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Innocenti experts produce high quality research that is frequently published in international peer reviewed journals. The themes of publications featured here reflect the entire spectrum of issues shaping global policies and outcomes for children.
The evolving picture of SARS-CoV-2 and COVID-19 in children: critical knowledge gaps
The initial impression that paediatric infection is uncommon and generally mild has been replaced by a more nuanced understanding of infectious manifestations in children across countries and by income group, with recognition of a widening disease spectrum.
Critical knowledge gaps remain that have significant public policy and programme implications.
Insufficient age and race/ethnicity disaggregated data are hindering efforts to assess fully the prevalence of SARS-CoV-2 infection and COVID-19 in children and the role of children in transmission.
Potential biologic differences in susceptibility to infection and transmissibility between children and adults need to be explored.
Determination of mother-to-child SARS-CoV-2 transmission requires appropriate samples obtained with proper timing, lacking in most studies.
Predictors of disease progression and morbidity and mortality in children need to be determined, particularly as the pandemic moves to low-income and middle-income countries.
The full spectrum of SARS-CoV-2 infection in children remains to be defined, and surveillance for and investigation of the pathogenesis of postinfectious sequelae, such as multisystem inflammatory syndrome, are vital.