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Children and COVID-19 Research Library

UNDER DEVELOPMENT UNICEF Innocenti's curated library of COVID-19 + Children research

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Coronavirus disease (COVID) 2019 in children: a short review

AUTHOR(S)
Sham Balkisanji Lohiya; Sachin Damke; Richa Chaudhary

Published: September 2020   Journal: International Journal of Current Research and Review
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a series of Cases of severe pneumonia worldwide. It originated in Wuhan in Hubei province, China. SARS-CoV-2 causes infection by ACE receptors, similar to SARS. It causes potential damage to vital organs, mainly the lungs. COVID- 19 mainly affects respiratory tract with symptoms ranging from upper respiratory tract infection like symptoms to full-blown ARDS. Although the pediatric age group is shown to be less susceptible to severe infection, they can very well act as an intermediate in the transmitter of the virus. Treatment is symp-tomatic for mild diseases, but severe disease and ARDS require ICU management and specific treatment.
Cite this research | Open access | Vol.: 12 | Issue: 17 | No. of pages: 172-177 | Language: English | Topics: Health | Tags: child health, medical care, respiratory diseases
Decrease of respiratory diseases in one social children welfare institute in Shanxi Province during COVID-19

AUTHOR(S)
B. Liu; Q. F. Han; W. P. Liang

Published: September 2020   Journal: Journal of Public Health
This study surveyed and analyzed common diseases among children under the age of 14 in one social children welfare institute in Shanxi Province from January to May in 2018–2020 by the year-on-year method. In view of the above anti-epidemic measures, it indicates that the children gathering institutions should strengthen effective personal protection and public health management to reduce infectious disease among children.
Cite this research | Open access | No. of pages: 5 | Language: English | Topics: Health | Tags: child diseases, institutionalized children, respiratory diseases | Countries: China
Sars-cov-2 infection in children in Southern Italy: a descriptive case series

AUTHOR(S)
Daniela Loconsole; Desirèe Caselli; Francesca Centrone (et al.)

Published: August 2020   Journal: International Journal of Environmental Research and Public Health
This study analyzed the frequency of SARS-CoV-2 infection among all children aged <18 years in the Apulia region of Southern Italy and the characteristics of the infected children. Clinical and demographic data were collected through the national platform for COVID-19 surveillance.
Cite this research | Open access | Vol.: 17 | Issue: 17 | Language: English | Topics: Health | Tags: child health, respiratory diseases, COVID-19 | Countries: Italy
COVID-19 in children: should we be worried?

AUTHOR(S)
Candice Laverne Hendricks

Published: August 2020   Journal: South African Medical Journal
Reports indicate that children infected with SARS-CoV-2 have thus far presented with less severe disease than adults. Anxiety regarding a greater ability to transmit the virus is largely unfounded and has played a significant role in the decision to allow children to return to school. In some patients, however, especially in infants and in those with underlying comorbidities, severe disease must be anticipated and planned for accordingly. The most relevant severe clinical presentation in addition to the established respiratory complications, is that of a multisystem inflammatory disorder, with features resembling Kawasaki disease.
Overview of management of children with COVID-19

AUTHOR(S)
Dyah Kanya Wati; Arya Krisna Manggala

Published: July 2020   Journal: Clinical and Experimental Pediatrics
The widespread and contagious coronavirus disease 2019 (COVID-19) has become a burden in the global health domain. The subsequent discovery of the virus features and pathogenesis, and prompt and adequate management are still lacking and remain inconclusive. Children usually present milder symptoms than adults, and management focuses on providing symptomatic and respiratory supports. Several treatment modalities, including the utilization of mechanical ventilation (MV), antivirals, immune-modulating drugs, or other agents, may present promising results in reducing the symptoms of COVID-19, particularly in severe cases. Although no randomized clinical trials have been published to date, it is interesting to explore potential modalities for treating COVID-19 in children, based on review articles, case reports, and recent guidelines.
Cite this research | Open access | Vol.: 63 | Issue: 9 | No. of pages: 345-354 | Language: English | Topics: Health | Tags: child care, child health, respiratory diseases, COVID-19
COVID-19 in Children: An Ample Review

