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Children and COVID-19 Research Library

UNICEF Innocenti's curated library of COVID-19 + Children research

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31 - 45 of 236
COVID-19 and cause of pregnancy loss during the pandemic: a systematic review

Seyyedeh Neda Kazemi; Bahareh Hajikhani; Hamidreza Didar (et al.)

Published: August 2021   Journal: Plos One

The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19 pandemic. This systematic review aimed to understand better the potential effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on fetal loss in infected mothers presented with abortion following this infection. It included articles published in PubMed/Medline, Web of Science,, and Embase databases in 2019 and 2020 through a comprehensive search via appropriate keywords, including COVID-19 and abortion synonyms. All studies with the abortion data in COVID-19 confirmed pregnant females were collected.

COVID-19 vaccination during pregnancy: coverage and safety

Helena Blakeway; Smriti Prasa; Erkan Kalafat (et al.)

Published: August 2021   Journal: American Journal of Obstetrics and Gynecology

Concerns have been raised regarding a potential surge of COVID-19 in pregnancy, secondary to rising numbers of COVID-19 in the community, easing of societal restrictions, and vaccine hesitancy. Even though COVID-19 vaccination is now offered to all pregnant women in the UK, there are limited data on its uptake and safety. This was a cohort study of pregnant women who gave birth at St George’s University Hospitals NHS Foundation Trust, London, UK, between March 1st and July 4th 2021. The primary outcome was uptake of COVID-19 vaccination and its determinants. The secondary outcomes were perinatal safety outcomes.

Safety of components and platforms of COVID-19 vaccines considered for use in pregnancy: a rapid review

Agustín Ciapponi; Ariel Bardach; Agustina Mazzoni (et al.)

Published: August 2021

Rapid assessment of COVID-19 vaccine safety during pregnancy is urgently needed. This study conducted a rapid systematic review, to evaluate the safety of COVID-19 vaccines selected by the COVID-19 Vaccines Global Access-Maternal Immunization Working Group in August 2020, including their components and their technological platforms used in other vaccines for pregnant persons. It searched literature databases, COVID-19 vaccine pregnancy registries, and explored reference lists from the inception date to February 2021 without language restriction. Pairs of reviewers independently selected studies through COVIDENCE, and performed the data extraction and the risk of bias assessment. Discrepancies were resolved by consensus.

Characteristics and outcomes of women with COVID-19 giving birth at US academic centers during the COVID-19 pandemic
Published: August 2021   Journal: JAMA Network Open

What are the characteristics and outcomes associated with giving birth with COVID-19 over the first year of the pandemic in the US? This cohort study examines 869 079 adult women, including 18 715 women with COVID-19, who underwent childbirth at 499 US medical centers between March 1, 2020, and February 28, 2021. Women with COVID-19 had increased mortality, need for intubation and ventilation, and intensive care unit admission. These findings suggest that COVID-19 was associated with increased risk of morbidity and mortality for women giving birth.

Are COVID-19 mitigation measures reducing preterm birth rate in China?
Published: August 2021   Journal: BMJ Global Health

Preterm birth is the leading cause of child morbidity and mortality globally. We aimed to determine the impact of the COVID-19 mitigation measures implemented in China on 23 January 2020 on the incidence of preterm birth in our institution. Logistic regression analysis was used to investigate the association between the national COVID-19 mitigation measures implemented in China and the incidence of preterm birth.

Lived experiences of the partners of COVID-19 positive childbearing women: a qualitative study

Antonella Nespoli; Sara Ornaghi; Sara Borrelli (et al.)

Published: August 2021   Journal: Women and Birth

Several maternity units worldwide have rapidly put in place changes to maternity care pathways and restrictive preventive measures in the attempt to limit the spread of COVID-19, resulting in birth companions often not being allowed to be present at birth and throughout hospital admission. The WHO strongly recommends that the emotional, practical, advocacy and health benefits of having a chosen birth companion are respected and accommodated, including women with suspected, likely or confirmed COVID-19. This study aims to explore the lived experiences of the partners of COVID-19 positive childbearing women who gave birth during the first pandemic wave (March and April 2020) in a Northern Italy maternity hospital.

