediatrics
As with other types of coronaviruses, SARS-CoV-2 affects children less frequently, and it has been observed that the disease is mild. In the pathogenesis of a standard viral infection, the pathogen’s contact with the mucosa is initially followed by an innate immunity response. T cells are the primary decisive element in adaptive immunity capability. For this reason, the adaptive immune response mediated by the thymus is a process that regulates the immune response responsible for preventing invasive damage from a virus. Regulatory T cells (T-reg) are active during the early periods of life and have precise roles in immunomodulation. The thymus is highly active in the intrauterine and neonatal period; it begins to shrink after birth and continues its activity until adolescence. The loss of T-reg function by age results in difficulty with the control of the immune response, increased inflammation as shown in coronavirus disease (COVID-19) as an inflammatory storm. Also, the thymus is typically able to replace the T cells destroyed by apoptosis caused by the virus. Thymus and T cells are the key factors of pathogenesis of SARS-CoV-2 in children. Since thymus activity and T lymphocyte function in children protect them against the virus effects, stimulating and preventing the inhibition of the thymus can be possible treatment components against COVID-19.
COVID-19 trends among school-aged children — United States, March 1–September 19, 2020

Rebecca T. Leeb; Sandy Price; Sarah Sliwa (et al.)

Published: October 2020   Journal: Morbidity and Mortality Weekly Report

Children aged <10 years can transmit SARS-CoV-2 in school settings, but less is known about COVID-19 incidence, characteristics, and health outcomes among school-aged children (aged 5–17 years) with COVID-19. Since March, 277,285 COVID-19 cases in children have been reported. COVID-19 incidence among adolescents aged 12–17 years was approximately twice that in children aged 5–11 years. Underlying conditions were more common among school-aged children with severe outcomes related to COVID-19. Weekly incidence, SARS-CoV-2 test volume, and percentage of tests positive among school-aged children varied over time and by region of the United States. It is important for schools and communities to monitor multiple indicators of COVID-19 among school-aged children and layer prevention strategies to reduce COVID-19 disease risk for students, teachers, school staff, and families. These results can provide a baseline for monitoring trends and evaluating mitigation strategies.

Cite this research | Vol.: 69 | No. of pages: 1410-1415 | Language: English | Topics: Health | Tags: child health, COVID-19, disease control, disease transmission, schools | Countries: United States
Adapting HIV services for pregnant and breastfeeding women, infants, children, adolescents and families in resource‐constrained settings during the COVID‐19 pandemic

Alexandra C. Vrazo; Rachel Golin; Nimasha B. Fernando (et al.)

Published: September 2020   Journal: Journal of the International AIDS Society
Protecting pregnant and breastfeeding women, infants, children and adolescents from acquiring SARS‐CoV‐2 while sustaining essential HIV services is an immense global health challenge. Tailored, family friendly programme adaptations for case‐finding, ART delivery and viral load monitoring for these populations have the potential to limit SARS‐CoV‐2 transmission while ensuring the continuity of life‐saving HIV case identification and treatment efforts.
Responding to non-communicable diseases during and beyond the COVID-19 pandemic

This brief provides guidance for governments, policymakers, UN agencies and development partners to address non-communicable diseases (NCDs) as an integral part of the COVID-19 response and in broader efforts for achieving the 2030 Agenda for Sustainable Development. NCDs, such as cardiovascular disease, cancer, diabetes and chronic respiratory disease, are amplifying the impacts of COVID-19, and COVID-19 is exacerbating the burden of NCDs, particularly in already disadvantaged communities. Almost one fourth (22%) of the global population is estimated to have an underlying condition that increases their vulnerability to COVID-19, and most of these conditions are NCDs. Urgent action across sectors is needed to address the root causes of NCDs and increase access to affordable and quality treatments and prevention.

A citizen science facemask experiment and educational modules to improve coronavirus safety in communities and schools

Sarah E. Eichler; Austin P. Hopperton; Juan José Alava (et al.)

Published: September 2020   Journal: Frontiers in Medicine
There is need to support facemask citizen science and experiential education among children and families as the globe exits from the current lockdown, and teachers and students desire and seek for safe strategies to return to densely-attended schools. COVID-19 is a pandemic respiratory disease that disseminates as infectious respiratory or saliva droplets are released into the environment as people talk, sneeze, and cough. Currently the most publicized methods to prevent local transmission of COVID-19 and promote “droplet safety” in hospitals and communities include hand washing, social distancing, and stay-at-home strategies. In contrast to established benefits for medical masks in hospitals, the benefits of wearing masks or face covers/coverings (hereafter, “facemask”) in the community have been inconsistently debated by the media, creating confusion, and misinformation. Furthermore, high-profile political leaders in countries heavily affected by the pandemic have given misleading signs regarding containment measures associated with COVID-19 increasingly polarizing local communities around arguments on the value of facemasks in promoting public health, which is critically important to incentivize during the emergence of citizens from their lockdowns and during the phase of reopening local economies.
An analysis of child-care and school outbreak data and evidence-based recommendations for opening schools & keeping them open

Fiona Russell; Kathryn Snow; Margie Danchin (et al.)

Published: September 2020
This report is an analysis of the global literature and available Early Childhood Education and Care (ECEC) and school outbreak data, 25 January 2020 – 31 August 2020. It aims to explore the role of ECEC and schools in transmission of SARS-CoV-2.
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UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.