AUTHOR(S)
Ioana M Ciuca

Published: June 2020   Journal: Risk management and healthcare policy
The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. An extensive literature search was performed to identify papers on COVID-19 (SARS-CoV-2 infection) in children, published between January 1, 2020 and April 1, 2020. There were 44 relevant papers on COVID-19 in children. The results showed that COVID-19 occurs in 0.39–12.3% of children. Clinical signs and symptoms are comparable to those in adults, but milder forms and a large percentage of asymptomatic carriers are found among children. Elevated inflammatory markers are associated with complications and linked to various co-infections. Chest computed tomography (CT) scans in children revealed structural changes similar to those found in adults, with consolidations surrounded by halos being somewhat specific for children with COVID-19. The recommended treatment includes providing symptomatic therapy, with no specific drug recommendations for children. The prognosis is much better for children compared to adults. This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. The prognosis is much better for children compared to adults, but with the progression of the pandemic; the cases in children might change in the future.
COVID-19 in Children and Adolescents in Europe: A Multinational, Multicentre Cohort Study

AUTHOR(S)
Petra Prunk; Veronika Osterman; Uros Krivec (et al.)

Institution: The Lancet
Published: June 2020   Journal: The Lancet Child & Adolescent Health
To date, few data on paediatric COVID-19 have been published, and most reports originate from China. This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.
Coronavirus disease 2019 (COVID-19) in children and/or adolescents: a meta-analysis

AUTHOR(S)
Alessandro Mantovani; Elisabetta Rinaldi; Chiara Zusi (et al.)

Published: June 2020   Journal: Nature Paediatric Research
This review systematically researched in PubMed, Scopus and Web of Science databases observational studies describing COVID-19 in children and/or adolescents until April 11, 2020. Data regarding clinical and radiological features were extracted from eligible studies and meta-analysis was performed using random-effects modeling. The study finds that children and/or adolescents tend to have a mild COVID-19 course with a good prognosis.
Compared to adults, children and/or adolescents tend to have a mild COVID-19 course with a good prognosis.
Pediatric COVID-19: Systematic review of the literature

AUTHOR(S)
Patel Neha

Published: May 2020   Journal: American Journal of Otolaryngology
A systematic review of the literature was performed to gain insight into pediatric COVID-19 epidemiology. Specifically, Pubmed and Google Scholar databases were searched to identify any relevant article with a focus on Pediatric Covid 19, Pediatric Covid-19, Pediatric SARS-COV-2, and Pediatric Coronavirus 19. Results show that, in contrast to adults, most infected children appear to have a milder course and have better outcomes overall. Additional care may be needed for children with comorbidities and younger children. This review also suggests that unilateral CT chest imaging findings were seen in 36.4% pediatric COVID-19 patients. This is particularly concerning as the work-up of pediatric patients with cough may warrant a bronchoscopy to evaluate for airway foreign bodies. Extra precautions need to be taken with personal protective equipment for these cases, as aerosolizing procedures may be a method of viral transmission.
Resistance of children to Covid-19. How?

AUTHOR(S)
Alain Fischer

Published: May 2020   Journal: Nature Mucosal Immunology
Both resistance to infection and resistance to disease appear to be much stronger in children than in adults. The apparent resistance to infection might actually reflect a more rapid clearance of the virus so that the chance to detect cases is diminished. Future studies on seropositivity prevalence should help to distinguish between these possibilities. Of note the increased male to female ratio as observed in adult Covid-19 patients (6 to 4) is also observed in children. Finally, children below the age of 1 year are over-represented in pediatric Covid-19 cohorts with a higher risk of fatality compared with children above the age of 1.
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COVID-19 & Children: Rapid Research Response

UNICEF Innocenti is mobilizing a rapid research response in line with UNICEF’s global response to the COVID-19 crisis. The initiatives we’ve begun will provide the broad range of evidence needed to inform our work to scale up rapid assessment, develop urgent mitigating strategies in programming and advocacy, and preparation of interventions to respond to the medium and longer-term consequences of the COVID-19 crisis. The research projects cover a rapid review of evidence, education analysis, and social and economic policies.