Knowledge, attitude and practice toward Corona virus infection among pregnant women attending antenatal care at public hospitals in three Wollega zones, Ethiopia

Merga Besho; Reta Tsegaye; Mekdes Tigistu Yilma (et al.)

Published: July 2021   Journal: International Journal of General Medicine
Pregnancy is an immune-suppressed state which makes pregnant women generally more susceptible to COVID-19 infection and severe illness. Extensive precautions have been recommended to avoid exposure to the virus. Knowledge and attitude toward the disease play an integral role in readiness to accept public health measures. This study aimed to assess the knowledge, attitude and practice towards COVID-19 among pregnant women attending antenatal clinics in three Wollega zones, Ethiopia. Institution-based cross-sectional study was employed among 415 pregnant women attending antenatal care at public hospitals in three Wollega zones, Ethiopia from July to August 2020.
Elevated risk for obsessive–compulsive symptoms in women pregnant during the COVID-19 pandemic

Brittain L. Mahaffey; Amanda Levinson; Heidi Preis (et al.)

Published: July 2021   Journal: Archives of Women's Mental Health
The COVID-19 pandemic has led to a public mental health crisis with many people experiencing new or worsening anxiety. Fear of contagion and the lack of predictability/control in daily life increased the risk for problems such as obsessive–compulsive disorder (OCD) in the general population. Pregnant women may be particularly vulnerable to such pandemic-related stressors yet the prevalence of OC symptoms in this population during the pandemic remains unknown. This study examined the prevalence of OC symptoms in a sample of 4451 pregnant women in the USA, recruited via targeted online methods at the start of the pandemic. Participants completed self-report measures including the Obsessive–Compulsive Inventory-Revised and the Pandemic-Related Pregnancy Stress Scale. Clinically significant OC symptoms were present in 7.12% of participants, more than twice as high as rates of peripartum OCD reported prior to the pandemic.
The relationship between common mental disorders (CMDs), food insecurity and domestic violence in pregnant women during the COVID-19 lockdown in Cape Town, South Africa

Zulfa Abrahams; Sonet Boisits; Marguerite Schneider (et al.)

Published: July 2021   Journal: Social Psychiatry and Psychiatric Epidemiology

This study aimed to explore the relationship between common mental disorders (CMDs), food insecurity and experiences of domestic violence among pregnant women attending public sector midwife obstetric units and basic antenatal care clinics in Cape Town during the COVID-19 lockdown. Perinatal women, attending 14 healthcare facilities in Cape Town, were enrolled in the study during baseline data collection before the COVID-19 lockdown. During the lockdown period, fieldworkers telephonically contacted the perinatal women who were enrolled in the study and had provided contact details. The following data were collected from those who consented to the study: socio-demographic information, mental health assessment, food insecurity status and experiences of domestic violence. Poisson regression was used to model the associations of a number of risk factors with the occurrence of CMDs.

COVID-19 in Ghana: challenges and countermeasures for maternal health service delivery in public health facilities

Faith Agbozo; Albrecht Jahn

Published: July 2021   Journal: Reproductive Health
This study provides a situational update on COVID-19 in Ghana, the seventh African country reporting the most cases. Some modifications occurring within the health system to curtail the outbreak and its potential impact on the delivery of antenatal care services are also highlighted. With the discovery of the Delta variant in Ghana, the current attention is to prevent a third wave of infection, and also control and manage existing cases. Efforts to procure vaccines, vaccinate special populations and sensitize the public on the implications of vaccine hesitancy are ongoing.
COVID-19 deliveries: maternal features and neonatal outcomes

Viviana Zlochiver; Blair Tilkens; Ana Cristina Perez Moreno (et al.)

