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AUTHOR(S) Giuseppe De Bernardo; Maurizio Giordano; Giada Zollo (et al.)
AUTHOR(S) Roberto Raschetti; Alexandre J. Vivanti ; Christelle Vauloup-Fellous (et al.)
AUTHOR(S) Judith R. Glynn; Paul A. H. Moss
The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis, this study identifies 142 datasets with information on severity of disease by age for 32 different infectious diseases, 19 viral and 13 bacterial. For almost all infections, school-age children have the least severe disease, and severity starts to rise long before old age. Indeed, for many infections even young adults have more severe disease than children, and dengue was the only infection that was most severe in school-age children. Together with data on vaccine response in children and young adults, the findings suggest peak immune function is reached around 5–14 years of age. Relative immune senescence may begin much earlier than assumed, before accelerating in older age groups. This has major implications for understanding resilience to infection, optimal vaccine scheduling, and appropriate health protection policies across the life course.
AUTHOR(S) Luis Miguel Lázaro Lorente; Ana Ancheta Arrabal; Cristina Pulido-Montes
AUTHOR(S) Mohammed Alsuhaibani; Aqeel Alaqeel
AUTHOR(S) Constantin Aurelian Ionescu; Liliana Paschia; Nicoleta Luminita Gudanescu Nicolau (et al.)
AUTHOR(S) Milla Salin; Anniina Kaittila; Mia Hakovirta (et al.)
AUTHOR(S) Maria Cusinato; Sara Iannattone; Andrea Spoto (et al.)
AUTHOR(S) Gilmar Zambrana Cruz; Gwyther Rees
AUTHOR(S) Pasi Sahlberg
AUTHOR(S) Nick Spencer; Rita Nathawad; Emmanuele Arpin (et al.)
Inequity in routine childhood vaccination coverage is well researched. Pandemics disrupt infrastructure and divert health resources from preventive care, including vaccination programmes, leading to increased vaccine preventable morbidity and mortality. COVID-19 control measures have resulted in coverage reductions. We conducted a rapid review of the impact of pandemics on existing inequities in routine vaccination coverage. PICO search framework: Population: children 0–18 years; Intervention/exposure: pandemic/epidemic; Comparison: inequality; Outcome: routine vaccination coverage. The review demonstrates a gap in the literature as none of the 29 papers selected for full-paper review from 1973 abstracts identified from searches met the inclusion criteria.
AUTHOR(S) Youngsoo Jang; Minchul Yum
AUTHOR(S) Estrella Romero; Laura López-Romero; Beatriz Domínguez-Álvarez (et al.)
AUTHOR(S) Natasha R. Magson; Justin Y. A. Freeman; Ronald M. Rapee (et al.)
AUTHOR(S) Peter Lachman
UNICEF Innocenti's Children and COVID-19 Library is a database collecting research from around the world on COVID-19 and its impacts on children and adolescents.
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COVID-19 & Children: Rapid Research Response