Published: July 2021   Journal: Journal of Patient-Centered Research and Reviews
Integrated, data-driven criteria are necessary to evaluate delivery outcomes in pregnancies affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the ongoing COVID-19 pandemic. This study analyzed maternal demographics, clinical characteristics, treatments, and delivery outcomes of 85 ethnically diverse, adult pregnant women who tested positive for SARS-CoV-2 at the time of delivery. Median maternal and gestational ages were 27 years (interquartile range [IQR]: 23–31) and 39 weeks (IQR: 37.3–40.0), respectively.
Impact of coronavirus 2019 on mental health and lifestyle adaptations of pregnant women in the United Arab Emirates: a cross-sectional study

Mona Hashim; Ayla Coussa; Ayesha S. Al Dhaher (et al.)

Published: July 2021   Journal: BMC Pregnancy and Childbirth

In light of the pandemic, pregnant women are particularly vulnerable to increased psychological distress and in need of imperative preventive measures. This study aimed to investigate the impact of the pandemic on mental health, lifestyle adaptations, and their determinants among pregnant women in the United Arab Emirates. A survey was conducted electronically between June and August 2020. Pregnant women were recruited from prenatal clinics in the UAE and invited to participate in an online survey developed on Google Forms. The questionnaire included socio-demographic characteristics, the Impact of Event Scale- Revised, the Perceived Support Scale and lifestyle-related factors.

Challenges and opportunities during the COVID-19 pandemic: treating patients for substance use disorders during the perinatal period

Hendrée E. Jones; Essence Hairston; Ashley C. Lensch (et al.)

Published: July 2021   Journal: Preventive Medicine
The United States of America faces an opioid use disorder epidemic and growing rates of alcohol and other substance use disorders within the coronavirus disease 2019 (COVID-19) pandemic. Pregnant and post-pregnant individuals are also adversely affected by the substance use disoder epidemic in a pandemic. Physical safety measures preventing COVID-19 also trigger initiation, resumption or intensification of alcohol and other substance use among some individuals, including pregnant and post-pregnant people. Collectively, increasing alcohol use and the opioid epidemic interwoven within the COVID-19 pandemic warrant attention among all people, including pregnant and post-pregnant people. Sudden service delivery transitions during the COVID-19 pandemic not only reduced access to opioid use disorder treatment care but also created engagement issues.
Reproductive health crisis during waves one and two of the COVID-19 pandemic in India: Incidence and deaths from severe maternal complications in more than 202,000 hospital births

Manisha Nair

Published: July 2021   Journal: EClinicalMedicine
The SARS-CoV-2 pandemic in India has adversely affected many aspects of population health. We need detailed evidence of the impact on reproductive health in India so that lessons can be learnt. Hospital-based repeated monthly survey of nine severe maternal complications and death in 15 hospitals across five states in India covering a total of 202,986 hospital births, December-2018 through to May-2021. We calculated incidence rates (with 95% confidence intervals (CIs)) per 1000 hospital births, case-fatality and rate ratios (RR) with 95% CIs. Linear regression was used to examine the association between the Government Response Stringency Index (GRSI) for India and changes in hospital births, incidence and case-fatality.
The association of COVID-19 infection in pregnancy with preterm birth: a retrospective cohort study in California

Deborah Karasek; Rebecca J. Baer; Monica R. McLemore (et al.)

Published: July 2021   Journal: The Lancet Regional Health - Americas
There is a limited understanding of the association between coronavirus disease 19 (COVID-19) and preterm or early term birth among racially and ethnically diverse populations and people with chronic medical conditions. This study determined the association between COVID-19 and preterm (PTB) birth among live births documented by California Vital Statistics birth certificates between July 2020 and January 2021 (n=240,147). It used best obstetric estimate of gestational age to classify births as very preterm (VPTB, <32 weeks), PTB (< 37 weeks), early term (37 and 38 weeks), and term (39-44 weeks), as each confer independent risks to infant health and development. Separately, it calculated the joint effects of COVID-19 diagnosis, hypertension, diabetes, and obesity on PTB and VPTB.
31 - 45 of 236

UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.


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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.